Date published: 2025-9-7

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Ly-GDI/RhoGDI2/ARHGDIB 抗体 (D-7): sc-271108

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说明书
  • Ly-GDI/RhoGDI2/ARHGDIB抗体(D-7)是小鼠单克隆IgG1 κ, 在5篇文献中引用,规格为200 µg/ml
  • 免疫human物种的代表全长Ly-GDI的氨基酸1-201
  • 推荐用于 mouse, rat 和 human 来源的Ly-GDI WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 Ly-GDI/RhoGDI2/ARHGDIB (G-12): sc-376473,可查看有标记的 Ly-GDI/RhoGDI2/ARHGDIB 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 Ly-GDI/RhoGDI2/ARHGDIB 抗体 (D-7) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Ly-GDI/RhoGDI2/ARHGDIB 抗体 (D-7) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Ras超家族的小GTP结合蛋白是多种细胞信号通路的关键介质,包括导致增殖、细胞骨架组织和分泌的通路。这些蛋白的活性GTP结合形式向其非活性GDP结合形式的反向转化受到两类调节蛋白的影响:一类是改变GTP结合蛋白的内在GTP酶活性,另一类是改变GDP/GTP交换速率。鸟苷酸释放因子(GRFs)增加GDP解离速率,而GDP解离抑制因子(GDIs)降低解离速率。Rho GDI亚家族由Rho GDIα、Ly-GDI(也称为Rho GDIβ,以前称为GDI/D4)和Rho GDIγ组成。Rho GDI蛋白与几种类似Ras的GTP结合蛋白相互作用,包括Rho A、Rho B、Rac和Cdc42,并对它们具有不同的亲和力。Ly-GDI仅在造血细胞中表达,主要在B和T淋巴细胞系中。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Ly-GDI/RhoGDI2/ARHGDIB 抗体 (D-7) 参考文献:

  1. 在Trp53依赖性电离辐射诱导的体外胸腺细胞凋亡过程中,与Rho和Rac分离的裂解LyGDI发生核转位。  |  Zhou, X., et al. 2004. Radiat Res. 162: 287-95. PMID: 15332996
  2. 缺乏N端调节域的RhoGDIβ通过促进v-src转化细胞的凋亡抑制转移。  |  Ota, T., et al. 2006. Clin Exp Metastasis. 23: 323-34. PMID: 17111235
  3. ZAK负调控RhoGDIβ诱导的Rac1介导的肥大生长和细胞迁移。  |  Huang, CY., et al. 2009. J Biomed Sci. 16: 56. PMID: 19538723
  4. RhoGDIβ在中心体的定位及其与癌细胞有丝分裂过程的相关性。  |  Jiang, YS., et al. 2013. Int J Oncol. 42: 460-8. PMID: 23232495
  5. RhoGDIβ抑制骨形态发生蛋白4(BMP4)诱导的脂肪细胞谱系承诺,并促进平滑肌样细胞分化。  |  Huang, HY., et al. 2015. J Biol Chem. 290: 11119-29. PMID: 25778399
  6. 辐射诱导的 RhoGDIβ 分裂导致细胞极性紊乱:癌症扩散的可能联系。  |  Fujiwara, M., et al. 2016. J Cell Physiol. 231: 2493-505. PMID: 26919575
  7. RhoGDIβ通过干扰miR-200c靶向JNK2蛋白的翻译,促进Sp1/MMP-2的表达和膀胱癌的侵袭。  |  Huang, H., et al. 2017. Mol Oncol. 11: 1579-1594. PMID: 28846829
  8. NFκB2 p52通过抑制AUF1蛋白降解来稳定rhogdiβ mRNA,该过程通过miR-145/Sp1/USP8依赖性轴线进行。  |  Xu, J., et al. 2019. Mol Carcinog. 58: 777-793. PMID: 30604907
  9. RhoGDIβ在胰腺β细胞中葡萄糖诱导的Rac1活化和胰岛素分泌的矛盾调节。  |  Thamilselvan, V. and Kowluru, A. 2021. Small GTPases. 12: 114-121. PMID: 31267831
  10. 高血糖应激诱导胰β细胞中Rho GDP解离抑制剂2(RhoGDIβ)的表达、降解和核结合。  |  Gleason, N. and Kowluru, A. 2024. Cells. 13: PMID: 38334664

订购信息

产品名称产品编号规格价格数量收藏夹

Ly-GDI/RhoGDI2/ARHGDIB 抗体 (D-7)

sc-271108
200 µg/ml
RMB2377.00

Ly-GDI/RhoGDI2/ARHGDIB (D-7): m-IgG Fc BP-HRP 套装

sc-540205
200 µg Ab; 10 µg BP
RMB2662.00

Ly-GDI/RhoGDI2/ARHGDIB (D-7): m-IgG1 BP-HRP 套装

sc-541968
200 µg Ab; 20 µg BP
RMB2662.00

Can Ly-GDI (D-7): sc-271108 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: DefinitelyNotMatt
Thank you for your question. Yes, Ly-GDI (D-7): sc-271108 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by from Produced great immunoperoxidase cytoplasmicProduced great immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human cerebellum tissue. -SCBT QC
Date published: 2015-02-15
Rated 5 out of 5 by from Great Western Blot data of LyGreat Western Blot data of Ly-GDI expression in non-transfected 293T, mouse Ly-GDI transfected 293T and U-937 whole cell lysates. -SCBT QC
Date published: 2013-12-01
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Ly-GDI/RhoGDI2/ARHGDIB 抗体 (D-7) is rated 5.0 out of 5 by 2.
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