琥珀酸钠 MEG 可抑制 NOS2(iNOS)。MEG 丁二酸钠是一种过亚硝酸盐清除剂。
MEG sodium succinate (CAS 1190-74-5 (non-salt)) 参考文献
Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform: G.J. Southan, et al.; Br. J. Pharmacol. 117, 619 (1996) The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity: B. Zingarelli, et al.; Br. J. Pharmacol. 120, 357 (1997) Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage: C. Szabó, et al.; J. Biol. Chem. 272, 9030 (1997) ; Full Text Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation: S. Cuzzocrea, et al.; Free Radic. Biol. Med. 24, 450 (1998) Protective effects of MEG, a selective inhibitor of inducible nitric oxide synthase, in ligature-induced periodontitis in the rat [published erratum appears in Br. J. Pharmacol. 123, 741 (1998)]: Z. Lohinai, et al.; Br. J. Pharmacol. 123, 353 (1998) Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats: B. Zingarelli, et al.; J. Pharmacol. Exp. Ther. 287, 1048 (1998) Modulation of peroxynitrite- and hypochlorous acid-induced inactivation of alpha1-antiproteinase by mercaptoethylguanidine: M. Whiteman, et al.; Br. J. Pharmacol. 126, 1646 (1999)