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L-Plastin Antibody (C-4) - Western Blotting - Image 356747
L-Plastin 抗体 (C-4): sc-133219. HL-60 (A), Ramos (B), Raji (C), Jurkat (D) 和 CCRF-CEM (E) 全细胞裂解液中 L-Plastin 表达的 Western 印迹分析.
L-Plastin 抗体 (C-4): sc-133219. HL-60 (A), Ramos (B), Raji (C), Jurkat (D) 和 CCRF-CEM (E) 全细胞裂解液中 L-Plastin 表达的 Western 印迹分析.

L-Plastin 抗体 (C-4): sc-133219

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寫評論提問

说明书
  • L-Plastin抗体(C-4)是小鼠单克隆IgG1 κ, 在2篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的L-Plastin的内部区域内的氨基酸298-331之间
  • 推荐用于 mouse, rat 和 human 来源的L-Plastin WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 L-Plastin 抗体 (C-4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与L-Plastin 抗体 (C-4) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Plastin 抗体包括 L-Plastin 和 T-Plastin

Plastins（也称为fimbrins）是一类肌动蛋白结合蛋白的家族成员，它们表现出组织特异性表达模式。L-Plastin和T-Plastin都被证明参与细胞骨架的重组。L-Plastin特异性表达于造血细胞系中，被认为参与细胞粘附和运动的控制。它经常在来源于乳腺实体瘤的细胞系中表达，并与癌症的侵袭和转移有关。L-Plastin也在大多数来源于各种实体瘤的人类癌细胞系中表达。此外，L-Plastin还参与白细胞粘附的调节，L-Plastin的磷酸化与整合素调节信号通路的调制有关。T-Plastin的独特之处在于它在多种类型的组织中表达，而在白细胞中则明显缺失。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

L-Plastin 抗体 (C-4) 参考文献:

  1. L-弹性蛋白调节趋化因子刺激的人类 T 淋巴细胞的极化和迁移。  |  Freeley, M., et al. 2012. J Immunol. 188: 6357-70. PMID: 22581862
  2. 肌动蛋白结合蛋白L-plastin：一种与牙周炎相关的新的局部炎症标志物。  |  Öztürk, VÖ., et al. 2015. J Periodontal Res. 50: 337-46. PMID: 25040533
  3. 乳腺癌细胞和体外培养的L-plastin Ser5磷酸化由ERK/MAPK途径下游的RSK介导。  |  Lommel, MJ., et al. 2016. FASEB J. 30: 1218-33. PMID: 26631483
  4. L-Plastin可延长足突寿命，支持巨噬细胞运动。  |  Zhou, JY., et al. 2016. Mol Immunol. 78: 79-88. PMID: 27614263
  5. 乳腺癌细胞外泌体释放 L-Plastin 促进转移性骨质溶解  |  Tiedemann, K., et al. 2019. Transl Oncol. 12: 462-474. PMID: 30583289
  6. 外泌体 L-Plastin 减少是辐射诱导的旁观者效应的原因。  |  Freudenmann, LK., et al. 2019. Exp Cell Res. 383: 111498. PMID: 31302031
  7. L-Plastin缺乏导致骨小梁增多，这是由于密封环形成减弱和破骨细胞功能障碍所致。  |  Chellaiah, MA., et al. 2020. Bone Res. 8: 3. PMID: 31993243
  8. 肌动蛋白结合蛋白L-plastin-A是一把双刃剑：对免疫反应有益，对癌症有害。  |  Schaffner-Reckinger, E. and Machado, RAC. 2020. Int Rev Cell Mol Biol. 355: 109-154. PMID: 32859369
  9. 将肌动蛋白结合蛋白 L-弹性蛋白作为治疗骨质流失的同化疗法的靶点。  |  Li, X., et al. 2020. Sci Adv. 6: PMID: 33208358
  10. L-plastin相关免疫缺陷和血液细胞减少综合征。  |  Hernandez, RA., et al. 2024. J Allergy Clin Immunol. 154: 767-777. PMID: 38710235

订购信息

产品名称产品编号规格价格数量收藏夹

L-Plastin 抗体 (C-4)

sc-133219
200 µg/ml
RMB2377.00

L-Plastin (C-4): m-IgG Fc BP-HRP 套装

sc-537358
200 µg Ab; 10 µg BP
RMB2662.00

L-Plastin (C-4): m-IgGκ BP-HRP 套装

sc-534603
200 µg Ab; 40 µg BP
RMB2662.00

L-Plastin (C-4): m-IgG1 BP-HRP 套装

sc-545155
200 µg Ab; 20 µg BP
RMB2662.00

L-Plastin (C-4) 中和勝肽

sc-133219 P
100 µg/0.5 ml
RMB511.00

What is the difference between C-4 and B-9 l-plastin antibodies? different parts of the protein?  thank you

Asked by: MJY1
Thank you for your question. These antibodies are produced by different clones. Both of them were raised against amino acid range 298-331 of human Plastin, but target different sequences within that region. Due to this they will also exhibit slight differences in their binding properties, but will generally perform quite similarly.
Answered by: Tech Support Europe
Date published: 2022-03-25

What application is the blocking peptide sc-133219 P appropriate for?

Asked by: jenniferc
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from Produced great immunoperoxidase cytoplasmicProduced great immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human spleen tissue. -SCBT QC
Date published: 2015-05-10
Rated 5 out of 5 by from Good publishable data in IHC in human normalGood publishable data in IHC in human normal colorectal tissues. -SCBT Publication Review
Date published: 2015-02-24
Rated 5 out of 5 by from Strong band in WB in human transfected 293TStrong band in WB in human transfected 293T and CCRF-CEM, K-562 and RAW 264.7 whole cell lysates. -SCBT QC
Date published: 2015-01-20
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L-Plastin 抗体 (C-4) is rated 5.0 out of 5 by 3.
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