Metoclopramide (CAS 364-62-5)

外观 :

Crystalline powder

物理状态 :

Solid

溶解度 :

Soluble in water (miscible), and ethanol.

保存 :

Store at room temperature

熔点 :

147.2-147.8° C

沸点 :

~418.7° C at 760 mmHg (Predicted)

密度 :

~1.2 g/cm³ (Predicted)

折射率 :

n²⁰_D 1.55 (Predicted)

IC50 :

D2DR: IC₅₀ = 127 nM (human); D3DR: IC₅₀ = 200 nM (human); Serotonin 3 receptor: IC₅₀ = 228 nM (rat); SR-2B: IC₅₀ = 630 nM (human); Cytochrome P450 2D6: IC₅₀ = 800 nM (human)

Ki 数据 :

D3DR: K_i= 27 nM (human); D2DR: K_i= 42 nM (human); Serotonin 3 receptor : K_i= 200 nM (mouse); Serotonin 4 receptor: K_i= 546 nM (Cavia porcellus); CYP2D6: K_i= 960 nM (human)

pK值 :

pK_a: 13.84 (Predicted), pK_b: 9.08 (Predicted)

德国水公害等级 :

3

PubChem CID :

MDL 号码 :

MFCD00211338

EC号码 :

206-662-9

Beilstein 注册 :

1884366

SMILES :

CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl