Date published: 2025-9-8

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IL-11Rα 抗体 (4D12): sc-130920

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说明书
  • IL-11R alpha 抗体 4D12 是小鼠单克隆 IgG1 κ,IL-11Rα抗体, 在10篇文献中引用,规格为200 µg/ml
  • 针对human来源的可溶性IL-11Rα重组蛋白
  • IL-11R alpha 抗体 (4D12) 推荐用于 WB, IP, IF, IHC(P) 和 FCM,检测mouse, rat 和human 来源的 IL-11Rα
  • 抗IL-11R alpha抗体(4D12)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取IL-11Rα (4D12): sc-130920免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 IL-11Rα 抗体 (4D12) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与IL-11Rα 抗体 (4D12) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

IL-11Rα抗体(4D12)是一种IgG1 κ小鼠单克隆IL-11R alpha抗体(也称为IL-11Rα抗体),可通过WB、IP、IF、IHC(P)和FCM检测小鼠、大鼠和人源的IL-11R alpha蛋白。IL-11Rα抗体(4D12)既可以是非偶联的抗IL-11R alpha抗体形式,也可以是多种偶联形式的抗IL-11R alpha抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。多效性细胞因子IL-11已被证明对淋巴系、髓系和红系细胞具有增殖和分化作用。IL-11还具有体外抑制脂肪生成的抑制作用。IL-11α受体,即IL-11Rα,是细胞因子受体家族I类亚组的成员,与人类睫状神经营养因子(CNTF)的α亚基和小鼠IL-6受体具有结构相似性。推测IL-11Rα调节成骨祖细胞和间充质细胞的增殖和/或分化。gp130和IL-11α的共表达对于IL-11与IL-11Rα的高亲和力结合是必要的。研究还发现,IL-11Rα和gp130的共表达是适当刺激Ba/F3细胞分化为巨噬细胞以响应IL-11所必需的。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IL-11Rα 抗体 (4D12) 参考文献:

  1. IL-11和IL-11Ralpha在灵长类动物植入部位的免疫定位支持IL-11在胎盘和胎儿发育中的作用。  |  Dimitriadis, E., et al. 2003. Reprod Biol Endocrinol. 1: 34. PMID: 12740032
  2. IL-11Rα:治疗骨肉瘤的新靶点。  |  Lewis, VO. 2014. Adv Exp Med Biol. 804: 285-9. PMID: 24924180
  3. IL-11Rα靶向纳米策略增强了复发性和患者源性骨肉瘤的化疗效果。  |  Jiang, J., et al. 2022. J Control Release. 350: 460-470. PMID: 36041590
  4. 白细胞介素(IL)-11/IL-11R在骨代谢和稳态中的新兴作用:从细胞因子到骨因子。  |  Dong, B., et al. 2023. Aging Dis. 14: 2113-2126. PMID: 37199584
  5. 以IL-11系统为靶点治疗肺动脉高压。  |  Milara, J., et al. 2023. Pharmacol Res. 197: 106985. PMID: 37949331
  6. 在肺动脉高压相关性肺纤维化动物模型中,通过靶向IL-11减少纤维细胞循环和肺部积聚。  |  Milara, J., et al. 2024. Br J Pharmacol. 181: 2991-3009. PMID: 38679415
  7. FLT3 配体在体外直接有效地刺激原始小鼠骨髓祖细胞的生长和扩增:与白细胞介素(IL)11, IL-12 和其他造血生长因子的协同作用。  |  Jacobsen, SE., et al. 1995. J Exp Med. 181: 1357-63. PMID: 7535335
  8. 用IL-3, IL-6, IL-11和SCF培养扩增的小鼠骨髓细胞在正常宿主体内会出现移植缺陷。  |  Peters, SO., et al. 1995. Exp Hematol. 23: 461-9. PMID: 7536685
  9. IL-11,一种多效细胞因子:IL-11 对胃肠道粘膜生物学产生的令人兴奋的新影响。  |  Keith, JC., et al. 1994. Stem Cells. 12 Suppl 1: 79-89; discussion 89-90. PMID: 7696971
  10. Etl2,一种在小鼠胚胎发育过程中在皮肤和具有骨骼生成潜能的细胞中高水平表达的新型推定 I 型细胞因子受体。  |  Neuhaus, H., et al. 1994. Dev Biol. 166: 531-42. PMID: 7813775
  11. 小鼠 IL-11 受体α-链的克隆;高亲和力结合和信号转导需要 gp130。  |  Hilton, DJ., et al. 1994. EMBO J. 13: 4765-75. PMID: 7957045
  12. 回顾一种新型造血细胞因子--白细胞介素-11。  |  Quesniaux, VF., et al. 1993. Int Rev Exp Pathol. 34 Pt A: 205-14. PMID: 8454414

订购信息

产品名称产品编号规格价格数量收藏夹

IL-11Rα 抗体 (4D12)

sc-130920
200 µg/ml
RMB2377.00

IL-11Rα (4D12): m-IgG Fc BP-HRP 套装

sc-528739
200 µg Ab; 10 µg BP
RMB2662.00

IL-11Rα (4D12): m-IgGκ BP-HRP 套装

sc-521220
200 µg Ab, 40 µg BP
RMB2662.00

IL-11Rα (4D12): m-IgG1 BP-HRP 套装

sc-543105
200 µg Ab; 20 µg BP
RMB2662.00

IL-11Rα 抗体 (4D12) AC

sc-130920 AC
500 µg/ml, 25% agarose
RMB3129.00

IL-11Rα 抗体 (4D12) HRP

sc-130920 HRP
200 µg/ml
RMB2377.00

IL-11Rα 抗体 (4D12) FITC

sc-130920 FITC
200 µg/ml
RMB2482.00

IL-11Rα 抗体 (4D12) PE

sc-130920 PE
200 µg/ml
RMB2580.00

IL-11Rα 抗体 (4D12) Alexa Fluor® 488

sc-130920 AF488
200 µg/ml
RMB2685.00

IL-11Rα 抗体 (4D12) Alexa Fluor® 546

sc-130920 AF546
200 µg/ml
RMB2685.00

IL-11Rα 抗体 (4D12) Alexa Fluor® 594

sc-130920 AF594
200 µg/ml
RMB2685.00

IL-11Rα 抗体 (4D12) Alexa Fluor® 647

sc-130920 AF647
200 µg/ml
RMB2685.00

IL-11Rα 抗体 (4D12) Alexa Fluor® 680

sc-130920 AF680
200 µg/ml
RMB2685.00

IL-11Rα 抗体 (4D12) Alexa Fluor® 790

sc-130920 AF790
200 µg/ml
RMB2685.00

请问IL11R 4D12这个抗体在ELISA实验中的功能效果如何?

Asked by: xyxmmmm
感谢您的提问。您可以拨打电话:021-60936350,发送邮件到[email protected],或者我们官网上的在线聊天,联系我们的亚洲技术支持团队,了解更多信息。 Thank you for your question. Please contact our Technical Service Department for more information. Our Asian Technical Service team is available at (+86) 021-60936350 or [email protected] or by live chat on our website.
Answered by: Technical Service SH
Date published: 2025-08-11

Can IL11R (4D12): sc-130920 be used in ELISA experiments, and how effective is it ?

Asked by: xyxmmmm
Thanks for your question.IL-11Rα Antibody (4D12): sc-130920 has not tested on ELISA.So we don't provide warranty for ELISA application at this time. 谢谢您的问题。IL-11Rα抗体(4D12): sc-130920未验证ELISA实验。所以我们目前不质保ELISA应用。
Answered by: Yanru Tao
Date published: 2025-08-08

Is this antibody is specific to a certain portion of IL11RA? For flow cytometry, is it able to detect the surface (extracellular) portion of IL11RA in live cells or does it require fix/perm before staining?

Asked by: bflynn
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Dallas Tech Service
Date published: 2022-12-27

Can IL-11Rα (4D12): sc-130920 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: jenniferc
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, IL-11Rα (4D12): sc-130920 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2022-12-27
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Rated 4 out of 5 by from Research ScientistWe bought products from this company a few times and the they work very well.
Date published: 2022-05-23
Rated 1 out of 5 by from Didn't workI tested this Ab for FlowCytometry and it didn't work. Also, the vial contained an inclusion visible to the naked eye indicating aggregation.
Date published: 2020-10-08
Rated 4 out of 5 by from Fitc labelled antibody for Flow Cytometryused this antibody for flow cytometry, and it worked lovely. I would highly recommend this antibody for flow cytometry.
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IL-11Rα 抗体 (4D12) is rated 3.0 out of 5 by 5.
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