Date published: 2026-10-24

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ILK 抗体 (E-2): sc-137221

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说明书
  • ILK抗体(E-2)是小鼠单克隆IgG3 κ, 在6篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的ILK-1的C-terminus的氨基酸434-452之间
  • 推荐用于 mouse, rat, human 和 来源的ILK-1 and ILK-2 WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 equine, canine, bovine, porcine and avian
  • 看 ILK (65.1): sc-20019,可查看有标记的 ILK 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG3 BP-HRP是ILK Antibody (E-2) 适用于 WB 应用。 的首选辅助检测试剂,该试剂现与ILK Antibody (E-2) 搭配使用(请参阅下面的订购信息)。
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ILK抗体(E-2)是一种IgG3 κ小鼠单克隆ILK抗体(也称为ILK抗体或整合素连接激酶(ILK)抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人的ILK-1和ILK-2。ILK抗体(E-2)为非偶联的抗ILK抗体形式。整合素是由非共价结合的跨膜α和β亚基组成的异二聚体。16个α亚基和8个β亚基异二聚化以产生20多种不同的受体。大多数整合素受体与作为细胞外基质组分的配体结合。某些整合素还可以与可溶性配体(如纤维蛋白原)或相邻细胞上的反向受体(如细胞内粘附分子(ICAM))结合,从而导致细胞聚集。除了介导细胞粘附和细胞骨架组织外,整合素还起信号受体的作用。整合素转导的信号在许多生物学过程中发挥作用,包括细胞生长、分化、迁移和凋亡。ILK(整合素连接激酶)被鉴定为能磷酸化β1和β3整合素的丝氨酸/苏氨酸激酶。已证实,在整合素配体纤连蛋白的作用下,ILK的表达减少。研究表明,ILK的过度表达可上调上皮细胞中纤连蛋白基质装配,这表明ILK在细胞生长、细胞存活和肿瘤发生中具有潜在作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ILK 抗体 (E-2) 参考文献:

  1. 整合素相关激酶(ILK)在癌症进展中的作用。  |  Persad, S. and Dedhar, S. 2003. Cancer Metastasis Rev. 22: 375-84. PMID: 12884912
  2. PINCH-ILK-parvin复合物:组装、功能和调节。  |  Wu, C. 2004. Biochim Biophys Acta. 1692: 55-62. PMID: 15246679
  3. ILK:细胞-基质粘附和信号传导中心阶段的假激酶。  |  Qin, J. and Wu, C. 2012. Curr Opin Cell Biol. 24: 607-13. PMID: 22763012
  4. ILK与炎症有关。  |  Plow, EF. and Simon, DI. 2020. Blood. 136: 2097-2099. PMID: 33152089
  5. 整合素相关激酶(ILK)及其在肝脏病理生物学中的作用。  |  Martucci, N., et al. 2021. Gene Expr. 20: 201-207. PMID: 33482930
  6. 内皮素-1通过ILK驱动内陷并与间皮细胞相互作用。  |  Masi, I., et al. 2021. Cell Rep. 34: 108800. PMID: 33657382
  7. 假激酶ILK介导的肌动蛋白组装的表征。  |  Vaynberg, J. and Qin, J. 2022. Methods Enzymol. 667: 123-146. PMID: 35525540
  8. iPsc-MSC产生的胞外囊泡通过ILK-PI3K/AKT通路减轻化疗对小鼠卵巢的损伤。  |  Cao, RC., et al. 2023. Zool Res. 44: 620-635. PMID: 36866625
  9. 在子宫内膜异位症的发病过程中,MCP-1通过激活ILK发挥炎症反应。  |  Soni, UK., et al. 2024. Life Sci. 353: 122902. PMID: 39004271
  10. RNF19A通过调节ILK泛素化和激活AKT/mTOR信号通路抑制膀胱癌的进展。  |  Deng, H., et al. 2024. Biol Direct. 19: 102. PMID: 39508245

订购信息

产品名称产品编号规格价格数量收藏夹

ILK 抗体 (E-2)

sc-137221
200 µg/ml
CNY2422.00

ILK (E-2): m-IgG3 BP-HRP 套装

sc-552946
200 µg Ab; 40 µg BP
CNY2715.00

ILK (E-2) 中和勝肽

sc-137221 P
100 µg/0.5 ml
CNY519.00

What application is the blocking peptide sc-137221 P appropriate for?

Asked by: Cweed
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by Constanze from Good antibody for WBGives strong bands in WB on human podocyte lysates.
Date published: 2022-01-28
Rated 5 out of 5 by jenniferc from Nice resultsILK Antibody (E-2) produced very nice bands with little to no background
Date published: 2017-01-24
Rated 5 out of 5 by Anon from Used for immunofluorescence of HSCs fixedUsed for immunofluorescence of HSCs fixed in 4% pfa for 15 mins.
Date published: 2015-07-31
Rated 5 out of 5 by SH from StrongStrong, clean bands in western blot analysis of ILK expression in NIH/3T3 and HeLa whole cell lysate. -SCBT QC
Date published: 2015-04-30
Rated 5 out of 5 by KG from Published western blot data using LNCaPPublished western blot data using LNCaP, CWR22v1, PC-3M and PC-3S whole cell lysates. -SCBT Publication Review
Date published: 2015-02-18
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ILK 抗体 (E-2) is rated 4.8 out of 5 by 5.
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