Date published: 2026-10-24

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LOXL2 Antibody (3C5) - Western Blotting - Image 348537
LOXL2 抗体 (3C5): sc-293427. 人重组 LOXL2 融合蛋白的 Western 印迹分析.
LOXL2 Antibody (3C5) - Western Blotting - Image 348537
LOXL2 抗体 (3C5): sc-293427. 人重组 LOXL2 融合蛋白的 Western 印迹分析.
LOXL2 Antibody (3C5) - Western Blotting - Image 366646
LOXL2 抗体 (3C5): sc-293427. SK-MEL-24 (A) 和 NIH/3T3 (B) 全细胞裂解液中 LOXL2 表达的 Western 印迹分析.
LOXL2 抗体 (3C5): sc-293427. 人重组 LOXL2 融合蛋白的 Western 印迹分析.

LOXL2 抗体 (3C5): sc-293427

2.8(4)
寫評論提問
说明书
  • LOXL2 抗体 3C5 是小鼠单克隆 IgG2b κ，LOXL2抗体, 在4篇文献中引用，规格为100 µg/ml
  • 与氨基酸675-773结合，代表human起源的部分长度LOXL2
  • 推荐用于 mouse, rat 和 human 来源的LOXL2 WB, IP 和 ELISA检测
  • 目前，我们还没有完成LOXL2 抗体 (3C5)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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関連項目

额外LOXL抗体，包括LOXL1, LOXL2, LOXL3和LOXL4

LOXL2抗体（3C5）是一种小鼠单克隆IgG2b kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和酶联免疫吸附测定（ELISA）检测小鼠、大鼠和人类来源的LOXL2蛋白。抗LOXL2抗体（3C5）以非结合形式提供。赖氨酰氧化酶（LOX）家族中的酶（包括LOXL2）在修饰细胞外基质成分方面发挥着关键作用，特别是在胶原蛋白和弹性蛋白中形成交联。这种交联作用可保持组织的结构完整性和弹性，对于器官的正常功能和组织修复至关重要。LOXL2定位于弹性蛋白生成部位，作为一种交联酶，促进弹性蛋白沉积，并与纤连蛋白-5相互作用，调节弹性蛋白的组装。LOXL2与多种细胞过程有关，包括肿瘤抑制和上皮-间质转化，这是癌症进展的关键事件。LOXL2与Snail蛋白相互作用会导致E-cadherin下调，从而促进上皮细胞的侵袭性。研究表明，LOXL2的敲除可显著减少肿瘤生长，这凸显了LOXL2作为癌症治疗靶标的潜力。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

LOXL2 抗体 (3C5) 参考文献:

  1. LOXL2 基因编码一种新的赖氨酰氧化酶样蛋白，在生殖组织中高水平表达。  |  Jourdan-Le Saux, C., et al. 1999. J Biol Chem. 274: 12939-44. PMID: 10212285
  2. 赖氨酰氧化酶：一个新型多功能胺氧化醇类。  |  Csiszar, K. 2001. Prog Nucleic Acid Res Mol Biol. 70: 1-32. PMID: 11642359
  3. 赖氨酰氧化酶在乳腺癌侵袭中的分子作用。  |  Kirschmann, DA., et al. 2002. Cancer Res. 62: 4478-83. PMID: 12154058
  4. 赖氨酰氧化酶和 LOX 类似蛋白的结构和功能多样性。  |  Molnar, J., et al. 2003. Biochim Biophys Acta. 1647: 220-4. PMID: 12686136
  5. 赖氨酰氧化酶同工酶在 MC3T3-E1 成骨细胞中的表达。  |  Atsawasuwan, P., et al. 2005. Biochem Biophys Res Commun. 327: 1042-6. PMID: 15652501
  6. 威尔逊氏病肝细胞周围胶原蛋白的异常沉积与肝细胞特异性表达赖氨酰氧化酶和赖氨酰氧化酶样蛋白-2有关。  |  Vadasz, Z., et al. 2005. J Hepatol. 43: 499-507. PMID: 16023247
  7. 赖氨酰氧化酶样 2 酶在蜗牛调节和肿瘤进展中的分子作用。  |  Peinado, H., et al. 2005. EMBO J. 24: 3446-58. PMID: 16096638
  8. 将 LOXL2 与心脏间质纤维化联系起来。  |  Erasmus, M., et al. 2020. Int J Mol Sci. 21: PMID: 32824630
  9. 癌症中的 LOXL2：调控、下游效应因子和新作用。  |  Wen, B., et al. 2020. Biochim Biophys Acta Rev Cancer. 1874: 188435. PMID: 32976981
  10. LOXL2抑制剂与乳腺癌进展。  |  Ferreira, S., et al. 2021. Antioxidants (Basel). 10: PMID: 33669630
  11. LOXL2 在肝细胞癌进展中的多重作用及其靶向治疗的潜力。  |  Radić, J., et al. 2023. Int J Mol Sci. 24: PMID: 37511503
  12. 抑制 LOXL2 可改善肺动脉高压的肺动脉重塑  |  Steppan, J., et al. 2023. bioRxiv.. PMID: 37961202

订购信息

产品名称产品编号规格价格数量收藏夹

LOXL2 抗体 (3C5)

sc-293427
100 µg/ml
CNY2422.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with LOXL2 (3C5): sc-293427 antibody?

Asked by: Germaine
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by SCBT QC Lab from Good for Western BlotThis antibody detects bands at the expected molecular weight in SK-MEL-24 and NIH/3T3 whole cell lysates. -SCBT QC
Date published: 2023-09-14
Rated 3 out of 5 by Anastasia_DL from Aspecific BandsI have used this Ab for Western Blot,1:1000, on MDA-MB-231 cells extracts. The signal is not well defined because there are a lot of specific bands although it is possible to clearly identified the protein of interest (LOXL2).
Date published: 2019-11-27
Rated 2 out of 5 by sbalig2 from Fair featuresBlocked in 5% BSA-TBST 1:500. Incubated in primary overnight in cold room. Tested on Murine Fallopian Tube Tissue and Human Ovarian Cell Lines.Worked in both but worked better on human cell lines and there are a lot of non-specific bands.
Date published: 2017-07-24
Rated 1 out of 5 by dchan from No signal on western blotsTested this antibody twice in western blots with various tumor samples that vary from none to high levels of LOXL2 as determined by mass spectrometry; no signal detected in western blot when used in conjunction with SCBT Kappa-binding-HRP as secondary.
Date published: 2016-11-10
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LOXL2 抗体 (3C5) is rated 2.8 out of 5 by 4.
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