Date published: 2025-9-7

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MEI1 抗体 (F-4): sc-515359

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说明书
  • MEI1 抗体 F-4 是小鼠单克隆 IgA κ,MEI1抗体, 在1篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的MEI1的内部区域内的氨基酸518-534之间
  • 推荐用于 mouse, rat 和 human 来源的MEI1 WB, IP, IF 和 ELISA检测
  • 关于如何获取MEI1 (F-4): sc-515359免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP是MEI1 Antibody (F-4) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与MEI1 Antibody (F-4) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGκ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。

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関連項目

MEI1抗体(F-4)是一种小鼠单克隆IgA kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的MEI1蛋白。抗MEI1抗体(F-4)以非结合形式提供。MEI1,也称为减数分裂抑制蛋白1,在减数分裂的启动中起着至关重要的作用,它通过促进遗传编程的双链断裂的形成,而双链断裂对于配子形成过程中的染色体正确分离至关重要。这种1274个氨基酸的蛋白质主要在睾丸中表达,编码MEI1的基因缺陷会导致精子生成停滞和男性不育,这凸显了其在生殖健康中的重要性。值得注意的是,MEI1的基因变异与某些人群(如欧洲裔美国人)的不育有关,但与以色列男性无关,这表明遗传学与生育能力之间存在复杂的相互作用。此外,人类MEI1与其小鼠对应物具有79%的序列相似性,而选择性剪接则可产生7种不同的MEI1同工型,它们可能具有不同的功能和调节机制。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MEI1 抗体 (F-4) 参考文献:

  1. 小鼠减数分裂突变mei1会破坏染色体突触,从而对减数分裂的进展造成性别上的二态性后果。  |  Libby, BJ., et al. 2002. Dev Biol. 242: 174-87. PMID: 11820814
  2. 拟南芥 MEI1 基因编码一种具有五个 BRCT 结构域的蛋白质,该蛋白质参与减数分裂特异性 DNA 修复事件,与 SPO11 诱导的 DSB 无关。  |  Grelon, M., et al. 2003. Plant J. 35: 465-75. PMID: 12904209
  3. 小鼠正常减数分裂染色体突触所需的脊椎动物特异基因--Mei1的定位克隆和特征描述。  |  Libby, BJ., et al. 2003. Proc Natl Acad Sci U S A. 100: 15706-11. PMID: 14668445
  4. 在小鼠减数分裂过程中,Mei1 与 Dmc1 具有同源关系。  |  Reinholdt, LG. and Schimenti, JC. 2005. Chromosoma. 114: 127-34. PMID: 15928951
  5. 人类 MEI1 基因的多态等全基因与减数分裂停滞导致的人类无精子症有关。  |  Sato, H., et al. 2006. J Hum Genet. 51: 533-540. PMID: 16683055
  6. 影响雄性小鼠减数分裂的突变会影响前体中期和花束期的动力学。  |  Liebe, B., et al. 2006. Exp Cell Res. 312: 3768-81. PMID: 17010969
  7. 小鼠减数分裂检查点 2(trip13)需要完成减数分裂重组,但不需要完成突触。  |  Li, XC. and Schimenti, JC. 2007. PLoS Genet. 3: e130. PMID: 17696610
  8. 拟南芥减数分裂双股断裂的形成需要 AtPRD1。  |  De Muyt, A., et al. 2007. EMBO J. 26: 4126-37. PMID: 17762870

订购信息

产品名称产品编号规格价格数量收藏夹

MEI1 抗体 (F-4)

sc-515359
200 µg/ml
RMB2377.00

MEI1 (F-4): m-IgGκ BP-HRP 套装

sc-525012
200 µg Ab, 40 µg BP
RMB2662.00

MEI1 (F-4) 中和勝肽

sc-515359 P
100 µg/0.5 ml
RMB511.00

Can I re-use the blocking peptide? (for more than 1 experiment?)

Asked by: Beto
Thank you for your question. No, we would not recommend re-using the blocking peptides for more than one experiment. The blocking peptides are offered as negative controls for the antibodies. Once used they should neutralize the antigen binding sites of the corresponding antibody.
Answered by: Technical Support
Date published: 2017-11-02

What application is the blocking peptide sc-515359 P appropriate for?

Asked by: DefinitelyNotMatt
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-28
  • y_2025, m_9, d_7, h_4CST
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Rated 5 out of 5 by from Good for IHCAntibody works for Immunohistochemistry cell staining with mouse testis in published research. -SCBT QC
Date published: 2023-09-14
Rated 4 out of 5 by from specific band in WBI got this as free sample from Santa Cruz 2 months ago and it worked well in WB (1:50 dilution). Thanks Santa Cruz for this good product.
Date published: 2017-09-12
Rated 3 out of 5 by from Maybe it's good.Tried using spread and maybe the signal is correct.
Date published: 2017-08-02
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MEI1 抗体 (F-4) is rated 4.0 out of 5 by 3.
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