Date published: 2025-9-8

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ILT 抗体 (A-9): sc-166580

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说明书
  • ILT抗体(A-9)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 与human的ILT-2的细胞外结构域内的氨基酸162-461杂交
  • 推荐用于 ILT famiy members 1, 2, 4, 5 and 6 of human origin, and the corresponding mouse and rat homologs WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是ILT Antibody (A-9) for WB applications. 的首选辅助检测试剂,这些试剂现与ILT Antibody (A-9) 打包提供(请参阅下面的订购信息)。

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    関連項目

    白细胞免疫球蛋白样受体(ILT,也称为LIR)是免疫球蛋白超家族的糖蛋白成员,主要由单核细胞、B细胞、树突状细胞、自然杀伤(NK)细胞、外周血白细胞以及胎盘、肺和肝等组织表达。ILT家族有几个成员,包括ILT-1、ILT-2、ILT-3、ILT-4、ILT-5、ILT-6、ILT-7、ILT-8、ILT-11、LIR-6和LIR-8。这些ILT蛋白分为两个亚家族,即亚家族A(ILT-1、ILT-6、ILT-7、ILT-8、ILT-11和LIR-6)和亚家族B(ILT-2、ILT-3、ILT-4、ILT-5和LIR-8),前者起刺激受体作用,后者起抑制受体作用。特征上,亚家族A的成员具有包含带电精氨酸残基的跨膜区域,通过该区域启动刺激性级联反应,而亚家族B的成员包含细胞质免疫受体酪氨酸基抑制基序(ITIM),通过该基序诱导抑制性信号级联反应。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    ILT 抗体 (A-9) 参考文献:

    1. 胰腺癌和可溶性免疫球蛋白样转录物3(ILT3)的作用。  |  Cortesini, R. 2007. JOP. 8: 697-703. PMID: 17993722
    2. 免疫球蛋白样转录物3是T细胞活化的抑制因子,在多发性硬化症复发期间,血液单核细胞中的免疫球蛋白样转录物3会减少,并且会受到干扰素β-1b的诱导。  |  Jensen, MA., et al. 2010. Mult Scler. 16: 30-8. PMID: 20007427
    3. 免疫球蛋白样转录物(ILT)2和ILT3在人胃癌中的表达及其临床意义。  |  Zhang, Y., et al. 2012. Mol Med Rep. 5: 910-6. PMID: 22246571
    4. 人皮肤CD14+树突状细胞上的免疫球蛋白样转录物受体作为CD8拮抗剂,控制细胞毒性T细胞的活化。  |  Banchereau, J., et al. 2012. Proc Natl Acad Sci U S A. 109: 18885-90. PMID: 23112154
    5. 银屑病关节炎患者免疫球蛋白样转录物4(ILT4)的下调。  |  Bergamini, A., et al. 2014. PLoS One. 9: e92018. PMID: 24676037
    6. 免疫球蛋白样转录物4和血管生成素样蛋白在人类非小细胞肺癌中的共同表达。  |  Wang, L., et al. 2015. Mol Med Rep. 11: 2789-96. PMID: 25482926
    7. 免疫球蛋白样转录物4可促进肿瘤进展和转移,并通过ERK信号通路上调非小细胞肺癌中VEGF-C的表达。  |  Zhang, P., et al. 2015. Oncotarget. 6: 13550-63. PMID: 25948790
    8. 免疫球蛋白样转录物4和人类白细胞抗原-G相互作用可促进人类结肠直肠癌的发展。  |  Cai, Z., et al. 2019. Int J Oncol. 54: 1943-1954. PMID: 30942436
    9. 免疫球蛋白样转录物4在肝细胞癌患者树突状细胞中的表达和功能。  |  Fan, J., et al. 2020. Hum Immunol. 81: 714-725. PMID: 33228921
    10. 肿瘤来源的免疫球蛋白样转录物4通过MAPK/ERK信号传导诱导血管生成模拟,从而促进肝细胞癌术后复发。  |  Li, J., et al. 2024. Am J Pathol. 194: 2398-2411. PMID: 39233275

    订购信息

    产品名称产品编号规格价格数量收藏夹

    ILT 抗体 (A-9)

    sc-166580
    200 µg/ml
    RMB2377.00

    ILT (A-9): m-IgG Fc BP-HRP 套装

    sc-540124
    200 µg Ab; 10 µg BP
    RMB2662.00

    ILT (A-9): m-IgG1 BP-HRP 套装

    sc-541918
    200 µg Ab; 20 µg BP
    RMB2662.00

    Pirb(C-19)sc-9609 is equal to this antibody(sc-166580)?

    Asked by: chenchen288
    Thank you for your question. ILT Antibody (A-9): sc-166580 is a mouse monoclonal IgG1 (kappa light chain) that was raised against amino acids 162-461 mapping within an extracellular domain of ILT-2 of human origin. It is recommended for detection of ILT famiy members 1, 2, 4, 5 and 6 of human origin, and the corresponding mouse and rat homologs by WB, IP, IF and ELISA. This antibody and the discontinued Pirb antibody sc-9609 both detect the same protein homologs, but have different species of origin, clonality and epitope.
    Answered by: Technical Support Europe
    Date published: 2019-04-23

    I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with ILT (A-9): sc-166580?

    Asked by: Randy McDonald
    We recommend using one of our our exclusive Mouse IgG Binding Proteins conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 5 out of 5 by from Good Western Blot data of ILTGood Western Blot data of ILT-4 expression in non-transfected and human ILT-4 transfected 293T whole cell lysates. -SCBT QC
    Date published: 2014-10-23
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    ILT 抗体 (A-9) is rated 5.0 out of 5 by 1.
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