JAK3 Inhibitor V (CAS 4452-06-6)

物理状态 :

Solid

溶解度 :

Soluble in DMSO (10 mg/ml), and ethanol (10 mg/ml).

保存 :

Store at -20° C

熔点 :

75.35° C (Predicted)

沸点 :

~319.3° C at 760 mmHg (Predicted)

密度 :

~1.1 g/cm³ (Predicted)

折射率 :

n²⁰_D 1.62 (Predicted)

IC50 :

Inhibition of JAK-mediated interferon-gamma-induced Stat1 phosphorylation: IC₅₀ < 20 µM (BALB/c mouse CD8++ T cells); Inhibition of JAK-mediated interferon-gamma-induced Stat1 phosphorylation: IC₅₀ < 20 µM (BALB/c mouse CD4+ T cells); Inhibition of JAK-mediated IL6-induced Stat3 phosphorylation: IC₅₀ < 20 µM (BALB/c mouse CD11b-hi neutrophils); Inhibition of JAK-mediated IL7-induced Stat5 phosphorylation: IC₅₀ < 20 µM (BALB/c mouse CD11b-hi neutrophils); Inhibition of JAK-mediated IL15-induced Stat5 phosphorylation: IC₅₀ < 20 µM (BALB/c mouse CD4+ T cells)

PubChem CID :

MDL 号码 :

MFCD04974535

SMILES :

C=CC(=O)C1=CC2=CC=CC=C2C=C1