Date published: 2025-9-7

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Moesin 抗体 (E-10): sc-13122

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说明书
  • Moesin 抗体 E-10 是小鼠单克隆 IgM κ,Moesin抗体, 在13篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Moesin的C-terminus的氨基酸512-526之间
  • 推荐用于 mouse, rat 和 human 来源的Moesin WB, IP, IF 和 IHC(P)检测; 也和以下物种反应,包括: 和 equine, canine, bovine and porcine
  • 另提供琼脂糖偶联抗体,规格为琼脂糖装,可用于IP实验;HRP 偶联抗体用于WB, IHC(P)和ELISA实验;以及藻红蛋白、FITC、Alexa Fluor® 488Alexa Fluor® 647 偶联抗体,规格为用于IF、IHC(P)和FCM实验
  • 关于如何获取Moesin (E-10): sc-13122免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成Moesin 抗体 (E-10)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

Moesin 抗体 (E-10) 是一种小鼠单克隆 IgM kappa 轻链抗体,可通过免疫印迹 (WB)、免疫沉淀 (IP)、免疫荧光 (IF) 和免疫组织化学检测小鼠、大鼠和人类来源的 Moesin 蛋白。抗Moesin抗体(E-10)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。Moesin与Ezrin和Radixin同属于高度同源的肌动蛋白相关蛋白家族,这些蛋白位于质膜下方,在连接细胞骨架和质膜方面发挥着关键作用。这种相互作用对于维持细胞形状、促进细胞信号传导和促进细胞运动至关重要,而细胞运动是发育和组织修复过程中的重要过程。值得注意的是,Moesin参与调节细胞粘附和迁移,使其成为包括癌症转移在内的各种生理和病理过程中的关键参与者。尽管Moesin、Ezrin和Radixin具有高度同源性,但它们表现出独特的受体特异性磷酸化模式,这凸显了它们调节机制的复杂性以及在细胞功能中的特定作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Moesin 抗体 (E-10) 参考文献:

  1. 由 ezrin, radixin 和 moesin 组成的基因家族。其特异性定位在肌动蛋白丝/质膜结合部位。  |  Sato, N., et al. 1992. J Cell Sci. 103 (Pt 1): 131-43. PMID: 1429901
  2. Moesin:4.1-talin-ezrin 蛋白家族的成员。  |  Lankes, WT. and Furthmayr, H. 1991. Proc Natl Acad Sci U S A. 88: 8297-301. PMID: 1924289
  3. 蛋白-酪氨酸激酶底物 ezrin 的 cDNA 克隆和测序显示其与带 4.1 同源。  |  Gould, KL., et al. 1989. EMBO J. 8: 4133-42. PMID: 2591371
  4. 通过Hsp90ab1/moesin介导的TGFβ/FN1/CD44信号抑制成骨细胞蛋白质组抑制乳腺癌相关骨质流失。  |  Sun, X., et al. 2022. Theranostics. 12: 929-943. PMID: 34976221
  5. 肿瘤代谢产物乳酸通过调节MOESIN的乳化和增强调节性T细胞中的TGF-β信号传导来促进肿瘤发生。  |  Gu, J., et al. 2022. Cell Rep. 39: 110986. PMID: 35732125
  6. 硫化氢修饰的M2外泌体通过moesin介导的内吞作用促进骨再生  |  Zhou, YK., et al. 2024. Bioact Mater. 31: 192-205. PMID: 37593496
  7. FBXW2通过靶向AKT-Moesin-SKP2轴抑制乳腺癌发生。  |  Barik, GK., et al. 2023. Cell Death Dis. 14: 623. PMID: 37736741
  8. ERM家族成员是细胞表面糖蛋白CD44和基于肌动蛋白的细胞骨架之间的分子连接体。  |  Tsukita, S., et al. 1994. J Cell Biol. 126: 391-401. PMID: 7518464
  9. Ezrin 具有在质膜上自我结合的特性。  |  Andréoli, C., et al. 1994. J Cell Sci. 107 (Pt 9): 2509-21. PMID: 7844168
  10. Ezrin 含有细胞骨架和膜结合结构域,因此被认为具有膜-骨架连接体的作用。  |  Algrain, M., et al. 1993. J Cell Biol. 120: 129-39. PMID: 8416983
  11. 酪氨酸激酶底物的 ezrin 样家族:受体特异性酪氨酸磷酸化模式及与恶性转化的关系。  |  Fazioli, F., et al. 1993. Oncogene. 8: 1335-45. PMID: 8479753
  12. Ezrin 是一种环磷酸腺苷依赖性蛋白激酶锚定蛋白。  |  Dransfield, DT., et al. 1997. EMBO J. 16: 35-43. PMID: 9009265

订购信息

产品名称产品编号规格价格数量收藏夹

Moesin 抗体 (E-10)

sc-13122
200 µg/ml
RMB2377.00

Moesin 抗体 (E-10) AC

sc-13122 AC
500 µg/ml, 25% agarose
RMB3129.00

Moesin 抗体 (E-10) Alexa Fluor® 488

sc-13122 AF488
200 µg/ml
RMB2685.00

Moesin 抗体 (E-10) Alexa Fluor® 647

sc-13122 AF647
200 µg/ml
RMB2685.00

Moesin 抗体 (E-10) FITC

sc-13122 FITC
200 µg/ml
RMB2482.00

Moesin 抗体 (E-10) HRP

sc-13122 HRP
200 µg/ml
RMB2377.00

Moesin (E-10) 中和勝肽

sc-13122 P
100 µg/0.5 ml
RMB511.00

Moesin 抗体 (E-10) PE

sc-13122 PE
200 µg/ml
RMB2580.00

What application is the blocking peptide sc-13122 P appropriate for?

Asked by: Professor Griffin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Great AbVery good antibody for WB in human neural stem cells
Date published: 2017-11-28
Rated 5 out of 5 by from work welli bought the product and did a good data ,a really good antibidy
Date published: 2017-07-07
Rated 5 out of 5 by from Strong staining in IF in human colorectal tissuesStrong staining in IF in human colorectal tissues, normal and tumor. -SCBT Publication Review
Date published: 2015-05-20
Rated 5 out of 5 by from Good specificity in WB in rat Thoracic aortasGood specificity in WB in rat Thoracic aortas. -SCBT Publication Review
Date published: 2015-04-09
Rated 5 out of 5 by from Good publishable data in WB in human BreastGood publishable data in WB in human Breast Cancer (MDA-MB-231). -SCBT Publication Review
Date published: 2015-02-28
Rated 5 out of 5 by from Excellent immunoperoxidase cytoplasmic stainingExcellent immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human esophagus tissue. -SCBT QC
Date published: 2015-01-22
Rated 5 out of 5 by from Strong band in WB in rat uterusStrong band in WB in rat uterus. -SCBT Publication Review
Date published: 2015-01-18
Rated 5 out of 5 by from Strong signal strength in WB in HelaStrong signal strength in WB in Hela, A-431, Jurkat and NIH/3T3 whole cell lysates. -SCBT QC
Date published: 2015-01-16
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Moesin 抗体 (E-10) is rated 5.0 out of 5 by 8.
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