Date published: 2026-9-9

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KLK10 Antibody (I-06) - Western Blotting - Image 33924
KLK10 抗体 (I-06): sc-100551. Western 印迹分析 A-431 全细胞裂解液中 KLK10 的表达.
KLK10 Antibody (I-06) - Western Blotting - Image 33924
KLK10 抗体 (I-06): sc-100551. Western 印迹分析 A-431 全细胞裂解液中 KLK10 的表达.
KLK10 Antibody (I-06) - Immunofluorescence - Image 35594
KLK10 抗体 (I-06): sc-100551. 免疫荧光染色多聚甲醛固定的 A-431 细胞, 显示细胞质定位.
KLK10 抗体 (I-06): sc-100551. Western 印迹分析 A-431 全细胞裂解液中 KLK10 的表达.

KLK10 抗体 (I-06): sc-100551

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寫評論提問

说明书
  • KLK10抗体(I-06)是小鼠单克隆IgG1 λ KLK10抗体, 在4篇文献中引用，规格为50 µg/0.5 ml
  • 免疫human物种的重组KLK10
  • 推荐用于 human 来源的KLK10 WB, IP, IF 和 ELISA检测
  • 目前，我们还没有完成KLK10 抗体 (I-06)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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関連項目

额外KLK抗体，包括KLK1, KLK10, KLK11, KLK15, KLK4和KLK7

KLK10抗体（I-06）是一种IgG1 λ小鼠单克隆KLK10抗体（也被称为KLK10抗体），它可以通过WB、IP、IF和ELISA检测人体来源的KLK10蛋白。KLK10抗体（I-06）为非偶联型抗KLK10抗体。激肽释放酶（KLKs）属于丝氨酸蛋白酶类的蛋白水解酶。人体胰/肾KLK编码KLK1酶，参与多肽前体的翻译后加工。KLK基因家族中其他成员的功能目前尚不清楚，但有证据表明，许多KLKs与致癌作用有关。人类KLK基因家族由15个丝氨酸蛋白酶组成。人类KLK基因聚集在19q13染色体上。与其他激肽释放酶不同，KLK4-15编码的蛋白酶相关性较小，且不含有常规的KLK环。基因簇表现出较高的前列腺（KLK2-4，KLK15）或胰腺（KLK6-13）表达。KLK2也被称为腺激肽释放酶2、组织激肽释放酶或HGK-1，KLK3被称为前列腺特异性抗原（PSA）。KLK2和KLK3在前列腺癌和乳腺癌的诊断中都有重要的应用。KLK4、KLK5、KLK9、KLK13、KLK12和KLK14之前分别被称为KLK-L1、KLK-L2、KLK-L3、KLK-L4、KLK-L5和KLK-L6。许多KLKs受类固醇激素的调节，其中少数，特别是KLK3、KLK6和KLK10，在乳腺癌和其他癌症中已知被下调。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

KLK10 抗体 (I-06) 参考文献:

  1. 新的人类 kallikrein 基因家族：对致癌的影响。  |  Diamandis, EP., et al. 2000. Trends Endocrinol Metab. 11: 54-60. PMID: 10675891
  2. 染色体 19q13.3-q13.4 上人类 kallikrein 基因家族的基因组组织。  |  Yousef, GM., et al. 2000. Biochem Biophys Res Commun. 276: 125-33. PMID: 11006094
  3. 人类 Kallikrein 15 基因（KLK15）的分子克隆。前列腺癌中的上调。  |  Yousef, GM., et al. 2001. J Biol Chem. 276: 53-61. PMID: 11010966
  4. 扩展的人类 Kallikrein（KLK）基因家族：基因组组织, 组织特异性表达和潜在功能。  |  Clements, J., et al. 2001. Biol Chem. 382: 5-14. PMID: 11258672
  5. 克隆在不同恶性肿瘤中下调的人类 Kallikrein 基因家族新成员 KLK14。  |  Yousef, GM., et al. 2001. Cancer Res. 61: 3425-31. PMID: 11309303
  6. 正常大脑和阿尔茨海默氏症大脑中凯利克林基因家族的表达。  |  Shimizu-Okabe, C., et al. 2001. Neuroreport. 12: 2747-51. PMID: 11522960
  7. NES1/KLK10通过激活PI3K/AKT信号通路促进胃癌对曲妥珠单抗的耐药性  |  Tang, L., et al. 2018. J Cell Biochem. 119: 6398-6407. PMID: 29231994
  8. Kallikrein10（KLK10）多态性在前列腺癌易感性中的作用  |  Güleç Yılmaz, S., et al. 2021. Urol J. 19: 41-44. PMID: 34089177
  9. 稳定流动诱导的 KLK10 表达可抑制内皮炎症和动脉粥样硬化。  |  Williams, D., et al. 2022. Elife. 11: PMID: 35014606
  10. KLK10通过PAR1-PDK1-AKT信号通路促进KRAS突变型结直肠癌的进展。  |  Wu, K., et al. 2024. Cell Biol Int. 48: 440-449. PMID: 38115179
  11. KLK10/LIPH/PARD6B/SLC52A3是通过ceRNA网络预测胰腺癌预后的有希望的分子生物标记物。  |  Zhang, M., et al. 2024. Heliyon. 10: e24287. PMID: 38234923
  12. 源自肿瘤内皮细胞的 KLK10 可加速结肠癌细胞增殖和血源性肝转移的形成。  |  Kato, K., et al. 2024. Cancer Sci. 115: 1520-1535. PMID: 38475666

订购信息

产品名称产品编号规格价格数量收藏夹

KLK10 抗体 (I-06)

sc-100551
50 µg/0.5 ml
CNY2550.00

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with KLK10 (I-06): sc-100551 monoclonal antibody?

Asked by: Germaine
We recommend using one of our our exclusive Mouse IgG Binding Proteins (m-IgGλ) conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Good Overall PerformanceThis anti-KLK10 antibody showed acceptable and reproducible performance in our experiments. The results were consistent after optimization, and the antibody was suitable for detecting KLK10 in our cell samples. Overall, it represented a good option for our research
Date published: 2026-08-07
Rated 5 out of 5 by from Good for Western BlotThis antibody has been used for western blot in published research. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from Produced exceptional immunofluorescence cytoplasmicProduced exceptional immunofluorescence cytoplasmic staining in paraformaldehyde-fixed A-431 cells. -SCBT QC
Date published: 2015-04-20
Rated 5 out of 5 by from Robust signal in WB in ARobust signal in WB in A-431 whole cell lysate. -SCBT QC
Date published: 2015-01-10
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KLK10 抗体 (I-06) is rated 4.8 out of 5 by 4.
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