Date published: 2025-9-8

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MSH2 抗体 (E-7): sc-365052

5.0(3)
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说明书
  • MSH2抗体(E-7)是小鼠单克隆IgG3 κ, 在3篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的MSH2的N-terminus的氨基酸2-28之间
  • 推荐用于 mouse, rat 和 human 来源的MSH2 WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: canine
  • m-IgG3 BP-HRPm-IgGκ BP-HRP是MSH2 Antibody (E-7) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与MSH2 Antibody (E-7) 打包提供(请参阅下面的订购信息)。

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関連項目

发现DNA错配修复基因的突变与遗传性非息肉病性结直肠癌(HNPCC)有关后,人们对DNA错配修复机制的理解产生了浓厚的兴趣。最初,在HNPCC中高频检测到细菌DNA错配修复基因MutS和MutL的MSH2和MLH1同源物的遗传性突变,并显示这些突变与微卫星不稳定性有关。有证据表明,10%至45%的胰腺癌、胃癌、乳腺癌、卵巢癌和小细胞肺癌也表现出微卫星不稳定性,这表明DNA错配修复不仅限于HNPCC肿瘤,而是肿瘤发生或进展的一个共同特征。已经确定了原核MutL基因的两个额外同源物,分别命名为PMS1和PMS2,并显示它们在HNPCC患者的生殖系中发生突变。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MSH2 抗体 (E-7) 参考文献:

  1. 原发性前列腺癌中的MSH2缺失。  |  Guedes, LB., et al. 2017. Clin Cancer Res. 23: 6863-6874. PMID: 28790115
  2. MSH2在拟南芥中与同源间多态性相关的减数分裂交叉景观。  |  Blackwell, AR., et al. 2020. EMBO J. 39: e104858. PMID: 32935357
  3. OTUB1 通过阻止泛素化稳定错配修复蛋白 MSH2。  |  Wu, Q., et al. 2021. J Biol Chem. 296: 100466. PMID: 33640455
  4. CircLIFR与MSH2协同作用,通过膀胱癌中的MutSα/ATM-p73轴来减弱耐药性。  |  Zhang, H., et al. 2021. Mol Cancer. 20: 70. PMID: 33874956
  5. Mlh1与Msh2和Msh6相互作用,在错配修复过程中进行招募。  |  DuPrie, ML., et al. 2022. DNA Repair (Amst). 119: 103405. PMID: 36122480
  6. MSH2是卵巢癌易感基因,发病年龄很小,而不是BRCA1。  |  Flaum, N., et al. 2023. J Med Genet. 60: 576-577. PMID: 36894311
  7. MLH1和MSH2水平与结直肠癌的临床病理特征的相关性。  |  Guo, L., et al. 2023. Am J Transl Res. 15: 1107-1116. PMID: 36915797
  8. MSH2刺激干扰并抑制非干扰交叉反应,以应对遗传多态性。  |  Dluzewska, J., et al. 2023. Nat Commun. 14: 6716. PMID: 37872134
  9. MSH2中不寻常反转的功能和表型后果。  |  Pelletier, D., et al. 2024. Fam Cancer. 23: 1-7. PMID: 37957483
  10. Lnc-PTCHD4-AS抑制胃癌,通过MSH2-MSH6二聚化和ATM-p53-p21激活。  |  Wang, J., et al. 2023. Aging (Albany NY). 15: 13558-13578. PMID: 38016120

订购信息

产品名称产品编号规格价格数量收藏夹

MSH2 抗体 (E-7)

sc-365052
200 µg/ml
RMB2377.00

MSH2 (E-7): m-IgGκ BP-HRP 套装

sc-535139
200 µg Ab; 40 µg BP
RMB2662.00

MSH2 (E-7): m-IgG3 BP-HRP 套装

sc-550306
200 µg Ab; 40 µg BP
RMB2662.00

MSH2 (E-7) 中和勝肽

sc-365052 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-365052 P appropriate for?

Asked by: AbPolly
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from WB publishable data with human U2OSWB publishable data with human U2OS - SCBT Publication Review
Date published: 2015-04-10
Rated 5 out of 5 by from Strong band in WB in 293 whole cell lysatesStrong band in WB in 293 whole cell lysates and HeLa and HepG2 nuclear extracts. -SCBT QC
Date published: 2015-01-29
Rated 5 out of 5 by from Excellent immunofluorescence nuclear stainingExcellent immunofluorescence nuclear staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2014-08-24
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MSH2 抗体 (E-7) is rated 5.0 out of 5 by 3.
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