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MRP1 Antibody (QCRL-3) - Flow Cytometry - Image 5998
MRP1 抗体 (QCRL-3) PE: sc-18873 PE. 人体外周血白细胞的 FCM 分析. 象限标记根据同型对照正常小鼠 IgG2a: sc-2867 设置.
MRP1 Antibody (QCRL-3) - Flow Cytometry - Image 5998
MRP1 抗体 (QCRL-3) PE: sc-18873 PE. 人体外周血白细胞的 FCM 分析. 象限标记根据同型对照正常小鼠 IgG2a: sc-2867 设置.
MRP1 Antibody (QCRL-3) - Immunofluorescence - Image 11404
MRP1 抗体 (QCRL-3): sc-18873. 甲醇固定的 T98G 细胞免疫荧光染色, 显示膜定位.
MRP1 抗体 (QCRL-3) PE: sc-18873 PE. 人体外周血白细胞的 FCM 分析. 象限标记根据同型对照正常小鼠 IgG2a: sc-2867 设置.

MRP1 抗体 (QCRL-3): sc-18873

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寫評論提問

说明书
  • MRP1抗体(QCRL-3)是小鼠单克隆IgG2a κ, 在5篇文献中引用，规格为200 µg/ml
  • 针对human小细胞肺癌细胞系H69AR制备的膜（高度表达MRP1）
  • 推荐用于 human 来源的MRP1 IF 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 看 MRP1 (QCRL-1): sc-18835，可查看有标记的 MRP1 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP、 2a BP-HRP">m-IgG2a BP-HRP和m-IgGκ BP-HRP是MRP1 Antibody (QCRL-3). 的首选辅助检测试剂。这些试剂现与MRP1 Antibody (QCRL-3) 打包提供（请参阅下面的订购信息）。

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関連項目

额外MRP抗体，包括MRP1, MRP2, MRP3, MRP4, MRP5和MRP6

已知ABC转运蛋白家族中两个成员使人类癌细胞产生多药耐药性，它们分别是Mdr-1 P-糖蛋白和多药耐药蛋白MRP1。MRP1是一个整合膜蛋白，包含一个类似Mdr的核心、一个N末端膜结合区和一个细胞质连接器，它在各种脑细胞以及肺、睾丸和外周血中均有表达。MRP基因家族还包括MRP2和MRP3，MRP2被命名为cMOAT（用于肾小管多特异性有机阴离子转运子），它们都是偶联输出泵，主要在肝细胞中表达。MRP2仅定位于顶膜，在正常肝细胞中具有稳定的高表达。相反，MRP3定位于基底膜，并介导有机阴离子S-(2,4-二硝基苯基)-谷胱甘肽向基底膜的转运。正常情况下，MRP3表达水平比MRP2低，只有当MRP2在顶膜分泌受到损害时，MRP3才会增加。MRP6蛋白在肝脏和肾脏中高表达，而MRP4和MRP5则在各种组织中被检测到，但表达水平较低。

仅限研究使用。不适用于诊断和治疗用途。

订购信息

产品名称产品编号规格价格数量收藏夹

MRP1 抗体 (QCRL-3)

sc-18873
200 µg/ml
RMB2377.00

MRP1 (QCRL-3): m-IgG Fc BP-HRP 套装

sc-536604
200 µg Ab; 10 µg BP
RMB2662.00

MRP1 (QCRL-3): m-IgGκ BP-HRP 套装

sc-533759
200 µg Ab; 40 µg BP
RMB2662.00

MRP1 (QCRL-3): m-IgG2a BP-HRP 套装

sc-547842
200 µg Ab; 10 µg BP
RMB2662.00

MRP1 抗体 (QCRL-3) FITC

sc-18873 FITC
200 µg/ml
RMB2482.00

MRP1 抗体 (QCRL-3) PE

sc-18873 PE
200 µg/ml
RMB2580.00

I was wondering if the antibody MRP1 (xQRCL-3): sc-18873 recognizes an extra or intracellular epitope ? Because we want to use it for flux cytometry, but we do not want to permeabilize our cells. Thank you

Asked by: Hugosugier
Thank you for your question. This antibody was raised against membranes prepared from the human small cell lung cancer cell line, H69AR, which highly overexpresses MRP1. The exact epitope has not been mapped, so further information is not available.
Answered by: Tech Service
Date published: 2019-07-03

what is the difference between MRP1 Antibody (xQCRL3):sc-18873 and (QCRL1):sc-18835? My target is H69AR resistant to adryamycin, which one is better? I'll use FCM technique, better to buy sc-18873 FITC or buy m-IgGκ BP-FITC: sc-516140 separately? thanks

Asked by: leonardo23
Thank you for your question. These are two different monoclonal antibodies. They recognize distinct epitopes and are suitable for different applications. We do not have any recommendation for antibodies to detect H69AR resistant to adryamycin. If you would like to detect MRP1 by FCM then we do recommend using a directly conjugated primary antibody. For example, sc-18873 FITC, or sc-18835 FITC.
Answered by: Technical Support
Date published: 2019-01-26

How can MRP1 (QCRL-3): sc-18873 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: Germaine
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to phycoerythrin (sc-18873 PE) or fluoroscein (sc-18873 FITC).
Answered by: Technical Support
Date published: 2017-02-28
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Rated 4 out of 5 by from Published IHC(P) data for use in human liverPublished IHC(P) data for use in human liver. -SCBT Publication Review
Date published: 2015-03-22
Rated 4 out of 5 by from Published data for WB in human CL3 cellsPublished data for WB in human CL3 cells. -SCBT Publication Review
Date published: 2015-03-15
Rated 4 out of 5 by from Produced wonderful immunofluorescence membraneProduced wonderful immunofluorescence membrane staining in methanol-fixed T98G cells. -SCBT QC
Date published: 2015-02-19
Rated 4 out of 5 by from Great FCM data of human peripheral bloodGreat FCM data of human peripheral blood leukocytes. -SCBT QC
Date published: 2014-08-21
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MRP1 抗体 (QCRL-3) is rated 4.0 out of 5 by 4.
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