Date published: 2025-9-7

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LI-cadherin 抗体 (B-1): sc-393045

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说明书
  • LI-cadherin抗体(B-1)是小鼠单克隆IgG2b (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于human物种的LI-cadherin的C-terminus的氨基酸806-832之间
  • 推荐用于 human 来源的LI-cadherin WB, IP, IF, IHC(P) 和 ELISA检测; 也和以下物种反应,包括: equine
  • m-IgG2b BP-HRPm-IgGκ BP-HRP 是 LI-cadherin 抗体 (B-1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与LI-cadherin 抗体 (B-1) 组合成套装提供。 (请参阅下面的订购信息)。

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    関連項目

    钙粘蛋白是一类依赖于钙离子的粘附分子家族,它们的功能是介导细胞-细胞之间的结合,这种结合对于维持组织结构和形态发生至关重要。每种钙粘蛋白在其氨基末端都含有一个大的细胞外结构域,该结构域的特点是由五个同源重复序列组成,其中最远端的一个被认为负责结合特异性。相对较短的羧基末端,即胞内结构域,与多种胞质蛋白(包括连环蛋白β)相互作用,以调节钙粘蛋白的功能。LI-cadherin(代表肝-肠钙粘蛋白)的表达仅限于肝和肠组织,并且特异性地定位于肝细胞和肠细胞的基底外侧结构域。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    LI-cadherin 抗体 (B-1) 参考文献:

    1. 胃癌中LI-cadherin的过度表达与转移淋巴结有关。  |  Ko, S., et al. 2004. Biochem Biophys Res Commun. 319: 562-8. PMID: 15178443
    2. 胃癌和肠上皮化生中Li-cadherin的表达改变。  |  Dong, W., et al. 2007. Dig Dis Sci. 52: 536-42. PMID: 17226075
    3. Li-cadherin与胃癌中galectin-3的表达呈负相关。  |  Dong, WG., et al. 2008. Dig Dis Sci. 53: 1811-7. PMID: 17999183
    4. 敲除Li-cadherin会增加LoVo细胞的转移行为。  |  Yu, QF., et al. 2010. J Cancer Res Clin Oncol. 136: 1641-9. PMID: 20204409
    5. LI-cadherin在细胞质膜中顺式二聚化Ca(2+)独立且形成高度动态的跨接触。  |  Bartolmäs, T., et al. 2012. Cell Mol Life Sci. 69: 3851-62. PMID: 22842778
    6. 敲除LI-cadherin可改变基质金属蛋白酶-2, -9和galectin-3的表达。  |  Yu, Q., et al. 2016. Mol Med Rep. 13: 4469-74. PMID: 27035870
    7. 在不同渗透条件下,水通过肠上皮屏障的运输取决于LI-cadherin的跨相互作用。  |  Weth, A., et al. 2017. Tissue Barriers. 5: e1285390. PMID: 28452574
    8. LI-cadherin和CDX2:浆液性腔积液中转移性胃肠道腺癌细胞的有用标记物。  |  Ma, H., et al. 2019. Appl Immunohistochem Mol Morphol. 27: e75-e80. PMID: 30095466
    9. 人类LI-cadherin的二聚化机制和结构特征。  |  Yui, A., et al. 2021. J Biol Chem. 297: 101054. PMID: 34364873
    10. LI-cadherin基因单核苷酸多态性导致结直肠癌转移风险增加的分子机制。  |  Yui, A., et al. 2023. Sci Rep. 13: 6493. PMID: 37081068

    订购信息

    产品名称产品编号规格价格数量收藏夹

    LI-cadherin 抗体 (B-1)

    sc-393045
    200 µg/ml
    RMB2377.00

    LI-cadherin (B-1): m-IgGκ BP-HRP 套装

    sc-535681
    200 µg Ab; 40 µg BP
    RMB2662.00

    LI-cadherin (B-1): m-IgG2b BP-HRP 套装

    sc-549470
    200 µg Ab; 10 µg BP
    RMB2662.00

    LI-cadherin (B-1) 中和勝肽

    sc-393045 P
    100 µg/0.5 ml
    RMB511.00

    Buenas, voy a comprar varios anticuerpos y me gustaría saber si podría solicitar 10ug de muestra gratuita de este anticuerpo :LI-cadherin Anticuerpo (B-1): sc-393045

    Asked by: Laura243
    Thank you for your question. Please contact Technical Service or your local distributor for information on how to receive a free 10 ug sample of this monoclonal antibody.
    Answered by: Tech Service
    Date published: 2019-10-03

    What application is the blocking peptide sc-393045 P appropriate for?

    Asked by: jenniferc
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-03-01
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    Rated 4 out of 5 by from Immunoperoxidase staining of formalin fixedImmunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing membrane and cytoplasmic staining of glandular cells. -SCBT QC
    Date published: 2015-04-03
    Rated 4 out of 5 by from Western blot signal of LIWestern blot signal of LI-cadherin expression in human colon tissue extract. -SCBT QC
    Date published: 2013-03-01
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    LI-cadherin 抗体 (B-1) is rated 4.0 out of 5 by 2.
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