Date published: 2025-9-9

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MMP-8 抗体 (B-1): sc-514803

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说明书
  • MMP-8抗体(B-1)是小鼠单克隆IgM κ, 在6篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列122-166位于human物种的MMP-8的内部区域内
  • 推荐用于 mouse, rat 和 human 来源的MMP-8 WB, IP, IF 和 ELISA检测
  • 看 MMP-1/8 (A-7): sc-137044,可查看有标记的 MMP-8 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 关于如何获取MMP-8 (B-1): sc-514803免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP是MMP-8 Antibody (B-1) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与MMP-8 Antibody (B-1) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGκ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。

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関連項目

MMP-8抗体(B-1)是一种小鼠单克隆IgM抗体,可通过应用诸如蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)等方法检测小鼠、大鼠和人类样本中的MMP-8。抗MMP-8抗体(B-1)以非结合形式提供,可用于多种实验。MMP-8,也称为中性粒细胞胶原酶或胶原酶-2,在降解I、II和III型纤维胶原中起着至关重要的作用,而纤维胶原对于组织重塑和修复至关重要。MMP-8主要在炎症条件下表达,这凸显了它在伤口愈合和产后子宫回缩等过程中的重要性。多种刺激会影响MMP-8的表达,包括激活基因转录的苯酚酯和脂多糖。MMP-8的活性取决于钙离子和锌离子,而这两种离子对于催化功能至关重要。了解MMP-8的动态变化及其与细胞外基质中其他蛋白的相互作用有助于深入了解病理状况,因此MMP-8(B-1)抗体成为研究人员研究炎症和组织修复机制的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MMP-8 抗体 (B-1) 参考文献:

  1. 人类中性粒细胞胶原酶。一种与其他基质金属蛋白酶同源性的独特基因产物。  |  Hasty, KA., et al. 1990. J Biol Chem. 265: 11421-4. PMID: 2164002
  2. 基质金属蛋白酶(MMP-8、MMP-9、MMP-13)在牙周和种植体周围病理过程中的作用。  |  Luchian, I., et al. 2022. Int J Mol Sci. 23: PMID: 35163727
  3. 慢性硬膜下血肿中MMP-8和MMP-9的免疫表达。  |  Su, GJ., et al. 2022. Front Neurol. 13: 988854. PMID: 36061997
  4. 活性MMP-8作为种植体周围健康或疾病的生物标志物。  |  Xanthopoulou, V., et al. 2023. Eur J Dent. 17: 924-928. PMID: 36063841
  5. 循环骨髓来源的MMP8在应激易感性和抑郁症中的作用。  |  Cathomas, F., et al. 2024. Nature. 626: 1108-1115. PMID: 38326622
  6. 金属蛋白酶8(MMP-8)在牙周炎诊断中的重要性。  |  Zalewska, EA., et al. 2024. Int J Mol Sci. 25: PMID: 38473967
  7. PRP中的外泌体miRNA-26b-5p通过靶向MMP-8来抑制NETs,从而促进糖尿病伤口愈合。  |  Rui, S., et al. 2024. J Control Release. 372: 221-233. PMID: 38909697
  8. N末端在胶原酶 '超活化 '过程中作用的结构含义。晶体学研究。  |  Reinemer, P., et al. 1994. FEBS Lett. 338: 227-33. PMID: 8307185
  9. 基质金属蛋白酶:综述。  |  Birkedal-Hansen, H., et al. 1993. Crit Rev Oral Biol Med. 4: 197-250. PMID: 8435466
  10. 人类单核细胞中几种基质金属蛋白酶基因的表达。  |  Machein, U. and Conca, W. 1997. Adv Exp Med Biol. 421: 247-51. PMID: 9330704
  11. 小鼠组织重塑过程中胶原酶 2(MMP-8)的表达。分析其在产后子宫内陷中的潜在作用。  |  Balbín, M., et al. 1998. J Biol Chem. 273: 23959-68. PMID: 9727011
  12. MMP-8 是愈合伤口和未愈合溃疡中最主要的胶原酶。  |  Nwomeh, BC., et al. 1999. J Surg Res. 81: 189-95. PMID: 9927539

订购信息

产品名称产品编号规格价格数量收藏夹

MMP-8 抗体 (B-1)

sc-514803
200 µg/ml
RMB2377.00

MMP-8 (B-1): m-IgGκ BP-HRP 套装

sc-524847
200 µg Ab, 40 µg BP
RMB2662.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with MMP-8 (B-1): sc-514803 monoclonal antibody?

Asked by: Dr Ninau Qelp
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2021-11-10
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Rated 5 out of 5 by from Good for WB for human samplesI used this antibody for WB of a sample of human fibroblasts for detection and got a good band at the expected MW.
Date published: 2024-09-25
Rated 5 out of 5 by from Good for Western BlotAntibody detects a band at the expected molecular weight of latent MMP-8 in A2058 and HCT-116 whole cell lysates. Shown with Cruz Marker molecular weight standards, sc-2035. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from Great mmp8 antibodyi got a very great result with this antibody in colon tissue.
Date published: 2018-11-08
Rated 5 out of 5 by from excellent antibodyI got 10ug free sample use for the pig colon and heart blood vessel cryosections immunofluorescence stain. The result images are very good.
Date published: 2017-09-11
Rated 5 out of 5 by from good sample antibodyI use this sample antibody for WB , I got desire bands for WB at 1:500 diluted.
Date published: 2017-02-11
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MMP-8 抗体 (B-1) is rated 5.0 out of 5 by 5.
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