Date published: 2025-9-8

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LRP130 抗体 (F-7): sc-166178

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说明书
  • LRP130 抗体 F-7 是小鼠单克隆 IgG1 κ,LRP130抗体, 在25篇文献中引用,规格为200 µg/ml
  • 针对氨基酸974-1273的抗原,在LRP130的C-terminus处映射,human来源
  • LRP130 抗体 (F-7) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 LRP130
  • 抗LRP130抗体(F-7)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 可用于凝胶迁移和ChIP的TransCruz试剂(sc-166178 X, 200 µg/0.1 ml)
  • 关于如何获取LRP130 (F-7): sc-166178免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 LRP130 抗体 (F-7) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与LRP130 抗体 (F-7) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

LRP130抗体(F-7)是一种IgG1 κ小鼠单克隆LRP130抗体(也称为LRPPRC抗体、LSFC抗体或GP130抗体),可通过WB、IP、IF、IHC(P)和ELISA检测到小鼠、大鼠和人类来源的LRP130蛋白。LRP130抗体(F-7)既可作为非偶联的抗LRP130抗体形式,也可作为多种偶联形式的抗LRP130抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。富含亮氨酸重复序列(LRR)是一个由20-30个氨基酸组成的基序,它形成一个疏水的α/β马蹄形折叠,使其能够在一个紧密堆积的核心中容纳几个亮氨酸残基。所有的LRR都包含一个可变区段和一个高度保守的区段,后者占整个LRR基序的11或12个残基。富含亮氨酸的蛋白质(LRP130)是一种细胞质mRNA结合蛋白,可能参与线粒体DNA转录本的加工过程。编码LRP130的LRPPRC基因缺陷会导致法国-加拿大型Leigh综合征,这是一种严重的神经系统疾病,其特征是大脑皮层下区域的病变。LRP130还与白血病抑制因子的低亲和力受体相互作用,产生细胞内信号级联反应。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

LRP130 抗体 (F-7) 参考文献:

  1. 作为蛋白质识别图案的富亮氨酸重复序列。  |  Kobe, B. and Kajava, AV. 2001. Curr Opin Struct Biol. 11: 725-32. PMID: 11751054
  2. 对 LRPPRC 及其 SEC1 结构域相互作用伙伴的序列分析表明,它们在细胞骨架组织, 囊泡运输, 核糖体穿梭和染色体活动中发挥作用。  |  Liu, L. and McKeehan, WL. 2002. Genomics. 79: 124-36. PMID: 11827465
  3. LRP130 是一种单链 DNA/RNA 结合蛋白,定域于核外膜和内质网膜,在体内与 mRNA 相互作用。  |  Tsuchiya, N., et al. 2004. Biochem Biophys Res Commun. 317: 736-43. PMID: 15081402
  4. LRPPRC(富亮氨酸五肽重复盒)基因在细胞色素氧化酶组装中的作用:突变导致 COX(细胞色素 c 氧化酶)I 和 COX III mRNA 水平降低。  |  Xu, F., et al. 2004. Biochem J. 382: 331-6. PMID: 15139850
  5. 新的 invMED1 基因顺式激活人类多种药物相关的 MDR1 和 MVP 基因,其中涉及 LRP130 蛋白。  |  Labialle, S., et al. 2004. Nucleic Acids Res. 32: 3864-76. PMID: 15272088
  6. 通过 PGC-1alpha/LRP130 复合物,莱氏综合征法裔加拿大人变异体的能量平衡存在缺陷。  |  Cooper, MP., et al. 2006. Genes Dev. 20: 2996-3009. PMID: 17050673
  7. 靶向 miR-34a/LRPPRC/MDR1 轴可瓦解 P53 非活性结直肠癌的化疗耐药性。  |  Yang, Y., et al. 2022. Cell Death Differ. 29: 2177-2189. PMID: 35484333
  8. RNA结合蛋白LRPPRC能增强肺癌对CDK4/6抑制的抵抗力。  |  Zhou, W., et al. 2023. Nat Commun. 14: 4212. PMID: 37452037
  9. 富含亮氨酸重复序列的蛋白质。  |  Kobe, B. and Deisenhofer, J. 1995. Curr Opin Struct Biol. 5: 409-16. PMID: 7583641
  10. 富含亮氨酸的重复序列:一种多功能的结合图案。  |  Kobe, B. and Deisenhofer, J. 1994. Trends Biochem Sci. 19: 415-21. PMID: 7817399
  11. 人肝母细胞瘤细胞(HepG2)主要富亮氨酸蛋白基因的分子克隆和表达。  |  Hou, J., et al. 1994. In Vitro Cell Dev Biol Anim. 30A: 111-4. PMID: 8012652

订购信息

产品名称产品编号规格价格数量收藏夹

LRP130 抗体 (F-7)

sc-166178
200 µg/ml
RMB2377.00

LRP130 (F-7): m-IgG Fc BP-HRP 套装

sc-528918
200 µg Ab; 10 µg BP
RMB2662.00

LRP130 (F-7): m-IgGκ BP-HRP 套装

sc-521529
200 µg Ab, 40 µg BP
RMB2662.00

LRP130 (F-7): m-IgG1 BP-HRP 套装

sc-543210
200 µg Ab; 20 µg BP
RMB2662.00

LRP130 抗体 (F-7) X

sc-166178 X
200 µg/0.1 ml
RMB2377.00

LRP130 抗体 (F-7) AC

sc-166178 AC
500 µg/ml, 25% agarose
RMB3129.00

LRP130 抗体 (F-7) HRP

sc-166178 HRP
200 µg/ml
RMB2377.00

LRP130 抗体 (F-7) FITC

sc-166178 FITC
200 µg/ml
RMB2482.00

LRP130 抗体 (F-7) PE

sc-166178 PE
200 µg/ml
RMB2580.00

LRP130 抗体 (F-7) Alexa Fluor® 488

sc-166178 AF488
200 µg/ml
RMB2685.00

LRP130 抗体 (F-7) Alexa Fluor® 546

sc-166178 AF546
200 µg/ml
RMB2685.00

LRP130 抗体 (F-7) Alexa Fluor® 594

sc-166178 AF594
200 µg/ml
RMB2685.00

LRP130 抗体 (F-7) Alexa Fluor® 647

sc-166178 AF647
200 µg/ml
RMB2685.00

LRP130 抗体 (F-7) Alexa Fluor® 680

sc-166178 AF680
200 µg/ml
RMB2685.00

LRP130 抗体 (F-7) Alexa Fluor® 790

sc-166178 AF790
200 µg/ml
RMB2685.00

I am curious whether this antibody (sc-166178) is suitable for ICC staining.

Asked by: cy6j
Thank you for your question, Yes this product is suitable for all IHC applications. -Tech Service
Answered by: Tech Service 1
Date published: 2021-01-21

When should the TransCruz reagent sc-166178 X be used instead of the standard form sc-166178?

Asked by: Cweed
Thank you for your question. We recommend using the TransCruz reagent form when performing ChIP or GelShift assays. This form can also be used in other applications such as Western Blot or IHC, but the dilution should be adjusted by a factor of 10 to account for the higher original concentration.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Excellent antibodyThe LRP130 Antibody (F-7): sc-166178 works well for immunofluorescence, showing cytoplasmic localized staining pattern.
Date published: 2017-01-19
Rated 5 out of 5 by from Good antibody for WB and IPThis anti-HA antibody is good for WB at a dilution 1:1000, you can get a very clean and clear bands. And it is also good at IP experiment in 293t cells.
Date published: 2017-01-06
Rated 4 out of 5 by from Positive results in western blot using transfectedPositive results in western blot using transfected lysates. -SCBT QC
Date published: 2015-06-01
Rated 5 out of 5 by from Superb immunofluorescence cytoplasmic stainingSuperb immunofluorescence cytoplasmic staining in formalin-fixed Hep G2 cells. -SCBT QC
Date published: 2015-01-20
Rated 5 out of 5 by from Clean bands in western blot analysis of LRP130Clean bands in western blot analysis of LRP130 expression in HeLa and Hep G2 nuclear extracts, Hep G2 and HeLa whole cell lysates and mouse liver and rat liver tissue extracts. -SCBT QC
Date published: 2015-01-18
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LRP130 抗体 (F-7) is rated 4.8 out of 5 by 5.
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