Date published: 2025-9-8
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KCNQ2 Antibody (F-3) - Western Blotting - Image 137801
KCNQ2 抗体 (F-3): sc-365115. CCD-1064Sk 全细胞裂解液中 KCNQ2 表达的 Western 印迹分析.
KCNQ2 Antibody (F-3) - Western Blotting - Image 137801
KCNQ2 抗体 (F-3): sc-365115. CCD-1064Sk 全细胞裂解液中 KCNQ2 表达的 Western 印迹分析.
KCNQ2 Antibody (F-3) - Immunofluorescence - Image 142821
KCNQ2 抗体 (F-3): sc-365115. 甲醇固定的 HeLa 细胞免疫荧光染色, 显示胞质定位.
KCNQ2 Antibody (F-3) - Western Blotting - Image 393061
KCNQ2 抗体 (F-3): sc-365115. Western 印迹分析 SK-MEL-28 全细胞裂解液中 KCNQ2 的表达.
KCNQ2 抗体 (F-3): sc-365115. CCD-1064Sk 全细胞裂解液中 KCNQ2 表达的 Western 印迹分析.

KCNQ2 抗体 (F-3): sc-365115

3.5(4)
寫評論提問

说明书
  • KCNQ2抗体(F-3)是小鼠单克隆IgG1 κ, 在2篇文献中引用，规格为200 µg/ml
  • 免疫原氨基酸序列641-780位于human物种的KCNQ2的C-terminus附近
  • 推荐用于 human 来源的KCNQ2 WB, IP, IF 和 ELISA检测
  • m-IgGκ BP-HRP是KCNQ2 Antibody (F-3) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与KCNQ2 Antibody (F-3) 搭配使用（请参阅下面的订购信息）。有关其它 m-IgGκ BP 结合物，请参阅我们完整的小鼠 IgG 结合蛋白列表。

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相关产品
描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

此外 KCNQ 抗体包括 和

癫痫影响着世界上约0.5%的人口，并且具有很大的遗传成分。癫痫是由中枢神经系统的电过度兴奋引起的。钾通道是电信号的重要调节因子，决定着各种神经元的放电特性和反应性。良性家族性新生儿惊厥（BFNC）是一种婴儿期常染色体显性遗传癫痫，已被证明是由KCNQ2或KCNQ3钾通道基因突变引起的。KCNQ2和KCNQ3是电压门控钾通道蛋白，具有六个假定的跨膜结构域。这两种蛋白质在大脑内分布广泛，表达模式在很大程度上重叠。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

KCNQ2 抗体 (F-3) 参考文献:

  1. FGF14是KCNQ2/3通道的调节因子。  |  Pablo, JL. and Pitt, GS. 2017. Proc Natl Acad Sci U S A. 114: 154-159. PMID: 27994149
  2. 癫痫相关的KCNQ2通道调节2/3层锥体神经元的多种内在特性。  |  Niday, Z., et al. 2017. J Neurosci. 37: 576-586. PMID: 28100740
  3. 婴儿早期KCNQ2癫痫性脑病。  |  Kasinathan, A., et al. 2017. Indian J Pediatr. 84: 877-878. PMID: 28631195
  4. KCNQ2相关癫痫的抗癫痫治疗：系统综述。  |  Kuersten, M., et al. 2020. Eur J Med Genet. 63: 103628. PMID: 30771507
  5. 导致良性新生儿癫痫或发育性癫痫性脑病的KCNQ2变体的特征。  |  Goto, A., et al. 2019. Epilepsia. 60: 1870-1880. PMID: 31418850
  6. KCNQ2 R144变体通过功能增强机制导致神经发育障碍，伴有语言障碍和自闭症特征，但不伴有新生儿癫痫发作。  |  Miceli, F., et al. 2022. EBioMedicine. 81: 104130. PMID: 35780567
  7. 癫痫性脑病相关KCNQ2孔突变的功能表征和体外药理学修复。  |  Yang, GM., et al. 2023. Acta Pharmacol Sin. 44: 1589-1599. PMID: 36932231
  8. KCNQ2相关性癫痫的癫痫活动与发育结果之间的关系。  |  Casas-Alba, D., et al. 2023. Pediatr Neurol. 144: 11-15. PMID: 37099824
  9. KCNQ2通道调节新生儿GABA能神经元的体外群体活性。  |  Hou, B., et al. 2023. Front Neurol. 14: 1207539. PMID: 37409016
  10. 多奈哌齐在KCNQ2和KCNQ3相关自闭症中的新治疗潜力。  |  Nissenkorn, A., et al. 2024. Front Cell Neurosci. 18: 1380442. PMID: 39175503

订购信息

产品名称产品编号规格价格数量收藏夹

KCNQ2 抗体 (F-3)

sc-365115
200 µg/ml
RMB2377.00

KCNQ2 (F-3): m-IgGκ BP-HRP 套装

sc-535152
200 µg Ab; 40 µg BP
RMB2662.00

What does the F-3 at the end of the name indicate? You have others (E6 and C4) for the same KCNQ2 antibody, what are they indicative of?

Asked by: Simple question
Thank you for your question .The letters and numbers in parenthesis are the clone number .That is how we identify the antibody in- house.
Answered by: BlakeJ
Date published: 2022-11-22

What is the recommended fixation method for immunofluorescence staining with KCNQ2 (F-3): sc-365115 monoclonal antibody?

Asked by: Randy McDonald
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-02-25
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Rated 3 out of 5 by from Decent bands on western blotDecent bands on western blot, CHO cells or native tissue.
Date published: 2015-10-12
Rated 5 out of 5 by from Good fluorescence in IF with methanolGood fluorescence in IF with methanol-fixed HeLa cells -SCBT QC
Date published: 2015-04-30
Rated 1 out of 5 by from Did not work in tissue after methanol fixationDid not work in tissue after methanol fixation
Date published: 2015-04-30
Rated 5 out of 5 by from StrongStrong, single band in WB with CCD-1064Sk whole cell lysate. -SCBT QC
Date published: 2015-01-28
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KCNQ2 抗体 (F-3) is rated 3.5 out of 5 by 4.
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