Date published: 2025-9-7

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IL-4 抗体 (HIL41): sc-12723

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说明书
  • IL-4 抗体 HIL41 是小鼠单克隆 IgG2b κ,IL-4抗体, 在5篇文献中引用,规格为200 µg/ml
  • 针对全长IL-4,human起源
  • IL-4 抗体 (HIL41) 推荐用于WB, IP, IF 和 ELISA,检测human 来源的 IL-4
  • 看 IL-4 (HIL44): sc-13555,可查看有标记的 IL-4 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP是IL-4 Antibody (HIL41) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与IL-4 Antibody (HIL41) 搭配使用(请参阅下面的订购信息)。

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関連項目

IL-4抗体(HIL41)是一种小鼠单克隆IgG2b kappa轻链抗体,可通过WB、IP、IF和ELISA检测人源IL-4蛋白。IL-4抗体(HIL41)有非结合型和多种结合型,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®结合型。白细胞介素-4(IL-4)也称为B细胞刺激因子-1,是一种主要由活化的T淋巴细胞、嗜碱性粒细胞和肥大细胞分泌的糖基化细胞因子。IL-4在免疫系统中起着至关重要的作用,它能够促进免疫细胞的生长和分化,特别是通过增强Th2细胞系,同时抑制Th1细胞的发展。这些辅助性T细胞亚群之间的平衡对于协调适当的免疫反应至关重要;Th1细胞与促炎反应有关,而Th2细胞则与过敏反应和对寄生虫感染的反应有关。此外,IL-4对于免疫球蛋白类别的转换至关重要,它能够特异性地诱导IgE的产生,并增强B细胞分泌的IgG4,同时抑制其他免疫球蛋白类别的产生,如IgM、IgA、IgG1、IgG2和IgG3。值得注意的是,IL-4激活的信号通路涉及Stat6的快速酪氨酸磷酸化,这是调节免疫细胞功能的关键步骤。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IL-4 抗体 (HIL41) 参考文献:

  1. 姜黄素通过分泌 IL-4 和/或 IL-13 诱导 M2 巨噬细胞极化。  |  Gao, S., et al. 2015. J Mol Cell Cardiol. 85: 131-9. PMID: 25944087
  2. IL-4的功能及其表达控制。  |  Brown, MA. and Hural, J. 2017. Crit Rev Immunol. 37: 181-212. PMID: 29773020
  3. IL-4偏振的BV2小胶质细胞通过分泌外泌体促进血管生成。  |  Tian, Y., et al. 2019. Adv Clin Exp Med. 28: 421-430. PMID: 30684318
  4. IL-4、IL-13及其受体在胰腺癌中的参与。  |  Shi, J., et al. 2021. Int J Mol Sci. 22: PMID: 33804263
  5. IL-4偏振的人巨噬细胞外泌体控制肥胖症的心脏代谢炎症和糖尿病。  |  Phu, TA., et al. 2022. Mol Ther. 30: 2274-2297. PMID: 35292359
  6. IL-13/IL-4信号传导有助于骨髓增生性肿瘤的纤维化进展。  |  Melo-Cardenas, J., et al. 2022. Blood. 140: 2805-2817. PMID: 36283106
  7. 通过同时刺激LPS和IL-4诱导独特的巨噬细胞亚群。  |  Ishida, K., et al. 2023. Front Immunol. 14: 1111729. PMID: 37180123
  8. IL-4在出生后的发育过程中,影响小胶质细胞依赖的小脑修剪。  |  Guedes, JR., et al. 2023. Neuron. 111: 3435-3449.e8. PMID: 37918358
  9. 骨髓中的IL-4信号轴驱动促肿瘤性骨髓生成。  |  LaMarche, NM., et al. 2024. Nature. 625: 166-174. PMID: 38057662
  10. 卵巢癌来源的IL-4促进免疫治疗耐药性。  |  Mollaoglu, G., et al. 2024. Cell. 187: 7492-7510.e22. PMID: 39481380

订购信息

产品名称产品编号规格价格数量收藏夹

IL-4 抗体 (HIL41)

sc-12723
200 µg/ml
RMB2377.00

IL-4 (HIL41): m-IgG Fc BP-HRP 套装

sc-525460
200 µg Ab; 10 µg BP
RMB2662.00

How can IL-4 (HIL41): sc-12723 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: jerojero
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to HRP (sc-12723 HRP), phycoerythrin (sc-12723 PE), fluoroscein (sc-12723 FITC) and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from excelenteme gusto mucho y funcionaba muy bien junto con otros reactivos
Date published: 2022-03-14
Rated 5 out of 5 by from good jobIL-4 and IL-6 antibody worked well in liver normal cell L02 in WB by 1:500
Date published: 2017-11-22
Rated 5 out of 5 by from *echantillon de qualitéEchantillon gratuit reçu très rapidement, a permis de réaliser un test de qualité (WB)
Date published: 2017-10-08
Rated 5 out of 5 by from Great feutureGood band was observed in western blotting in mouse samples.
Date published: 2017-08-21
Rated 3 out of 5 by from No band in airway smooth muscle cell westernNo band in western from 15ug total protein using human airway smooth muscle cell lysates (1:200).
Date published: 2017-07-31
Rated 2 out of 5 by from Band seen in WB using human recombinant ILBand seen in WB using human recombinant IL-4. -SCBT QC
Date published: 2015-07-18
Rated 2 out of 5 by from Publishable data in IHC using human bronchiaPublishable data in IHC using human bronchia sections -SCBT Publication Review
Date published: 2014-08-16
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IL-4 抗体 (HIL41) is rated 3.9 out of 5 by 7.
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