Date published: 2025-9-7

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MetAP-2 抗体 (F-7): sc-365637

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说明书
  • MetAP-2 抗体 F-7 是小鼠单克隆 IgG1 κ,MetAP-2抗体, 在2篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的MetAP-2的内部区域内的氨基酸152-183之间
  • MetAP-2 抗体 (F-7) 推荐用于WB, IP, IF, IHC(P) 和 ELISA ,检测 mouse, rat, human 和 avian来源的MetAP-2; 也和以下物种反应,包括: 和 equine, canine, bovine, porcine and avian
  • 抗MetAP-2抗体(F-7)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取MetAP-2 (F-7): sc-365637免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是MetAP-2 Antibody (F-7) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与MetAP-2 Antibody (F-7) 打包提供(请参阅下面的订购信息)。

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関連項目

MetAP-2抗体(F-7)是一种IgG1κ小鼠单克隆MetAP-2单克隆抗体,通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人来源的MetAP-2蛋白。MetAP-2抗体(F-7)既有非偶联的抗MetAP-2的抗体形式,也有多种偶联的抗MetAP-2抗体形式,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。蛋氨酸氨肽酶(MetAP),也称为肽酶M蛋白,是M24蛋白家族的成员。MetAP-1和MetAP-2都从新生肽和芳基胺中释放N-末端氨基酸,通常是甲硫氨酸。真核生物同时含有MetAP-1和MetAP-2,而原核生物仅具有MetAP-1酶。MetAP-1和MetAP-2控制哺乳动物细胞中的细胞增殖。MetAP-2在人类和酿酒酵母之间高度保守。神经纤维蛋白(NF1)调节MetAp-2,MetAp-2表达增加与多种形式的癌症相关。MetAP-2抑制剂是癌症治疗的潜在靶点,特别是在NF1相关的肿瘤增殖中。化学治疗药物,如ovalicin和fumagillin与MetAp-2的活性位点结合并抑制MetAp-2。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MetAP-2 抗体 (F-7) 参考文献:

  1. 针对蛋氨酸氨肽酶 2(MetAP2)的新型抑制剂可在异种移植裸鼠模型中强力抑制癌症的生长。  |  Chun, E., et al. 2005. Int J Cancer. 114: 124-30. PMID: 15523682
  2. 在临床前模型中,抑制蛋氨酸氨肽酶 2 是治疗神经母细胞瘤的有效策略。  |  Morowitz, MJ., et al. 2005. Clin Cancer Res. 11: 2680-5. PMID: 15814649
  3. 蛋氨酸氨肽酶 I 型和 II 型对控制细胞增殖至关重要。  |  Bernier, SG., et al. 2005. J Cell Biochem. 95: 1191-203. PMID: 15962312
  4. 对微孢子虫蛋氨酸氨肽酶 2 型的研究:微孢子虫病的治疗目标。  |  Zhang, H., et al. 2005. Folia Parasitol (Praha). 52: 182-92. PMID: 16004378
  5. 4-芳基-1,2,3-三唑:可逆蛋氨酸氨肽酶 2 抑制剂的新型模板,优化后可抑制体内血管生成。  |  Kallander, LS., et al. 2005. J Med Chem. 48: 5644-7. PMID: 16134930
  6. 抗血管生成药福马吉林能共价结合并抑制蛋氨酸氨肽酶 MetAP-2。  |  Sin, N., et al. 1997. Proc Natl Acad Sci U S A. 94: 6099-103. PMID: 9177176

订购信息

产品名称产品编号规格价格数量收藏夹

MetAP-2 抗体 (F-7)

sc-365637
200 µg/ml
RMB2377.00

MetAP-2 (F-7): m-IgG Fc BP-HRP 套装

sc-529419
200 µg Ab; 10 µg BP
RMB2662.00

MetAP-2 (F-7): m-IgGκ BP-HRP 套装

sc-522305
200 µg Ab, 40 µg BP
RMB2662.00

MetAP-2 (F-7): m-IgG1 BP-HRP 套装

sc-543506
200 µg Ab; 20 µg BP
RMB2662.00

MetAP-2 抗体 (F-7) AC

sc-365637 AC
500 µg/ml, 25% agarose
RMB3129.00

MetAP-2 抗体 (F-7) HRP

sc-365637 HRP
200 µg/ml
RMB2377.00

MetAP-2 抗体 (F-7) FITC

sc-365637 FITC
200 µg/ml
RMB2482.00

MetAP-2 抗体 (F-7) PE

sc-365637 PE
200 µg/ml
RMB2580.00

MetAP-2 抗体 (F-7) Alexa Fluor® 488

sc-365637 AF488
200 µg/ml
RMB2685.00

MetAP-2 抗体 (F-7) Alexa Fluor® 546

sc-365637 AF546
200 µg/ml
RMB2685.00

MetAP-2 抗体 (F-7) Alexa Fluor® 594

sc-365637 AF594
200 µg/ml
RMB2685.00

MetAP-2 抗体 (F-7) Alexa Fluor® 647

sc-365637 AF647
200 µg/ml
RMB2685.00

MetAP-2 抗体 (F-7) Alexa Fluor® 680

sc-365637 AF680
200 µg/ml
RMB2685.00

MetAP-2 抗体 (F-7) Alexa Fluor® 790

sc-365637 AF790
200 µg/ml
RMB2685.00

MetAP-2 (F-7) 中和勝肽

sc-365637 P
100 µg/0.5 ml
RMB511.00

What are the differences between MetAp-2 antibody (F-7) and MetAp-2 antibody (A-9)? there a difference regarding affinity or sensitivity for metap-2? Do they have different affinities for the enzyme?

Asked by: Bea Mun
Thank you for your question. These are very similar monoclonal antibodies, both raised against the same antigen for MetAP-2. They are different isotypes of mouse IgG, and the sc-365637: MetAP-2 (F-7) antibody is recommended for IHC(P), while the (A-9) clone has not yet been validated in that application. In addition, the sc-365637: MetAP-2 (F-7) antibody currently has a lot more data available, and one product citation.
Answered by: Technical Support
Date published: 2020-02-06

What application is the blocking peptide sc-365637 P appropriate for?

Asked by: Dr Ninau Qelp
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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