Date published: 2025-9-6

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IRF-2 抗体 (TQ-5): sc-101069

4.5(6)
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说明书
  • IRF-2抗体(TQ-5)是小鼠单克隆IgG2a κ, 在5篇文献中引用,规格为100 µg/ml
  • 免疫human物种的重组IRF-2
  • 推荐用于 human 来源的IRF-2 WB, IP, IF, IHC(P) 和 ELISA检测
  • 目前,我们还没有完成IRF-2 抗体 (TQ-5)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

干扰素调节因子-1(IRF-1)和IRF-2已被鉴定为新型DNA结合因子,它们作为I型干扰素(干扰素-α和β)和干扰素诱导基因的调节剂发挥作用。这两个因子在结构上相关,特别是在其N端区域,该区域赋予DNA结合特异性。此外,两者都与干扰素-α和干扰素-β基因启动子内的同一序列结合。IRF-1作为干扰素转录的激活剂发挥作用,而IRF-2与相同的顺式元件结合并抑制IRF-1的作用。据报道,IRF-1和IRF-2在调节细胞生长方面具有相互拮抗的作用;阻遏物IRF-2的过表达导致细胞转化,而IRF-1的同时过表达则引起逆转。IRF-1和IRF-2是更大的DNA结合蛋白家族的成员,该家族还包括IRF-3、IRF-4、IRF-5、IRF-6、IRF-7、ISGF-3γ p48(ISGF-3复合物的组成部分)和IFN共识序列结合蛋白(ICSBP)。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IRF-2 抗体 (TQ-5) 参考文献:

  1. 干扰素调节因子(IRF)-1 和 IRF-2 可调节干扰素γ 依赖性环氧化酶 2 的表达。  |  Blanco, JC., et al. 2000. J Exp Med. 191: 2131-44. PMID: 10859338
  2. IRF-2 通过不同的机制调节 B 细胞增殖和抗体生成。  |  Minamino, K., et al. 2012. Int Immunol. 24: 573-81. PMID: 22773153
  3. 干扰素调节因子(IRF)-1和IRF-2与肝癌的预后和肿瘤侵袭有关。  |  Yi, Y., et al. 2013. Ann Surg Oncol. 20: 267-76. PMID: 22805863
  4. IRF-2在结直肠癌中的表达具有预后价值。  |  Mei, Z., et al. 2017. Oncotarget. 8: 38969-38977. PMID: 28465494
  5. IRF-2单倍体缺陷会导致咪喹莫特诱导的银屑病样皮肤炎症增强。  |  Kawaguchi, M., et al. 2018. J Dermatol Sci. 90: 35-45. PMID: 29305258
  6. 小鼠骨髓移植过程中辐射损伤和再生期间干扰素调节因子(IRF-1和IRF-2)的表达。  |  Ahamad, N. and Rath, PC. 2019. Mol Biol Rep. 46: 551-567. PMID: 30488374
  7. TRIM14表达受IRF-1和IRF-2调控。  |  Cui, J., et al. 2019. FEBS Open Bio. 9: 1413-1420. PMID: 31150153
  8. IRF-2 通过下调 MMP-1 抑制胃癌的侵袭和迁移  |  Chen, YJ., et al. 2020. Dig Dis Sci. 65: 168-177. PMID: 31350707
  9. 干扰素调节因子 1(IRF-1)和 IRF-2 可调控肝细胞癌(HCC)细胞中 PD-L1 的表达。  |  Yan, Y., et al. 2020. Cancer Immunol Immunother. 69: 1891-1903. PMID: 32377817
  10. IRF-2通过促进人胃癌中AMER-1的转录抑制癌症增殖。  |  Chen, YJ., et al. 2022. J Transl Med. 20: 68. PMID: 35115027

订购信息

产品名称产品编号规格价格数量收藏夹

IRF-2 抗体 (TQ-5)

sc-101069
100 µg/ml
RMB2504.00

Can sc-101069: IRF-2 (TQ-5) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Germaine
Thank you for your question. Yes, sc-101069: IRF-2 (TQ-5) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from WB positive with BxPCWB positive with BxPC-3 cells. -SCBT Publication Review
Date published: 2015-04-06
Rated 4 out of 5 by from Good specificity and signal strength forGood specificity and signal strength for WB in HeLa nuclear extract. -SCBT QC
Date published: 2015-03-16
Rated 5 out of 5 by from Good nuclear staining with paraffinGood nuclear staining with paraffin-embedded human leiomyosarcoma tissue. -SCBT QC
Date published: 2015-03-07
Rated 4 out of 5 by from Satisfactory nuclear signal in HeLa cellsSatisfactory nuclear signal in HeLa cells. -SCBT QC
Date published: 2015-03-06
Rated 5 out of 5 by from Good specificity shown by using transfectedGood specificity shown by using transfected 293T cells and Jurkat whole cell lysates via Western Blot analysis. -SCBT QC
Date published: 2015-01-08
Rated 4 out of 5 by from Performs well in WesternPerforms well in Western, good signal strength in HeLa whole cell lysate. -SCBT QC
Date published: 2013-04-12
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IRF-2 抗体 (TQ-5) is rated 4.5 out of 5 by 6.
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