Date published: 2025-9-7

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IL-2Rα 抗体 (BC96): sc-19628

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说明书
  • IL-2Rα抗体(BC96)是小鼠单克隆IgG1 κ, 在1篇文献中引用,规格为200 µg/ml
  • 免疫human物种的IL-2Rα
  • 推荐用于 human 来源的IL-2Rα FCM检测
  • 可提供偶联藻红蛋白, FITC, Alexa Fluor® 488 或者Alexa Fluor® 647 的产品, 应用于IF, IHC(P)和FCM
  • m-IgG Fc BP-HRPm-IgGκ BP-HRP是IL-2Rα Antibody (BC96). 的首选辅助检测试剂,这些试剂现与IL-2Rα Antibody (BC96) 打包提供(请参阅下面的订购信息)。

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IL-2Rα抗体(BC96)是一种小鼠单克隆IgG1抗体,可通过流式细胞术(FCM)检测人类样本中的IL-2Rα。IL-2Rα也称为CD25,作为白介素-2(IL-2)的高亲和力受体在免疫系统中发挥着至关重要的作用,而IL-2是参与T细胞增殖和分化的关键细胞因子。T细胞上的IL-2Rα表达对于其活化和存活至关重要,这使得IL-2Rα成为免疫反应中的关键组成部分,尤其是在T细胞介导的免疫和耐受方面。值得注意的是,IL-2Rα主要在活化的T细胞、调节性T细胞和某些造血细胞上表达,这凸显了IL-2Rα在调节免疫反应和维持体内平衡方面的重要性。IL-2Rα与IL-2相互作用不仅促进T细胞生长,还影响各种免疫细胞类型的发展,从而影响整体免疫功能。鉴于IL-2Rα在免疫调节中的关键作用,它已成为研究免疫疾病、癌症免疫疗法和T细胞激活机制的重要标志物。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IL-2Rα 抗体 (BC96) 参考文献:

  1. 用达克珠单抗调节IL-2Rα治疗多发性硬化症。  |  Wiendl, H. and Gross, CC. 2013. Nat Rev Neurol. 9: 394-404. PMID: 23732529
  2. IL-2Rα介导IL-2信号传导的时序调控并增强免疫治疗。  |  Su, EW., et al. 2015. Sci Transl Med. 7: 311ra170. PMID: 26511507
  3. Tfr细胞缺乏IL-2Rα,但表达诱饵IL-1R2和IL-1Ra,并抑制IL-1依赖性Tfh细胞的激活。  |  Ritvo, PG., et al. 2017. Sci Immunol. 2: PMID: 28887367
  4. PPARγ的激活通过上调CD36/CPT1介导的脂肪酸氧化和随后TβRII/IL-2Rα的N-糖苷分支,增强调节性T细胞的反应。  |  Miao, Y., et al. 2022. Cell Commun Signal. 20: 48. PMID: 35392915
  5. IL-2/IL-2R信号传导和IL-2Rα靶向治疗间变性大细胞淋巴瘤。  |  Liang, HC. 2022. Pathologie (Heidelb). 43: 25-30. PMID: 36094651
  6. IL-2与IL-2Rα的近程共价结合选择性地激活调节性T细胞并抑制自身免疫。  |  Zhang, B., et al. 2023. Signal Transduct Target Ther. 8: 28. PMID: 36690610
  7. IL-2Rα受体激动剂通过激活肿瘤浸润性CD25+CD8+ T细胞增强抗肿瘤免疫。  |  Wu, W., et al. 2023. Nat Cancer. 4: 1309-1325. PMID: 37550516
  8. 羊膜间充质干细胞通过下调IL-12Rβ1和IL-2Rα信号通路,影响CD8未分化细胞向SLEC/MPEC亚群的极化。  |  Papait, A., et al. 2023. iScience. 26: 108483. PMID: 38077154
  9. 斑蝥素通过活性氧克服IL-2Rα信号传导介导的伏立诺他耐药性皮肤T细胞淋巴瘤。  |  Zhu, M., et al. 2024. J Immunother Cancer. 12: PMID: 39004437
  10. 一种针对PD-1受体、受体掩蔽的IL-2免疫细胞因子,与IL-2Rα结合,可增强T细胞介导的抗肿瘤疗法。  |  Wu, J., et al. 2024. Cell Rep Med. 5: 101747. PMID: 39326410

订购信息

产品名称产品编号规格价格数量收藏夹

IL-2Rα 抗体 (BC96)

sc-19628
200 µg/ml
RMB2377.00

IL-2Rα (BC96): m-IgG Fc BP-HRP 套装

sc-536624
200 µg Ab; 10 µg BP
RMB2662.00

IL-2Rα (BC96): m-IgGκ BP-HRP 套装

sc-533781
200 µg Ab; 40 µg BP
RMB2662.00

IL-2Rα 抗体 (BC96) Alexa Fluor® 488

sc-19628 AF488
200 µg/ml
RMB2685.00

IL-2Rα 抗体 (BC96) Alexa Fluor® 647

sc-19628 AF647
200 µg/ml
RMB2685.00

IL-2Rα 抗体 (BC96) FITC

sc-19628 FITC
200 µg/ml
RMB2482.00

IL-2Rα 抗体 (BC96) PE

sc-19628 PE
200 µg/ml
RMB2580.00

Does this antibody block IL2 binding or interfere with IL2 signaling?

Asked by: Labrat2
Thank you for your question. It would be helpful if you could call us directly at 800-457-3801 ext 1, allowing for a more interactive discussion of this and other related questions.
Answered by: Blake J
Date published: 2021-08-19

Hi, I have bought this antibody CD25 sc-19628 and from the data sheet provided I don't seem to get where your dilutions recommendation. Could you kindly give a directive or guidance on this please.

Asked by: Asman
Thank you for your question. This mouse monoclonal antibody, IL-2Rα (BC96): sc-19628, is recommended for detection of IL-2Rα of human origin by flow cytometry at a concentration of 1 μg per 1 million cells. This information is shown under the "Applications" section of our product data sheet. A link to our recommended protocol is provided below as an additional reference. https://www.scbt.com/scbt/resources/protocols/flow-cytometry
Answered by: Technical Support
Date published: 2017-08-23

How can IL-2Rα (BC96): sc-19628 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: Germaine
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to phycoerythrin (sc-19628 PE) or fluoroscein (sc-19628 FITC).
Answered by: Technical Support
Date published: 2017-02-27

Can i use this clone for blocking IL-2r?

Asked by: mariana
  • y_2025, m_9, d_7, h_4CST
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Rated 4 out of 5 by from Produced clear FCM data for PMAProduced clear FCM data for PMA-stimulated human peripheral blood leukocytes stained with IL-2R alpha FITC and CD4 PE. -SCBT QC
Date published: 2013-11-28
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IL-2Rα 抗体 (BC96) is rated 4.0 out of 5 by 1.
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