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Mucin 1/MUC1 抗体 (SM3): sc-53381

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说明书
  • Mucin 1/MUC1抗体(SM3)是小鼠单克隆IgG1 λ, 在11篇文献中引用,规格为200 µg/ml
  • 针对human来源的脱糖化牛奶粘蛋白
  • 抗-Mucin 1/MUC1 抗体 (SM3) 推荐用于 WB, IP, IF 和 IHC(P),检测mouse, rat 和human 来源的 Mucin 1
  • 抗Mucin 1/MUC1抗体(SM3)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgGλ BP-HRP(小鼠 IgGλ 结合蛋白-HRP)是Mucin 1/MUC1 Antibody (SM3) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。该试剂现可与Mucin 1/MUC1 Antibody (SM3) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGλ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。
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関連項目

Mucin 1 抗体(SM3)是一种小鼠单克隆 IgG1 抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和免疫组织化学等方法检测小鼠、大鼠和人类样本中的 Mucin 1。抗粘蛋白1抗体(SM3)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。粘蛋白1在细胞信号传导和粘附中起着至关重要的作用,它作为上皮表面的保护屏障,影响肿瘤的进展。粘蛋白1的表达在上皮肿瘤中尤为重要,例如乳腺癌,粘蛋白1可促进肿瘤的发生和转移。粘蛋白1主要定位于上皮细胞的顶端表面,在那里形成保护性的粘膜层,这对于维持组织的完整性和功能至关重要。了解Mucin 1的局部定位和功能对于开发癌症治疗中的靶向疗法至关重要,因为Mucin 1的过度表达可以作为恶性肿瘤的生物标志物。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Mucin 1/MUC1 抗体 (SM3) 参考文献:

  1. Tecemotide(L-BLP25)在多发性骨髓瘤患者中进行的粘蛋白1特异性主动癌症免疫疗法:探索性研究。  |  Rossmann, E., et al. 2014. Hum Vaccin Immunother. 10: 3394-408. PMID: 25483677
  2. 粘蛋白-1与肺腺癌的存活率、吸烟状况和生长模式相关。  |  Lappi-Blanco, E., et al. 2016. Tumour Biol. 37: 13811-13820. PMID: 27481516
  3. 尿液中的粘蛋白-1亚基α片段是一种与普通人群肾功能障碍相关的新型生物标记物  |  Zhang, ZY., et al. 2017. Kidney Int Rep. 2: 811-820. PMID: 28920100
  4. 大鼠过敏性气道炎症模型中粘蛋白1表达的变化。  |  Hasan, B., et al. 2018. Exp Lung Res. 44: 137-142. PMID: 29847197
  5. T细胞免疫球蛋白和黏蛋白1(Tim-1)的敲除通过抑制细胞因子-PI3K/AKT通路抑制胶质瘤的进展。  |  Zhou, P., et al. 2020. Onco Targets Ther. 13: 7433-7445. PMID: 32801766
  6. 结肠直肠癌中环氧合酶-2 和粘蛋白 1 的表达。  |  Szlendak, M., et al. 2020. Mol Clin Oncol. 13: 52. PMID: 32874582
  7. 基于hemin/graphene@PdPtNPs的新型粘蛋白1双信号和无标记电化学适配传感器。  |  Zhang, G., et al. 2021. Biosens Bioelectron. 173: 112785. PMID: 33189017
  8. 抑制缺氧诱导的粘蛋白1可改变人类成骨细胞产生的细胞外基质的蛋白质组组成,从而降低成骨和血管生成潜力。  |  Jadaun, PK., et al. 2022. J Cell Physiol. 237: 1440-1454. PMID: 34687046
  9. 膜拴系黏蛋白 1 在多种细胞类型中受干扰素和病毒感染的刺激,并抑制甲型流感病毒在人气道上皮细胞中的感染。  |  Iverson, E., et al. 2022. mBio. 13: e0105522. PMID: 35699372
  10. 基于具有固有自校准特性的Co-MOFs的超灵敏双信号电化学比率适配传感器,用于粘蛋白1。  |  Xie, FT., et al. 2022. Anal Chim Acta. 1225: 340219. PMID: 36038234

订购信息

产品名称产品编号规格价格数量收藏夹

Mucin 1/MUC1 抗体 (SM3)

sc-53381
200 µg/ml
CNY2422.00

Mucin 1/MUC1 (SM3): m-IgGλ BP-HRP 套装

sc-520974
200 µg Ab, 40 µg BP
CNY2715.00

Mucin 1/MUC1 抗体 (SM3) AC

sc-53381 AC
500 µg/ml, 25% agarose
CNY3189.00

Mucin 1/MUC1 抗体 (SM3) HRP

sc-53381 HRP
200 µg/ml
CNY2422.00

Mucin 1/MUC1 抗体 (SM3) FITC

sc-53381 FITC
200 µg/ml
CNY2527.00

Mucin 1/MUC1 抗体 (SM3) PE

sc-53381 PE
200 µg/ml
CNY2625.00

Mucin 1/MUC1 抗体 (SM3) Alexa Fluor® 488

sc-53381 AF488
200 µg/ml
CNY2738.00

Mucin 1/MUC1 抗体 (SM3) Alexa Fluor® 546

sc-53381 AF546
200 µg/ml
CNY2738.00

Mucin 1/MUC1 抗体 (SM3) Alexa Fluor® 594

sc-53381 AF594
200 µg/ml
CNY2738.00

Mucin 1/MUC1 抗体 (SM3) Alexa Fluor® 647

sc-53381 AF647
200 µg/ml
CNY2738.00

Mucin 1/MUC1 抗体 (SM3) Alexa Fluor® 680

sc-53381 AF680
200 µg/ml
CNY2738.00

Mucin 1/MUC1 抗体 (SM3) Alexa Fluor® 790

sc-53381 AF790
200 µg/ml
CNY2738.00

Do you know if sequence targeted by the antibodie is intra or extracellular?

Asked by: LilaGa
Thank you for your question. This mouse monoclonal antibody, Mucin 1 (SM3): sc-53381, is raised against hydrogen fluoride deglycosylated milk mucin of human origin. The exact epitope recognized by the antibody has not yet been determined, and therefore we do not know if the epitope is intracellular or extracellular.
Answered by: Technical Support
Date published: 2017-10-30

What is the molecular weight of Mucin 1 ?

Asked by: Trav11
Thank you for your question. Mucin 1 has an expected molecular weight of approximately 200 kDa. If you have any questions, please contact our Technical Service Department and we would be happy to assist you.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 1 out of 5 by CP75 from It doesn't work in mouse colon (Western Blot)Dilution tested 1:500 in mouse tissue estract. It doen't work.
Date published: 2020-10-07
Rated 4 out of 5 by alise from 特异性较好之前申请的试用装,结果显示,该抗体能特异性识别相应抗原,条带较清晰,适用于Western blot 检测。
Date published: 2018-04-24
Rated 5 out of 5 by lei b from 清晰的目标条带在胰腺癌细胞株中使用了这支抗体,有清晰的目的条带,未见杂带,背景清晰,使用浓度1:500,总体上是一支合适wb的抗体
Date published: 2018-04-02
Rated 5 out of 5 by Bashir M Mohamed from Vimentin (C-20)-R antibodyI was kindly given this antibody by Santa Cruz to try on my current project.
Date published: 2018-03-07
Rated 5 out of 5 by Kai Zhang from five starWorked well for Western Blotting in our validation of detection of Mucin 1 (mouse 1:500 dilution).
Date published: 2017-06-01
Rated 2 out of 5 by Bionaz from Not cross-reactivity with bovineWe have tried the antibody on cells isolated from bovine milk and we were unable to detect any binding; thus, we concluded that the antibody does not work on the extracellular region of bovine MUC1.
Date published: 2017-05-22
Rated 5 out of 5 by Trav11 from Great for WBThe Mucin 1 Antibody (SM3): sc-53381 provides clear band with minimal background in Western blot application.
Date published: 2017-01-19
Rated 5 out of 5 by QZ from Single strong band in DU 145 whole cell lysateSingle strong band in DU 145 whole cell lysate. -SCBT QC
Date published: 2015-02-03
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Mucin 1/MUC1 抗体 (SM3) is rated 4.1 out of 5 by 9.
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