Date published: 2025-9-7

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Mts1 抗体 (A-7): sc-377059

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说明书
  • Mts1 抗体 A-7 是小鼠单克隆 IgG2a κ,Mts1抗体, 在6篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列44-101位于human物种的Mts1的C-terminus
  • Mts1 抗体 (A-7) 推荐用于WB, IP, IF, IHC(P) 和 ELISA,检测human 来源的 Mts1; 也和以下物种反应,包括: porcine
  • 抗Mts1抗体(A-7)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Mts1 (A-7): sc-377059免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成Mts1 抗体 (A-7)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

Mts1抗体(A-7)是一种IgG2a κ小鼠单克隆Mts1抗体(也称为S10A4抗体、S100钙结合蛋白A4成纤维细胞特异性蛋白-1抗体、钙胎盘蛋白抗体、Calvasculin抗体、PEL98抗体、18A2抗体、CAPL抗体、FSP1抗体、MTS1抗体、P9KA抗体、42A抗体、白血病多药耐药相关蛋白抗体、恶性转化抑制1抗体、S100钙结合蛋白A4抗体或Metastasin抗体),可通过WB、IP、IF、IHC(P)和ELISA检测人类来源的Mts1蛋白。Mts1抗体(A-7)既可以是非偶联的抗Mts1抗体形式,也可以是多种偶联形式的抗Mts1抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Mts1基因编码一种小的酸性Ca2+结合蛋白Mts1(也称为S100A4、calvasculin或metastasin)。Mts1属于S100家族的小Ca2+结合蛋白,并以细胞特异性方式表达。Mts1蛋白参与肿瘤进展和转移,对血管生成也有显著的刺激作用。血清中Mts1蛋白水平随年龄增长而升高,提示Mts1可能通过刺激血管生成在肿瘤进展的诱导中发挥作用。此外,Mts1通过与p53的C端调节结构域结合,抑制p53的DNA结合活性,从而与p53合作诱导凋亡。Mts1增强p53依赖性凋亡的能力可能会加速肿瘤中p53功能的丧失。因此,Mts1可以在肿瘤进展过程中促进更具侵袭性的表型的发展。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Mts1 抗体 (A-7) 参考文献:

  1. 转移相关蛋白 S100A4(Mts1)的二聚化界面:体内和体外研究。  |  Tarabykina, S., et al. 2001. J Biol Chem. 276: 24212-22. PMID: 11278510
  2. 肿瘤抑制因子 p53 蛋白是转移相关 Mts1/S100A4 蛋白的新靶标:两者相互作用的功能性后果。  |  Grigorian, M., et al. 2001. J Biol Chem. 276: 22699-708. PMID: 11278647
  3. 转移相关的 Mts1(S100A4)蛋白可作为血管生成因子发挥作用。  |  Ambartsumian, N., et al. 2001. Oncogene. 20: 4685-95. PMID: 11498791
  4. 鉴定 Sp1, AP-1, CBF 和 KRC 结合位点以及作为转移相关 mts1/S100A4 基因内含子增强子功能元素的小卫星 DNA。  |  Cohn, MA., et al. 2001. Nucleic Acids Res. 29: 3335-46. PMID: 11504871
  5. mts1 基因的转录物分析,特别参考 5' 侧翼序列。  |  Tulchinsky, E., et al. 1992. Proc Natl Acad Sci U S A. 89: 9146-50. PMID: 1329089
  6. 相互依赖的血清素转运体和受体途径调控与肺血管疾病相关的基因 S100A4/Mts1。  |  Lawrie, A., et al. 2005. Circ Res. 97: 227-35. PMID: 16002749
  7. 患有肺动脉高压的 S100A4/Mts1 小鼠体内纤维蛋白-5 和弹性蛋白增加。  |  Merklinger, SL., et al. 2005. Circ Res. 97: 596-604. PMID: 16109920
  8. 原发性多形性胶质母细胞瘤中的 MTS1/p16/CDKN2 病变。  |  Moulton, T., et al. 1995. Am J Pathol. 146: 613-9. PMID: 7887443
  9. 钙粘蛋白是影响转染 src 基因的大鼠成纤维细胞微丝组装的一个因素。  |  Watanabe, Y., et al. 1993. FEBS Lett. 324: 51-5. PMID: 8504859
  10. EF 手钙结合蛋白 S100 家族:功能与病理学。  |  Schäfer, BW. and Heizmann, CW. 1996. Trends Biochem Sci. 21: 134-40. PMID: 8701470
  11. 血液恶性肿瘤中的 CDKN2(MTS1/p16INK4A)基因改变。  |  Uchida, T., et al. 1997. Leuk Lymphoma. 24: 449-61. PMID: 9086436
  12. Mts1 对非肌肉肌球蛋白 II 结构和活性的影响  |  Ford, HL., et al. 1997. Biochemistry. 36: 16321-7. PMID: 9405067

订购信息

产品名称产品编号规格价格数量收藏夹

Mts1 抗体 (A-7)

sc-377059
200 µg/ml
RMB2377.00

Mts1 抗体 (A-7) AC

sc-377059 AC
500 µg/ml, 25% agarose
RMB3129.00

Mts1 抗体 (A-7) HRP

sc-377059 HRP
200 µg/ml
RMB2377.00

Mts1 抗体 (A-7) FITC

sc-377059 FITC
200 µg/ml
RMB2482.00

Mts1 抗体 (A-7) PE

sc-377059 PE
200 µg/ml
RMB2580.00

Mts1 抗体 (A-7) Alexa Fluor® 488

sc-377059 AF488
200 µg/ml
RMB2685.00

Mts1 抗体 (A-7) Alexa Fluor® 546

sc-377059 AF546
200 µg/ml
RMB2685.00

Mts1 抗体 (A-7) Alexa Fluor® 594

sc-377059 AF594
200 µg/ml
RMB2685.00

Mts1 抗体 (A-7) Alexa Fluor® 647

sc-377059 AF647
200 µg/ml
RMB2685.00

Mts1 抗体 (A-7) Alexa Fluor® 680

sc-377059 AF680
200 µg/ml
RMB2685.00

Mts1 抗体 (A-7) Alexa Fluor® 790

sc-377059 AF790
200 µg/ml
RMB2685.00

Is the antibody also suitable for mouse and rat? Thank you.

Asked by: jw25
Thank you for your question. This antibody has not been tested for mouse and rat use, and can therefore not be warrantied for this use. If you have any further questions, please contact Technical Service.
Answered by: Technical Support
Date published: 2018-12-11

I am using Mts1 (A-7): sc-377059 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Randy McDonald
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from 美しいバンドが検出されます。WBで使用しました。シャープなバンドが検出されました。非特異的なバンドは一切ありません。バンドの大きさもデータシートと同じ位置です。
Date published: 2020-12-01
Rated 5 out of 5 by from Good band in westernGood band observed in Western blot with a whole lysates from human HeLa cells
Date published: 2018-01-29
Rated 5 out of 5 by from OutstandingIt is an excellent antibody. I am very satisfied and low background.
Date published: 2017-10-28
Rated 5 out of 5 by from Very Strong Signal in WBThis antibody is well-cited for a variety of applications including WB, IP, IF, and even IHC and ELISA. Strong, clear signal with little to no background. Beautiful tissue staining.
Date published: 2017-02-03
Rated 4 out of 5 by from Color is not too fast.I use us of the antibody,1:200 diluted antibody do immunohistochemical,the result came out,but color is not too fast ,1:800diluted antibody do western blot ,the result didn't come out.
Date published: 2017-01-12
Rated 4 out of 5 by from Able to obtain expected bands in controlsAble to obtain expected bands in controls, but seems to be some lot variation unexpected for a monoclonal.
Date published: 2015-04-03
Rated 5 out of 5 by from Great immunoperoxidase cytoplasmic and nuclearGreat immunoperoxidase cytoplasmic and nuclear staining in formalin fixed, paraffin-embedded human tonsil tissue. -SCBT QC
Date published: 2015-02-16
Rated 5 out of 5 by from Satisfactory Western Blot data of Mts1 expressionSatisfactory Western Blot data of Mts1 expression in HeLa and A549 whole cell lysates. -SCBT QC
Date published: 2014-11-26
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Mts1 抗体 (A-7) is rated 4.8 out of 5 by 8.
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