Megestrol Acetate (CAS 595-33-5)

外观 :

Powder

物理状态 :

Solid

溶解度 :

Soluble in water (<1 mg/ml at 25° C), DMSO (33 mg/ml at 25° C), ethanol (15 mg/ml at 25° C), chloroform (1:0.8), and methanol.

保存 :

Store at room temperature

熔点 :

214-216° C

沸点 :

507.07° C

密度 :

1.15 g/cm³

折射率 :

n²⁰_D 1.55

光学活性 :

α20_D +11±2, c = 2 in chloroform; α24_D +5 in chloroform

IC50 :

Progesterone receptor: IC₅₀ = 11 nM (bovine); GR: IC₅₀ = 19 nM (human); Androgen Receptor: IC₅₀ = 30 nM (rat); CYP2C9: IC₅₀ = 10 µM (human); HegG2: IC₅₀ = 260 µM

Ki 数据 :

Progesterone receptor: K_i= 1.44 nM (bovine); GR: K_i= 8.77 nM (human); Androgen Receptor: K_i= 20 nM (rat)

德国水公害等级 :

3

RTECS :

TU4075000

PubChem CID :

Merck 索引 :

14: 5805

MDL 号码 :

MFCD00056470

EC号码 :

209-864-5

Beilstein 注册 :

1917291

SMILES :

CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C