Date published: 2025-9-7

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JMJD2A 抗体 (H-8): sc-373850

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说明书
  • JMJD2A抗体(H-8)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 免疫原氨基酸序列347-633位于human物种的JMJD2A的内部区域内
  • 推荐用于 mouse, rat 和 human 来源的JMJD2A WB, IP, IF 和 ELISA检测
  • m-IgGκ BP-HRP是JMJD2A Antibody (H-8) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与JMJD2A Antibody (H-8) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGκ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。

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    関連項目

    JMJD2A(含有jumonji结构域的2A),也被称为含有jumonji C结构域的组蛋白去甲基化蛋白3A,是由人类基因JMJD2A编码的包含1064个氨基酸的蛋白质。JMJD2A属于JHDM3组蛋白去甲基酶家族,并含有一个JmjC结构域、一个JmjN结构域、两个PHD型锌指和两个Tudor结构域。JMJD2A是组蛋白去甲基酶,能特异性地去甲基化组蛋白H3的Lys 9和Lys 36残基,从而在组蛋白编码中起核心作用。然而,它并不去甲基化组蛋白H3 Lys 4、H3 Lys 27或H4 Lys 20,而是去甲基化三甲基化的H3 Lys 9和H3 Lys 36残基,对单甲基化和二甲基化残基则无活性。JMJD2A对赖氨酸残基的去甲基化会产生甲醛和琥珀酸盐。它还通过分别招募组蛋白去乙酰化酶和NCOR1参与ASCL2和E2F响应启动子的转录抑制。JMJD2A是一种普遍表达的核蛋白。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    JMJD2A 抗体 (H-8) 参考文献:

    1. 组蛋白三甲基赖氨酸去甲基化酶JMJD2A可促进小鼠心脏肥大,以应对肥大的刺激。  |  Zhang, QJ., et al. 2011. J Clin Invest. 121: 2447-56. PMID: 21555854
    2. JMJD2A可预测人类胃癌的预后并调节细胞生长。  |  Hu, CE., et al. 2014. Biochem Biophys Res Commun. 449: 1-7. PMID: 24802408
    3. 组蛋白去甲基化酶JMJD2A通过转录因子ETV1驱动前列腺肿瘤的发生。  |  Kim, TD., et al. 2016. J Clin Invest. 126: 706-20. PMID: 26731476
    4. 异染色质组蛋白去甲基化酶JMJD2A的SUMO修饰可促进病毒基因转活和病毒复制。  |  Yang, WS., et al. 2017. PLoS Pathog. 13: e1006216. PMID: 28212444
    5. 组蛋白H3去甲基化酶JMJD2A通过上调miR372促进肝癌细胞的生长。  |  An, J., et al. 2017. Oncotarget. 8: 49093-49109. PMID: 28467776
    6. JMJD2A通过下调肿瘤抑制因子miR‑491‑5p促进宫颈癌细胞的生长并抑制其凋亡。  |  Li, Y., et al. 2019. Mol Med Rep. 19: 2489-2496. PMID: 30720092
    7. JMJD2A上调通过调节SLUG促进膀胱癌的迁移和侵袭。  |  Wang, F., et al. 2019. Oncol Rep. 42: 1431-1440. PMID: 31364745
    8. JMJD2A通过激活雄激素受体增强子并抑制cGAS-STING通路,促进去势抵抗性前列腺癌的发展。  |  Cai, X., et al. 2024. Mol Carcinog. 63: 1682-1696. PMID: 38818897
    9. JMJD2A在免疫逃逸和食管鳞状细胞癌恶性行为中的作用。  |  Su, X., et al. 2024. Int Immunopharmacol. 137: 112401. PMID: 38878485

    订购信息

    产品名称产品编号规格价格数量收藏夹

    JMJD2A 抗体 (H-8)

    sc-373850
    200 µg/ml
    RMB2377.00

    JMJD2A (H-8): m-IgGκ BP-HRP 套装

    sc-535318
    200 µg Ab; 40 µg BP
    RMB2662.00

    I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with JMJD2A (H-8): sc-373850?

    Asked by: Cweed
    We recommend using one of our our exclusive Mouse IgG Binding Proteins conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 5 out of 5 by from Good AntibodyI try the sample antibody, works very well for detect JMJD2A.
    Date published: 2017-09-21
    Rated 5 out of 5 by from Produced nice Western blot data of JMJD2AProduced nice Western blot data of JMJD2A expression in non-transfected and human JMJD2A transfected whole cell lysates. -SCBT QC
    Date published: 2013-07-07
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    JMJD2A抗体 (H-8) is rated 5.0 out of 5 by 2.
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