LFM-A13 (CAS 62004-35-7)

物理状态 :

Solid

溶解度 :

Soluble in ethanol (50 mM), 1eq. NaOH (5 mM), DMSO (~10 mg/ml), 1:2 DMF:PBS (pH 7.2) (~0.3 mg/ml), and DMF (~20 mg/ml).

保存 :

Store at room temperature

熔点 :

146° C

沸点 :

487.90° C at 760 mmHg (Predicted)

密度 :

1.91 g/cm³ (Predicted)

折射率 :

n²⁰_D 1.68 (Predicted)

IC50 :

recombinant BTK: IC₅₀ = 2.5 µM; Serine/threonine-protein kinase PLK1: IC₅₀ = 10.3 µM (Xenopus laevis); BTK in vitro: IC₅₀ = 17.2 µM (human); Serine/threonine-protein kinase PLK3: IC₅₀ = 7.2 µM (human)

Ki 数据 :

Escherichia coli DdlB: K_i= 185 µM

pK值 :

pK_a: 5.20

德国水公害等级 :

3

PubChem CID :

MDL 号码 :

MFCD09878279

SMILES :

CC(=O)/C(=C(/NC1=C(C=CC(=C1)Br)Br)\\O)/C#N