Date published: 2025-9-7

021-6093-6350

SCBT Portrait Logo
Seach Input

MATH-1 抗体 (H-6): sc-514145

5.0(1)
寫評論提問

说明书
  • MATH-1抗体(H-6)是小鼠单克隆IgG3 (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于human物种的MATH-1的N-terminus附近的氨基酸52-77之间
  • 推荐用于 mouse, rat 和 human 来源的MATH-1 WB, IP, IF 和 ELISA检测
  • m-IgG3 BP-HRP是MATH-1 Antibody (H-6) 适用于 WB 应用。 的首选辅助检测试剂,该试剂现与MATH-1 Antibody (H-6) 搭配使用(请参阅下面的订购信息)。

    快捷链接

    関連項目

    果蝇的atonal基因产生一种具有基本螺旋-环-螺旋(bHLH)结构域的蛋白质,该蛋白质在果蝇神经系统的发育中起着至关重要的作用。哺乳动物的atonal同源物1(MATH-1)是一种螺旋-环-螺旋(HLH)转录因子,在结构上与果蝇的proneural基因atonal的产物同源。MATH-1,也被称为Atoh1、Ath1或HATH-1,是一种含有351个氨基酸的蛋白质,具有与atonal相关的基本HLH结构域。在小鼠中,MATH-1的表达发生在胚胎第9.5天,最初定位于颅神经节和中枢神经系统的背部。MATH-1的显著表达在中枢神经系统的背部,但在第18天时仅限于小脑的外颗粒层,并且在成年神经系统中无法检测到。这表明MATH-1可能通过激活E盒依赖性转录在神经细胞亚群的分化中发挥作用。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    MATH-1 抗体 (H-6) 参考文献:

    1. bHLH 基因 Math1 的异位表达干扰了神经发育。  |  Isaka, F., et al. 1999. Eur J Neurosci. 11: 2582-8. PMID: 10383648
    2. 神经营养素通过诱导碱性螺旋环螺旋转录因子 Mash1 和 Math1 的 mRNA 表达,促进培养的神经干细胞的神经元分化。  |  Ito, H., et al. 2003. J Neurosci Res. 71: 648-58. PMID: 12584723
    3. Math1通过调节Notch信号通路的多种成分来控制小脑颗粒细胞的分化。  |  Gazit, R., et al. 2004. Development. 131: 903-13. PMID: 14757642
    4. PC3 通过抑制细胞周期和诱导 Math1 对神经发生进行双重控制。  |  Canzoniere, D., et al. 2004. J Neurosci. 24: 3355-69. PMID: 15056715
    5. 肠特异性消融小鼠节律同源物1(Math1)揭示了其在细胞稳态中的作用。  |  Shroyer, NF., et al. 2007. Gastroenterology. 132: 2478-88. PMID: 17570220
    6. 利用新构建的非病毒基因递送质粒观察不同细胞类型中 Math1 蛋白的胞内运输。  |  Zhang, W., et al. 2011. J Gene Med. 13: 134-44. PMID: 21308898
    7. 在新生哺乳动物耳蜗中,Math1诱导的异位毛细胞样细胞主要涉及直接转分化。  |  Yang, J., et al. 2013. Neurosci Lett. 549: 7-11. PMID: 23669638
    8. 从 Math1 转染的小鼠 ES 细胞中诱导出内耳毛细胞样细胞。  |  Ouji, Y., et al. 2013. Cell Death Dis. 4: e700. PMID: 23828563
    9. 芳香烃受体对 Math1 的转录物调控:对小鼠小肠中 Math1+祖细胞的影响  |  Yagishita, Y., et al. 2023. Mol Cell Biol. 43: 43-63. PMID: 36720468
    10. S-100和MATH-1蛋白表达有助于预测神经母细胞瘤患者的临床预后  |  Sanlav, G., et al. 2024. J Pediatr Hematol Oncol. 46: 21-28. PMID: 37943051

    订购信息

    产品名称产品编号规格价格数量收藏夹

    MATH-1 抗体 (H-6)

    sc-514145
    200 µg/ml
    RMB2377.00

    MATH-1 (H-6): m-IgG3 BP-HRP 套装

    sc-550517
    200 µg Ab; 40 µg BP
    RMB2662.00

    MATH-1 (H-6) 中和勝肽

    sc-514145 P
    100 µg/0.5 ml
    RMB511.00

    What application is the blocking peptide sc-514145 P appropriate for?

    Asked by: Professor Griffin
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-27

    ¿Funciona este anticuerpo en tejidos incluidos en parafina y en cortes congelados? Gracias.

    Asked by: CBet
    Thank you for your question. MATH-1 Antibody (H-6): sc-514145 has not yet been tested on formalin-fixed paraffin-embedded tissue sections (or for IHC(P)). We do warranty this antibody for IF, or immunofluorescent staining of fresh or frozen tissue sections or cells fixed in acetone or methanol. Muchas gracias por su pregunta. El anticuerpo MATH-1 (H-6): sc-514145 no ha sido probado en cortes de tejido fijados en formaldehido incluidos en parafina (o para IHC (P). Ofrecemos una garantía para IF o inmunofluorescencia para tejidos frescos o congelados o para células fijadas en acetona o metanol.
    Answered by: Technical Support
    Date published: 2017-01-03
    • y_2025, m_8, d_30, h_9CST
    • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasquestionsanswers, tq_2
    • loc_zh_CN, sid_514145, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getContent, 115ms
    • QUESTIONS, PRODUCT
    Rated 5 out of 5 by from Great Western blot data of MATHGreat Western blot data of MATH-1 expression in NIH/3T3, PC-12, Jurkat and T-47D whole cell lysates and HeLa and Jurkat nuclear extracts. -SCBT QC
    Date published: 2013-11-22
    • y_2025, m_8, d_30, h_9
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_1
    • loc_zh_CN, sid_514145, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getReviews, 8ms
    • REVIEWS, PRODUCT
    MATH-1 抗体 (H-6) is rated 5.0 out of 5 by 1.
    • y_2025, m_8, d_30, h_9
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_1
    • loc_zh_CN, sid_514145, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getAggregateRating, 103ms
    • REVIEWS, PRODUCT