Date published: 2025-9-7
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INSR/Insulin Receptor β Antibody (C-4) - Western Blotting - Image 377371
胰岛素 Rβ 抗体 (C-4): sc-373975. MCF7 (A), Jurkat (B) 和 MDA-MB-435S (C) 全细胞裂解液中胰岛素 Rβ 表达的 Western 印迹分析.
胰岛素 Rβ 抗体 (C-4): sc-373975. MCF7 (A), Jurkat (B) 和 MDA-MB-435S (C) 全细胞裂解液中胰岛素 Rβ 表达的 Western 印迹分析.

INSR/Insulin Receptor β 抗体 (C-4): sc-373975

4.7(6)
寫評論提問

说明书
  • INSR/Insulin Receptor β抗体(C-4)是小鼠单克隆IgG2a κ, 在7篇文献中引用，规格为200 µg/ml
  • 免疫human物种的insulin Rβ的氨基酸941-1010
  • 抗-INSR/Insulin Receptor β 抗体 (C-4) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 insulin Rβ; 也和以下物种反应，包括： 和 equine, canine and porcine
  • 抗INSR/Insulin Receptor β抗体（C-4）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取INSR/Insulin Receptor β (C-4): sc-373975的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP、 2a BP-HRP">m-IgG2a BP-HRP和m-IgGκ BP-HRP是INSR/Insulin Receptor β Antibody (C-4) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与INSR/Insulin Receptor β Antibody (C-4) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

额外insulin R抗体，包括insulin R β

INSR/胰岛素受体β抗体（C-4）是一种IgG2aκ小鼠单克隆胰岛素Rβ抗体（也称为胰岛素Rβ抗体或胰岛素受体β抗体），可通过WB、IP、IF和ELISA检测小鼠、大鼠和人源的胰岛素Rβ。 INSR/胰岛素受体β抗体（C-4）可作为非偶联的抗胰岛素Rβ抗体，以及多种偶联形式的抗胰岛素Rβ抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。胰岛素受体（IR）是一种异二聚体蛋白复合物，具有细胞内β亚基和细胞外α亚基，α亚基与跨膜区以二硫键连接。胰岛素配体与IR结合并启动分子信号通路，促进细胞内葡萄糖摄取和糖原合成。胰岛素与IR结合诱导细胞内酪氨酸激酶结构域磷酸化，并募集多种含SH2和SH3结构域的细胞内蛋白，这些蛋白作为胰岛素多效作用的信号中间体。人类胰岛素受体基因位于染色体19p13.2上，编码1382个氨基酸的蛋白质，该蛋白质可切割形成α和β亚基。 1型糖尿病是一种内分泌胰腺的自身免疫性疾病，导致胰岛素分泌细胞破坏和细胞对胰岛素敏感的葡萄糖摄取逐渐减少。 2型糖尿病是一种细胞对胰岛素作用产生抗性的疾病。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

订购信息

产品名称产品编号规格价格数量收藏夹

INSR/Insulin Receptor β 抗体 (C-4)

sc-373975
200 µg/ml
RMB2377.00

INSR/Insulin Receptor β (C-4): m-IgG Fc BP-HRP 套装

sc-529625
200 µg Ab; 10 µg BP
RMB2662.00

INSR/Insulin Receptor β (C-4): m-IgGκ BP-HRP 套装

sc-522577
200 µg Ab, 40 µg BP
RMB2662.00

INSR/Insulin Receptor β (C-4): m-IgG2a BP-HRP 套装

sc-547343
200 µg Ab; 10 µg BP
RMB2662.00

INSR/Insulin Receptor β 抗体 (C-4) AC

sc-373975 AC
500 µg/ml, 25% agarose
RMB3129.00

INSR/Insulin Receptor β 抗体 (C-4) HRP

sc-373975 HRP
200 µg/ml
RMB2377.00

INSR/Insulin Receptor β 抗体 (C-4) FITC

sc-373975 FITC
200 µg/ml
RMB2482.00

INSR/Insulin Receptor β 抗体 (C-4) PE

sc-373975 PE
200 µg/ml
RMB2580.00

INSR/Insulin Receptor β 抗体 (C-4) Alexa Fluor® 488

sc-373975 AF488
200 µg/ml
RMB2685.00

INSR/Insulin Receptor β 抗体 (C-4) Alexa Fluor® 546

sc-373975 AF546
200 µg/ml
RMB2685.00

INSR/Insulin Receptor β 抗体 (C-4) Alexa Fluor® 594

sc-373975 AF594
200 µg/ml
RMB2685.00

INSR/Insulin Receptor β 抗体 (C-4) Alexa Fluor® 647

sc-373975 AF647
200 µg/ml
RMB2685.00

INSR/Insulin Receptor β 抗体 (C-4) Alexa Fluor® 680

sc-373975 AF680
200 µg/ml
RMB2685.00

INSR/Insulin Receptor β 抗体 (C-4) Alexa Fluor® 790

sc-373975 AF790
200 µg/ml
RMB2685.00

Can you tell me the molecular weight of INSR/Insulin Receptor β Antibody (CT-3) HRP?

Asked by: Leo Sun
Thank you for your question.The molecular weight is approximately 160 kDa.
Answered by: BlakeJ
Date published: 2023-05-31

What is the reason that this antibody recognises ~130 kDa protein, while other Santa Cruz antibodies vs. Insulin Receptor beta reveal a band around ~95 kDa?

Asked by: JulP
Thank you for your question. The 130 kDa processed insulin Rβ as detected by insulin Rβ Antibody (C-4): sc-373975 is described in PMID 2187866 “Processed 130-kDa alpha and 95-kDa beta subunits were also observed and contained approximately 20% as much protein as the proreceptor on a molar basis.” Please contact technical service for more information.
Answered by: SCBT Heidelberg Support
Date published: 2019-01-06

What is the recommended starting dilution for Western blot for sc-373975: insulin Rβ (C-4) monoclonal antibody?

Asked by: AbPolly
The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, is available in the recommended protocol: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2017-03-22
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Rated 5 out of 5 by from ExcellentI brought this product and i got excellent results. also the customer service and tech support are helpful
Date published: 2019-12-11
Rated 4 out of 5 by from No positivity in S. aurata and D. labrax tissuesAt the tested dilution (1:50, 1:200) and with the protocol in use in our laboratories, it was not possible to detect any positivity in Sparus aurata and Dicentrarchus labrax tissues
Date published: 2019-07-03
Rated 4 out of 5 by from IF on mouse mammary cancer cellAntibody – Santa Cruz 373975 anti-Insulin receptor beta Cell – mouse mammary cancer cell IF tested – dilution 1:50
Date published: 2017-12-18
Rated 5 out of 5 by from Excellent antibodyThe insulin R beta Antibody (C-4): sc-373975 works very well for detection of Insulin R via Western blot, showing strong and clean signal.
Date published: 2017-02-09
Rated 5 out of 5 by from Works well for WB in HeLa and JAR whole cellWorks well for WB in HeLa and JAR whole cell lysates. -SCBT QC
Date published: 2015-01-17
Rated 5 out of 5 by from Strong band observed in western blot analysisStrong band observed in western blot analysis of insulin R expression in Hep G2 whole cell lysate. -SCBT QC
Date published: 2013-12-04
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INSR/Insulin Receptor β 抗体 (C-4) is rated 4.7 out of 5 by 6.
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