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LRP1 抗体 (5A6): sc-57351

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  • LRP1 抗体 5A6 是小鼠单克隆 IgG2b,LRP1抗体, 在12篇文献中引用,规格为100 µg/ml
  • 针对全长天然LRP1的抗体,来自human来源
  • 推荐用于 mouse, rat 和 human 来源的85 kDa cleaved fragment of Low Density LRP1 WB (non-reducing), IF, IHC(P) 和 FCM检测
  • m-IgG Fc BP-HRP和 2b BP-HRP">m-IgG2b BP-HRP是LRP1 Antibody (5A6) 适用于 IHC(P) 应用。 的首选辅助检测试剂,这些试剂现与LRP1 Antibody (5A6) 打包提供(请参阅下面的订购信息)。
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LRP1 抗体(5A6)是一种小鼠单克隆 IgG2b 抗体,设计用于检测低密度脂蛋白受体相关蛋白 1(LRP1),也称为 α2-巨球蛋白受体(α2MR)。LRP1 是一种大型、多功能的内细胞受体,其特点是结构复杂,包括富含半胱氨酸的 A 类重复序列、表皮生长因子(EGF)样重复序列、YWTD 重复序列和一个 O 链接糖结构域。这种复杂的结构使 LRP1 能够与各种配体相互作用,促进脂质代谢、蛋白酶清除和细胞信号传导等重要过程。LRP1 的结构完整性对于维持细胞平衡和吸收超过 15 种不同的配体(包括 α2 巨球蛋白和载脂蛋白 E(apolipoprotein E,apoE))至关重要。LRP1 主要在大脑、肝脏和肺部等关键组织的细胞表面表达,突出了其在神经系统健康、代谢调节和呼吸功能方面的重要性。抗 LRP1 抗体 (5A6) 以全长原生人类 LRP1 为靶标,特异性识别小鼠、大鼠和人类等多个物种的 85 kDa 蛋白裂解片段,可用于免疫印迹 (WB)、免疫荧光 (IF)、免疫组织化学 (IHC) 和流式细胞术 (FCM) 等应用。通过对 LRP1 的结构域进行精确分析,LRP1 (5A6) 抗体支持对其在生理过程中的关键作用以及在阿尔茨海默病等病理情况中的参与情况进行深入研究,阿尔茨海默病的 LRP1 基因位于第 12 号染色体上的一个重要位点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

LRP1 抗体 (5A6) 参考文献:

  1. 载脂蛋白E的分子生物学。  |  Strittmatter, WJ. and Bova Hill, C. 2002. Curr Opin Lipidol. 13: 119-23. PMID: 11891413
  2. 载脂蛋白E在神经退行性疾病中的作用。  |  Kolovou, G., et al. 2003. Angiology. 54: 59-71. PMID: 12593497
  3. 载脂蛋白E多态性与动脉粥样硬化。  |  Phillips, MC. 2014. IUBMB Life. 66: 616-23. PMID: 25328986
  4. 载脂蛋白E通过阻断铁蛋白降解来有效抑制铁死亡。  |  Giau, VV., et al. 2015. Neuropsychiatr Dis Treat. 11: 1723-37. PMID: 26213471
  5. GABA能神经元中的LRP1是肥胖和记忆功能之间的关键纽带。  |  Ogaki, K., et al. 2018. Mov Disord. 33: 647-650. PMID: 29442376
  6. 多系统萎缩和载脂蛋白E。  |  Geffin, R. and McCarthy, M. 2018. J Neurovirol. 24: 529-548. PMID: 29987582
  7. 载脂蛋白E同种型与脂蛋白代谢。  |  Nichols, CE., et al. 2021. Am J Respir Cell Mol Biol. 64: 368-378. PMID: 33290178
  8. 成人神经干细胞中LRP1的缺失会妨碍向缺血病灶的迁移。  |  Belaidi, AA., et al. 2024. Mol Psychiatry. 29: 211-220. PMID: 35484240
  9. Lrp1对肺功能的调节。人类GWAS在小鼠中的后续研究。  |  Devignot, S., et al. 2023. Life Sci Alliance. 6: PMID: 37072184
  10. 低密度脂蛋白受体相关蛋白1(LRP1)是RNA病毒的辅助宿主因子。  |  da Cruz Rodrigues, KC., et al. 2024. Mol Metab. 84: 101941. PMID: 38636794

订购信息

产品名称产品编号规格价格数量收藏夹

LRP1 抗体 (5A6)

sc-57351
100 µg/ml
CNY2422.00

LRP1 (5A6): m-IgG Fc BP-HRP 套装

sc-539054
100 µg Ab; 10 µg BP
CNY2715.00

LRP1 (5A6): m-IgG2b BP-HRP 套装

sc-549729
100 µg Ab; 10 µg BP
CNY2715.00

I did IHC on paraffin section of mouse brain and used mouse liver as a positive control a few days ago.I found no signal even on positive control. I did antigen retrival with EDTA and used a dilution of 1:50, incubated in 4 celcieus overnight.

Asked by: eugene02
Thank you for your question. Please reach out to our technical service team so they can offer troubleshooting advice on your experiment.
Answered by: Technical Support Europe
Date published: 2020-10-23

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 8
Date published: 2017-01-09
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Rated 4 out of 5 by dd475 from Tested on HFFF by FACSThis antibody was tested on HFFF cells by FACS and gave a satisfactory signal at dilution 1:25
Date published: 2018-11-16
Rated 5 out of 5 by DefinitelyNotMatt from Reliable Antibody, Great for FlowThis antibody is well-cited for a variety of applications including IP, IF, and even Flow Cytometry. Reliable antibody.
Date published: 2017-01-16
Rated 5 out of 5 by SM from Superb indirect FCM analysis of Hep G2 cellsSuperb indirect FCM analysis of Hep G2 cells stained with LRP1 . -SCBT QC
Date published: 2014-02-15
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LRP1 抗体 (5A6) is rated 4.7 out of 5 by 3.
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