Date published: 2025-9-7
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Laminin-R Antibody (16) - Western Blotting - Image 39096
层粘蛋白-R 抗体 (16): sc-101517. 293T (A) 和 HeLa (B) 全细胞裂解液中 Laminin-R 表达的 Western 印迹分析.
层粘蛋白-R 抗体 (16): sc-101517. 293T (A) 和 HeLa (B) 全细胞裂解液中 Laminin-R 表达的 Western 印迹分析.

Laminin-R 抗体 (16): sc-101517

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说明书
  • Laminin-R抗体(16)是小鼠单克隆IgG2a κ, 在3篇文献中引用，规格为200 µg/ml
  • 免疫human物种的重组Laminin-R
  • 推荐用于 human 来源的Laminin-R WB, IP 和 ELISA检测
  • 看 Laminin-R (H-2): sc-74515，可查看有标记的 Laminin-R 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 2a BP-HRP">m-IgG2a BP-HRP是Laminin-R Antibody (16) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Laminin-R Antibody (16) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

层粘连蛋白受体（Laminin-R）具有与纤维连接蛋白和玻连蛋白等其他细胞外基质蛋白受体相似的异二聚体结构。层粘连蛋白-R结合到溶酶体膜上，使溶酶体能够附着在涂有层粘连蛋白的表面。这种和其他特性将层粘连蛋白-R鉴定为细胞粘附受体整联蛋白家族的成员。层粘连蛋白R前体是一种多肽，在侵袭性癌中的表达始终上调。前体也被鉴定为p40核糖体相关蛋白，似乎是一种参与翻译机制的多功能蛋白。层粘连蛋白-R（也称为结肠癌层粘连蛋白结合蛋白），在结肠癌中的含量是邻近正常结肠上皮的9倍。此外，肺癌症细胞系中的层粘连蛋白-R水平高于肺细胞系。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Laminin-R 抗体 (16) 参考文献:

  1. LAMA1基因启动子区域中的单核苷酸多态性与中国高度近视的易感性有关。  |  Zhao, YY., et al. 2011. Mol Vis. 17: 1003-10. PMID: 21541277
  2. MicroRNA-202抑制食管鳞状细胞癌中LAMA1的肿瘤进展。  |  Meng, X., et al. 2016. Biochem Biophys Res Commun. 473: 821-827. PMID: 27045085
  3. dCas9-VP160可增加层粘连蛋白亚基α1链的表达。  |  Perrin, A., et al. 2017. Mol Ther Nucleic Acids. 6: 68-79. PMID: 28325301
  4. 高度近视儿童中的TGFB1和LAMA1基因多态性。  |  Biler, ED., et al. 2018. Pak J Med Sci. 34: 463-467. PMID: 29805427
  5. 发现了LAMA1变异型 茹贝尔综合征患者。  |  Noguchi, Y., et al. 2022. Pediatr Int. 64: e14980. PMID: 35224822
  6. LAMA1新突变引起的视网膜病变变异。  |  Schiff, ER., et al. 2022. Ophthalmic Genet. 43: 671-678. PMID: 35616092
  7. 实验性青光眼对Lama1nmf223突变小鼠的影响。  |  Madhoun, S., et al. 2023. Exp Eye Res. 226: 109341. PMID: 36476399
  8. LAMA1单核苷酸多态性与中国东部人群食管鳞状细胞癌风险的关系。  |  Zhang, S., et al. 2023. J Oncol. 2023: 6922909. PMID: 36824663
  9. CRISPRa诱导的人LAMA1上调可弥补Merosin缺乏性先天性肌营养不良症中LAMA2的缺陷。  |  Arockiaraj, AI., et al. 2023. bioRxiv.. PMID: 36945402
  10. Lama1上调延长了dyH/dyH小鼠模型的寿命，该模型与LAMA2相关的先天性肌肉萎缩症。  |  Liu, Y., et al. 2024. J Genet Genomics. 51: 1066-1078. PMID: 38777118

订购信息

产品名称产品编号规格价格数量收藏夹

Laminin-R 抗体 (16)

sc-101517
200 µg/ml
RMB2377.00

Laminin-R (16): m-IgG Fc BP-HRP 套装

sc-539773
200 µg Ab; 10 µg BP
RMB2662.00

Laminin-R (16): m-IgG2a BP-HRP 套装

sc-546782
200 µg Ab; 10 µg BP
RMB2662.00

Dear SC Team, I would like to use this antibody to detect by ELISA the 37KDa isoform only, do you know whether your antibody cross reacts with the 67KDa? could you confirm that your antibody is specific for the 37KDa only?Thanks

Asked by: Fede CB
Thank you for your question. We have not observed a 67 kDa band when testing this antibody, Laminin-R Antibody (16): sc-101517, in Western blot. However, we have not specifically tested whether or not this antibody has an epitope that may also cross-react with the 67 kDa isoform. And the exact epitope recognized by this monoclonal antibody has not been determined.
Answered by: Technical Support
Date published: 2017-07-20

What is the recommended starting dilution for Western blot for Laminin-R (16): sc-101517 monoclonal antibody?

Asked by: Trav11
Thank you for your question. The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, can be found in the “datasheet” link at the top of the product page, for which I have provided the link: https://datasheets.scbt.com/sc-101517.pdf If you have any further questions or concerns, please contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Technical Support
Date published: 2017-07-20
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Rated 4 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB. -SCBT QC
Date published: 2015-07-04
Rated 4 out of 5 by from Band seen in WB using HeLa whole cell lysateBand seen in WB using HeLa whole cell lysate. -SCBT QC
Date published: 2015-03-06
Rated 4 out of 5 by from Publishable data in WB using human bloodPublishable data in WB using human blood. -SCBT Publication Review
Date published: 2014-10-04
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Laminin-R 抗体 (16) is rated 4.0 out of 5 by 3.
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