Date published: 2025-9-7

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IGSF11 抗体 (H-9): sc-393816

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说明书
  • IGSF11 抗体 H-9 是小鼠单克隆 IgG3 κ,IGSF11抗体, 在1篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的IGSF11的N-terminus附近的氨基酸21-38之间
  • 推荐用于 mouse, rat 和 human 来源的IGSF11 WB, IP, IF 和 ELISA检测
  • 关于如何获取IGSF11 (H-9): sc-393816免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG3 BP-HRP是IGSF11 Antibody (H-9) 适用于 WB 应用。 的首选辅助检测试剂,该试剂现与IGSF11 Antibody (H-9) 搭配使用(请参阅下面的订购信息)。

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関連項目

IGSF11抗体(H-9)是一种IgG3 κ小鼠单克隆IGSF11抗体(也称为IGSF11抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人源的IGSF11蛋白。IGSF11抗体(H-9)为非偶联抗IGSF11抗体。IGSF11(免疫球蛋白超家族成员11)也被称为BTIGSF(脑和睾丸特异性免疫球蛋白超家族蛋白)或VSIG3(含V-set和免疫球蛋白结构域的蛋白3),是一种由431个氨基酸组成的蛋白质,以三种异构体形式表达。IGSF11在睾丸和卵巢中高表达,也在脑、肾和骨骼肌中表达,作为单次跨膜蛋白定位于细胞膜上。IGSF11是一种具有V型和C2型结构域的免疫球蛋白,在分子识别中发挥作用。当IGSF11处于反式构象时,它通过与其他分子的同亲和性和异亲和性相互作用在细胞-细胞粘附中发挥重要作用。这些细胞-细胞相互作用也被认为对神经元细胞相互作用(如神经元-神经元或神经元-胶质细胞相互作用)非常重要,这对中枢神经系统的发育和功能至关重要。此外,IGSF11也可能参与支持细胞与精母细胞之间的相互作用,这是精子发生过程中的重要联系。IGSF11基因在胃癌中通常上调,IGSF11在许多类型的人类肿瘤中高表达,表明其可能作为免疫治疗的靶点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IGSF11 抗体 (H-9) 参考文献:

  1. 脑和睾丸优先表达的新型免疫球蛋白超家族基因的分子克隆。  |  Suzu, S., et al. 2002. Biochem Biophys Res Commun. 296: 1215-21. PMID: 12207903
  2. 在肠型胃癌中经常上调的 IGSF11 基因编码与 CXADR, FLJ22415 和 ESAM 同源的黏合剂分子。  |  Katoh, M. and Katoh, M. 2003. Int J Oncol. 23: 525-31. PMID: 12851705
  3. CLMP,CTX 家族的新成员和上皮细胞紧密连接的新成分。  |  Raschperger, E., et al. 2004. J Biol Chem. 279: 796-804. PMID: 14573622
  4. BT-IgSF 是一种新型免疫球蛋白超家族蛋白,具有细胞粘附分子的功能。  |  Harada, H., et al. 2005. J Cell Physiol. 204: 919-26. PMID: 15795899
  5. 将免疫球蛋白超家族 11 (IGSF11) 鉴定为胃肠癌和肝癌癌症免疫疗法的新靶点。  |  Watanabe, T., et al. 2005. Cancer Sci. 96: 498-506. PMID: 16108831

订购信息

产品名称产品编号规格价格数量收藏夹

IGSF11 抗体 (H-9)

sc-393816
200 µg/ml
RMB2377.00

IGSF11 (H-9): m-IgG3 BP-HRP 套装

sc-550599
200 µg Ab; 40 µg BP
RMB2662.00

IGSF11 (H-9) 中和勝肽

sc-393816 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-393816 P appropriate for?

Asked by: jenniferc
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
  • y_2025, m_8, d_29, h_8CST
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Rated 1 out of 5 by from Do not recognize purified Vsig3We have compared this antibody to another sourced antibody recognizing Vsig3. The Vsig3 antibody from Santa Cruz did not recognize recombinant pure Vsig3 on WB. Importantly, this antibody recognizes a protein on cells that does not correspond to a glycosylated form of Vsig3 (apparent mass was that of what would be a fully de-glycosylated Vsig3). The other sourced Vsig3 antibody did recognize by WB on the same cells, a protein band with the expected mass for glycosylated Vsig3. In summary, in our hands, the Santa Cruz Vsig3 antibody appears to recognize an unknown protein with a mass that is 20kD less than the expected mass of glycosylated Vsig3.
Date published: 2017-06-02
Rated 5 out of 5 by from Excellent immunofluorescence membrane stainingExcellent immunofluorescence membrane staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-04-29
Rated 5 out of 5 by from Produced positive Western Blot data of IGSF11Produced positive Western Blot data of IGSF11 expression in mouse kidney, human kidney and human skeletal muscle tissue extracts and NIH/3T3 and Jurkat whole cell lysates. -SCBT QC
Date published: 2014-12-15
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IGSF11 抗体 (H-9) is rated 3.7 out of 5 by 3.
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