Date published: 2026-11-7

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MITF Antibody (4H205) - Western Blotting - Image 143379
MITF 抗体 (4H205): sc-71587. Jurkat (A) 和 SK-MEL-28 (B) 核提取物中 MITF 表达的 Western 印迹分析.
MITF Antibody (4H205) - Western Blotting - Image 143379
MITF 抗体 (4H205): sc-71587. Jurkat (A) 和 SK-MEL-28 (B) 核提取物中 MITF 表达的 Western 印迹分析.
MITF Antibody (4H205) - Western Blotting - Image 38612
MITF 抗体 (4H205): sc-71587. Western 印迹分析 Jurkat 核提取物中 MITF 的表达.
MITF 抗体 (4H205): sc-71587. Jurkat (A) 和 SK-MEL-28 (B) 核提取物中 MITF 表达的 Western 印迹分析.

MITF 抗体 (4H205): sc-71587

4.3(3)
寫評論提問
说明书
  • MITF 抗体 4H205 是小鼠单克隆 IgG1, 在1篇文献中引用，提供 100 µg/ml
  • 针对氨基酸408-419 MITF human
  • 推荐WB 和 IP检测mouse, rat, human, avian 和 Xenopus来源的MITF; 也和以下物种反应，包括： 和 equine, bovine and canine
  • 目前，我们还没有完成MITF 抗体 (4H205)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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関連項目

MITF（小眼畸形相关转录因子）是一种含有碱性螺旋-环-螺旋（HLH）和亮氨酸拉链（LZ）结构域的黑素细胞核蛋白。这些蛋白质基序在其他转录因子中经常被观察到，在Myc家族成员中尤为常见。 MITF可作为同二聚体直接与DNA结合，是黑素细胞发育和分化的必要条件。其表达由cAMP和cAMP依赖性途径上调。 MITF通过结合其E-box激活几种不同的基因启动子。酪氨酸酶、TRP1和TRP2是MITF激活的色素合成基因。当Ser73上的MITF被磷酸化时（通过MAPK途径），它与p300/CBP家族的共激活因子结合并增强转录。 MITF具有几种同工型，包括在黑素细胞中特异性表达的MITF-M。在MITF缺陷小鼠中，黑素细胞完全缺失。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MITF 抗体 (4H205) 参考文献:

  1. 种系致癌MITF突变与肿瘤易感性。  |  Paillerets, BB., et al. 2014. Eur J Cell Biol. 93: 71-5. PMID: 24290354
  2. MITF家族转录因子：在溶酶体生物发生、Wnt信号传导和肿瘤发生中的作用。  |  Ploper, D. and De Robertis, EM. 2015. Pharmacol Res. 99: 36-43. PMID: 26003288
  3. MITF-M调控小鼠黑素细胞的黑色素生成。  |  Chen, T., et al. 2018. J Dermatol Sci. 90: 253-262. PMID: 29496358
  4. 皮肤中的MITF和紫外线反应：从色素沉着到成瘾。  |  Nguyen, NT. and Fisher, DE. 2019. Pigment Cell Melanoma Res. 32: 224-236. PMID: 30019545
  5. 视网膜色素上皮细胞（RPE）功能与功能障碍中的转录因子MITF。  |  Ma, X., et al. 2019. Prog Retin Eye Res. 73: 100766. PMID: 31242455
  6. 黑色素细胞和黑色素瘤中的内溶酶体阳离子通道和MITF。  |  Abrahamian, C. and Grimm, C. 2021. Biomolecules. 11: PMID: 34356645
  7. MiTF/TFE易位肾细胞癌：从临床实体到分子见解。  |  Simonaggio, A., et al. 2022. Int J Mol Sci. 23: PMID: 35886994
  8. 在多基因风险评分时代，MC1R和MITF等位基因共同决定黑色素瘤风险。  |  Bruno, W. 2023. Br J Dermatol. 188: 696-697. PMID: 36975215
  9. MRGPRX2信号传导涉及赖氨酰-tRNA合成酶和MITF通路。  |  Guo, Y., et al. 2023. Front Immunol. 14: 1154108. PMID: 37234172
  10. MITF作为免疫关键调节因子的新兴作用。  |  Lee, A., et al. 2024. Exp Mol Med. 56: 311-318. PMID: 38351314

订购信息

产品名称产品编号规格价格数量收藏夹

MITF 抗体 (4H205)

sc-71587
100 µg/ml
CNY2422.00

Do you sell a small size of this MiTF Ab (sc-71587)?

Asked by: ND_WCM
Thank you for your question. No, we do not sell a smaller size. The smallest size available for this antibody is 100 ug in 1 ml. We do offer some free 10 ug sample sizes for alternative MITF antibodies, including: sc-515925, sc-52938 and sc-56726. Please contact our Technical Service Department for more information on how to receive a free 10 ug samples of monoclonal antibodies.
Answered by: Technical Support
Date published: 2019-07-24

For Western Blot, is it recommended to use denatured or non-denatured conditions with MITF (4H205): sc-71587 antibody?

Asked by: Professor Griffin
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by Randy McDonald from good results at correct molecular weightWe used this antibody for a western blot experiment and got nice dark bands in Jurkat cells at the correct molecular weight
Date published: 2017-01-19
Rated 3 out of 5 by MS from Faint positive signal in western blot usingFaint positive signal in western blot using Jurkat whole cell lysates. -SCBT QC
Date published: 2015-05-27
Rated 5 out of 5 by FL from StrongStrong, clean bands in western blot analysis of MITF expression in Jurkat and SK-MEL-28 nuclear extracts. -SCBT QC
Date published: 2014-03-08
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MITF抗体 (4H205) is rated 4.3 out of 5 by 3.
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