Date published: 2025-9-7

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IL-10Rβ 抗体 (F-6): sc-271969

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说明书
  • IL-10R beta 抗体 F-6 是小鼠单克隆 IgG1 κ,IL-10Rβ抗体, 在5篇文献中引用,规格为200 µg/ml
  • 特定于human起源的IL-10Rβ细胞质域内氨基酸251-281之间的表位图谱
  • IL-10R beta 抗体 (F-6) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 IL-10Rβ
  • 抗IL-10R beta抗体(F-6)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取IL-10Rβ (F-6): sc-271969免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是IL-10Rβ Antibody (F-6) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与IL-10Rβ Antibody (F-6) 打包提供(请参阅下面的订购信息)。

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関連項目

IL-10Rβ抗体(F-6)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的IL-10Rβ蛋白。IL-10Rβ (F-6) 抗体有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。IL-10Rβ(F-6)单克隆抗体靶向一种在免疫调节中发挥关键作用的受体,该受体通过介导白细胞介素-10(IL-10)的抗炎作用发挥其功能,而IL-10是一种对控制免疫反应和防止过度炎症至关重要的细胞因子。IL-10Rβ在包括B细胞和T辅助细胞在内的各种免疫细胞中表达,对于形成功能性IL-10受体复合物至关重要。IL-10Rβ还与IL-22R和IL-28R亚基形成异二聚体,从而扩展其在细胞因子信号传导中的作用。IL-10Rβ调节免疫反应的能力在自身免疫性疾病和慢性炎症等疾病中尤为重要,因为IL-10信号传导有助于恢复平衡和促进愈合。IL-10Rβ在人类自然杀伤(NK)细胞中具有固有表达,与IL-10的直接相互作用可促进细胞因子的产生,凸显其在先天免疫中的重要性。抗IL-10Rβ抗体(F-6)是研究人员研究免疫调节复杂机制和靶向IL-10信号通路治疗潜力的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IL-10Rβ 抗体 (F-6) 参考文献:

  1. 自分泌 IL-10 对树突状细胞功能的调节作用  |  Corinti, S., et al. 2001. J Immunol. 166: 4312-8. PMID: 11254683
  2. 新型干扰素  |  Vilcek, J. 2003. Nat Immunol. 4: 8-9. PMID: 12496969
  3. 在人类原发性前列腺癌细胞系中,通过 IL-10E1 发出的 IL-10 信号依赖于 IL-10R alpha 链中的酪氨酸磷酸化。  |  Stearns, ME., et al. 2003. Oncogene. 22: 3781-91. PMID: 12802285
  4. 尖端技术:IL-26 通过由 IL-20 受体 1 和 IL-10 受体 2 组成的新型受体复合物发出信号。  |  Sheikh, F., et al. 2004. J Immunol. 172: 2006-10. PMID: 14764663
  5. HLA相同同胞供体造血干细胞移植后,IL-10和IL-10Rβ基因多态性与移植物抗宿主病有关。  |  Sivula, J., et al. 2009. BMC Immunol. 10: 24. PMID: 19409109
  6. IL-10受体β的多态性影响接受沙利度胺和/或硼替佐米治疗的多发性骨髓瘤患者的预后。  |  Kasamatsu, T., et al. 2017. Hematol Oncol. 35: 711-718. PMID: 27405747
  7. IL-28A/IL-10Rβ轴通过调节HSP70-1表达,通过eNOS/AKT信号传导和AP-1/NF-κB/MMP-2网络促进血管生成。  |  Song, JH., et al. 2024. J Adv Res.. PMID: 39127098
  8. 人类自然杀伤细胞上白细胞介素-10 受体表达的功能特征。  |  Carson, WE., et al. 1995. Blood. 85: 3577-85. PMID: 7540068
  9. 小鼠白细胞介素-10 受体胞质结构域的功能区。  |  Ho, AS., et al. 1995. Mol Cell Biol. 15: 5043-53. PMID: 7544437
  10. 重组人白细胞介素-10 受体胞外结构域的特征。  |  Tan, JC., et al. 1995. J Biol Chem. 270: 12906-11. PMID: 7759550
  11. 脂多糖依赖性诱导小鼠成纤维细胞表达 IL-10 受体。  |  Weber-Nordt, RM., et al. 1994. J Immunol. 153: 3734-44. PMID: 7930590
  12. 白细胞介素 10 的受体与干扰素受体有关。  |  Ho, AS., et al. 1993. Proc Natl Acad Sci U S A. 90: 11267-71. PMID: 8248239

订购信息

产品名称产品编号规格价格数量收藏夹

IL-10Rβ 抗体 (F-6)

sc-271969
200 µg/ml
RMB2377.00

IL-10Rβ (F-6): m-IgG Fc BP-HRP 套装

sc-529293
200 µg Ab; 10 µg BP
RMB2662.00

IL-10Rβ (F-6): m-IgGκ BP-HRP 套装

sc-522110
200 µg Ab, 40 µg BP
RMB2662.00

IL-10Rβ (F-6): m-IgG1 BP-HRP 套装

sc-543434
200 µg Ab; 20 µg BP
RMB2662.00

IL-10Rβ 抗体 (F-6) AC

sc-271969 AC
500 µg/ml, 25% agarose
RMB3129.00

IL-10Rβ 抗体 (F-6) HRP

sc-271969 HRP
200 µg/ml
RMB2377.00

IL-10Rβ 抗体 (F-6) FITC

sc-271969 FITC
200 µg/ml
RMB2482.00

IL-10Rβ 抗体 (F-6) PE

sc-271969 PE
200 µg/ml
RMB2580.00

IL-10Rβ 抗体 (F-6) Alexa Fluor® 488

sc-271969 AF488
200 µg/ml
RMB2685.00

IL-10Rβ 抗体 (F-6) Alexa Fluor® 546

sc-271969 AF546
200 µg/ml
RMB2685.00

IL-10Rβ 抗体 (F-6) Alexa Fluor® 594

sc-271969 AF594
200 µg/ml
RMB2685.00

IL-10Rβ 抗体 (F-6) Alexa Fluor® 647

sc-271969 AF647
200 µg/ml
RMB2685.00

IL-10Rβ 抗体 (F-6) Alexa Fluor® 680

sc-271969 AF680
200 µg/ml
RMB2685.00

IL-10Rβ 抗体 (F-6) Alexa Fluor® 790

sc-271969 AF790
200 µg/ml
RMB2685.00

IL-10Rβ (F-6) 中和勝肽

sc-271969 P
100 µg/0.5 ml
RMB511.00

Is it possible to detect also glycosylated forms of IL-10RB with this antibody?

Asked by: AS89
Thank you for your question. We have not specifically tested IL-10Rβ Antibody (F-6): sc-271969 to evaluate whether the antibody detects glycosylated forms of IL-10Rβ. This would have to be determined experimentally, using appropriate controls. For a limited time, we are offering a free 10 µg sample of this antibody. Please contact our Technical Service Department if you would like to request a sample for testing. Please call our European Support office toll-free at 00800 4573 8000, email [email protected], or contact us by live chat.
Answered by: Technical Support
Date published: 2017-03-27

What application is the blocking peptide sc-271969 P appropriate for?

Asked by: TinTin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 1 out of 5 by from Tested on HFFF by FACSThis antibody was tested on HFFF cells by FACS and did not give a signal, even at dilution 1:25
Date published: 2018-11-19
Rated 1 out of 5 by from Did not work for flow cytometryThe IL-10Rbeta antibody did not work for flow cytometry with HFF cells
Date published: 2018-11-01
Rated 5 out of 5 by from Excelente resultadoMe proporcionaron una muestra de este producto para probarlo y estamos encantados con el resultado
Date published: 2018-01-18
Rated 1 out of 5 by from Not suitable for IHCNot suitable for IHC in paraffin embedded human testis
Date published: 2017-09-01
Rated 5 out of 5 by from strong singal for WBDiluted the antibody 1:600 in 0.5% milk/TBST,some weak signals seen , however the presumably right band at around 37 kDa still the most prominent one.
Date published: 2017-07-29
Rated 5 out of 5 by from works wellThis antibody works well and can be used for IP with rat setoli cells.
Date published: 2017-06-03
Rated 5 out of 5 by from strong signalI tried this antibod in mouse heard mitochondria in WB, strong signal seen.
Date published: 2017-05-27
Rated 5 out of 5 by from recommend use itThe analysis results of Western blot were very strong and clear,I recommend use it.
Date published: 2017-02-24
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IL-10Rβ 抗体 (F-6) is rated 3.8 out of 5 by 10.
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