Date published: 2025-9-8

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IL-12B p40 抗体 (C17.8): sc-57258

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说明书
  • IL-12B p40 抗体 C17.8 是大鼠单克隆 IgG2a, 在9篇文献中引用,提供 200 µg/ml
  • 针对全长IL-12B p40,mouse起源
  • 推荐用于 mouse 来源的IL-12B p40 WB, IP, IF, IHC(P) 和 ELISA检测; 还建议用于检测IL-12/IL-23 p40 subunit (monomer, homodimer and heterodimer IL-12 p35/p40 or IL-23 p19/p40)
  • 还提供无叠氮化物的中和研究,sc-57258 L,200 µg/0.1 ml
  • 目前,我们还没有完成IL-12B p40 抗体 (C17.8)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

IL-12B p40抗体(C17.8)是一种鼠单克隆IgG2a抗体,可通过多种应用检测小鼠样本中的IL-12B p40,包括蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组织化学(IHCP)和酶联免疫吸附测定(ELISA)。IL-12B p40作为异二聚体细胞因子白介素-12(IL-12)的亚基,在免疫反应中起着至关重要的作用,对于将幼稚CD4(+) T细胞分化成产生干扰素-γ(IFN-γ)的1型辅助性T细胞至关重要。这一过程对于激活T细胞和自然杀伤(NK)细胞至关重要,而T细胞和NK细胞是人体抵御感染和肿瘤的关键。此外,IL-12B p40可与p19结合形成白细胞介素23(IL-23),这种细胞因子与IL-12具有一些相同的特性,包括激活转录因子Stat4和促进IFN-γ的产生。IL-12B p40能够同时影响IL-12和IL-23通路,这凸显了其在调节免疫反应和维持免疫平衡方面的重要性,因此抗IL-12B p40抗体(C17.8)成为研究人员在小鼠模型中研究细胞因子信号传导和免疫功能的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IL-12B p40 抗体 (C17.8) 参考文献:

  1. IL12B 基因不会导致乳糜泻的易感性。  |  Louka, AS., et al. 2002. Tissue Antigens. 59: 70-2. PMID: 11972887
  2. IL12B 基因 3' UTR 的多态性与南美锥虫病心肌病有关。  |  Zafra, G., et al. 2007. Microbes Infect. 9: 1049-52. PMID: 17644387
  3. 多发性硬化症中与自身免疫性疾病相关的 IL12B 和 IL23R 多态性。  |  Begovich, AB., et al. 2007. Hum Immunol. 68: 934-7. PMID: 18082575
  4. IL12B 和 IL23R 基因的多态性与银屑病有关。  |  Nair, RP., et al. 2008. J Invest Dermatol. 128: 1653-61. PMID: 18219280
  5. IL12A 和 IL12B 多态性对宫颈癌风险的影响。  |  Roszak, A., et al. 2012. Pathol Oncol Res. 18: 997-1002. PMID: 22614250
  6. IL-10通过组蛋白去乙酰化调节Il12b的表达:对肠道巨噬细胞稳态的影响  |  Kobayashi, T., et al. 2012. J Immunol. 189: 1792-9. PMID: 22786766
  7. IL12B、IL1B 和 TNFA 基因的多态性与哮喘的易感性。  |  Padrón-Morales, J., et al. 2013. J Investig Allergol Clin Immunol. 23: 487-94. PMID: 24654313
  8. 细胞因子基因多态性(IL-6、IL-12B、IL-18)与白塞氏病的关系:荟萃分析  |  Xu, Y., et al. 2016. Z Rheumatol. 75: 932-938. PMID: 26800664
  9. CD84、IL12B 和 TNFAIP3 的多态性与银屑病患者对生物制剂的反应有关。  |  van den Reek, JMPA., et al. 2017. Br J Dermatol. 176: 1288-1296. PMID: 27564082
  10. IL18多态性与牙周炎易感性,与IL12B、MMP9和吸烟习惯无关。  |  Tsuneto, PY., et al. 2019. Mediators Inflamm. 2019: 9585964. PMID: 31065235

订购信息

产品名称产品编号规格价格数量收藏夹

IL-12B p40 抗体 (C17.8)

sc-57258
200 µg/ml
RMB2377.00

IL-12B p40 抗体 (C17.8) L

sc-57258 L
200 µg/0.1 ml
RMB2377.00

could i know what is the difference between using the FUll length Versus the L from IL12B p40 C17.8; sc-57258? is the L one manufacture for not detect the heterodimer of the il12 protein

Asked by: Shorouk
Thank you for the question. The "L" form on the antibody is just an azide-free form of the antibody, usually used for neutralization studies, sc-57258 L. It is the same antibody as the non L form, so they will both detect the same protein.
Answered by: Tech Service
Date published: 2019-03-20

I bought the L form of this antibody, sc-57258 L for blocking (neutralization). How long can I store this at in the refridgerator?

Asked by: AbPolly
The L form of the antibody should be stored at -20°C. Once thawed, we recommend using as soon as possible, although it is usually stable for up to 2 weeks at 4 degrees.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Versatile Antibody for Mouse SamplesThis antibody is well-cited for a variety of applications including WB, IP, IF, and even IHC and ELISA. Strong, clear signal with little to no background. Beautiful tissue staining.
Date published: 2017-02-08
Rated 3 out of 5 by from Nice band seen in WB using mouse recombinant ILNice band seen in WB using mouse recombinant IL-12B p40. -SCBT QC
Date published: 2013-02-24
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IL-12B p40 抗体 (C17.8) is rated 4.0 out of 5 by 2.
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