Date published: 2025-9-6

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IGFBP2 抗体 (G-4): sc-515134

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说明书
  • IGFBP2抗体(G-4)是小鼠单克隆IgG1 κ, 在3篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于mouse物种的IGFBP2的C-terminus的氨基酸284-305之间
  • 抗-IGFBP2 抗体 (G-4) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse 和rat 来源的 precursor and mature IGFBP2
  • 抗IGFBP2抗体(G-4)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取IGFBP2 (G-4): sc-515134免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 IGFBP2 抗体 (G-4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与IGFBP2 抗体 (G-4) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

IGFBP2抗体(G-4)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过应用诸如蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组织化学(IHCP)和酶联免疫吸附测定(ELISA)等方法检测小鼠和大鼠样本中的IGFBP2。IGFBP2 (G-4) 抗体有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。胰岛素样生长因子结合蛋白(IGFBPs)是IGF信号系统的重要调节因子,而IGFBP2作为将生长因子运送到目标组织的伴侣蛋白,在调节IGF生物利用度方面发挥着重要作用。这种运输功能确保IGFs以可控的方式发挥生物学效应,影响细胞生长、分化和新陈代谢等过程。IGFBP2在包括胎儿眼睛和胎儿大脑在内的多种人体组织中表达,凸显了其在发育中的重要性。IGFBP2与IGFs的相互作用会影响它们在细胞外环境中的浓度和分布,进一步强调了其调节意义。了解IGFBP2的动态变化和IGFs的相互作用对于阐明生长因子信号传导的复杂性以及其在健康和疾病中的意义至关重要。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IGFBP2 抗体 (G-4) 参考文献:

  1. IGFBP2调节食管腺癌的耐药表型。  |  Myers, AL., et al. 2015. Oncotarget. 6: 25897-916. PMID: 26317790
  2. IGFBP2促进神经干细胞的维持和增殖,与胶质母细胞瘤亚型有关。  |  Shen, F., et al. 2019. Brain Res. 1704: 174-186. PMID: 30347220
  3. IGFBP2在早期认知发展中起着至关重要的作用。  |  Khan, S., et al. 2019. Adv Sci (Weinh). 6: 1901152. PMID: 31832311
  4. IGFBP2通过调节E-cadherin表达促进结直肠癌细胞的EMT。  |  Zhu, H., et al. 2019. Int J Clin Exp Pathol. 12: 2559-2565. PMID: 31934083
  5. 转移性结直肠癌相关成纤维细胞具有免疫抑制特性,与IGFBP2表达增加有关。  |  Walterskirchen, N., et al. 2022. Cancer Lett. 540: 215737. PMID: 35569697
  6. IGFBP2 通过 STAT3/IDO 信号通路驱动胰腺癌调节性 T 细胞分化  |  Sun, L., et al. 2022. J Pers Med. 12: PMID: 36556226
  7. IGFBP2通过STAT3信号传导促进Sonic hedgehog髓母细胞瘤的增殖和细胞迁移。  |  Kunhiraman, H., et al. 2023. Acta Neuropathol Commun. 11: 62. PMID: 37029430
  8. 鹅肝IGFBP2受营养状况调节,主要通过细胞因子-细胞因子受体途径参与能量代谢。  |  Li, F., et al. 2023. Animals (Basel). 13: PMID: 37508113
  9. 一种新型AML1-ETO/FTO正反馈回路通过稳定t(8;21)急性髓细胞白血病中的IGFBP2来促进白血病发生和Ara-C耐药性。  |  Zhou, W., et al. 2024. Exp Hematol Oncol. 13: 9. PMID: 38268050
  10. 循环IGFBP2在胰腺癌中的预后和诊断价值。  |  Xu, J., et al. 2024. Open Med (Wars). 19: 20230893. PMID: 39221034

订购信息

产品名称产品编号规格价格数量收藏夹

IGFBP2 抗体 (G-4)

sc-515134
200 µg/ml
RMB2377.00

IGFBP2 (G-4): m-IgG Fc BP-HRP 套装

sc-531295
200 µg Ab; 10 µg BP
RMB2662.00

IGFBP2 (G-4): m-IgGκ BP-HRP 套装

sc-524949
200 µg Ab, 40 µg BP
RMB2662.00

IGFBP2 (G-4): m-IgG1 BP-HRP 套装

sc-544472
200 µg Ab; 20 µg BP
RMB2662.00

IGFBP2 抗体 (G-4) AC

sc-515134 AC
500 µg/ml, 25% agarose
RMB3129.00

IGFBP2 抗体 (G-4) HRP

sc-515134 HRP
200 µg/ml
RMB2377.00

IGFBP2 抗体 (G-4) FITC

sc-515134 FITC
200 µg/ml
RMB2482.00

IGFBP2 抗体 (G-4) PE

sc-515134 PE
200 µg/ml
RMB2580.00

IGFBP2 抗体 (G-4) Alexa Fluor® 488

sc-515134 AF488
200 µg/ml
RMB2685.00

IGFBP2 抗体 (G-4) Alexa Fluor® 546

sc-515134 AF546
200 µg/ml
RMB2685.00

IGFBP2 抗体 (G-4) Alexa Fluor® 594

sc-515134 AF594
200 µg/ml
RMB2685.00

IGFBP2 抗体 (G-4) Alexa Fluor® 647

sc-515134 AF647
200 µg/ml
RMB2685.00

IGFBP2 抗体 (G-4) Alexa Fluor® 680

sc-515134 AF680
200 µg/ml
RMB2685.00

IGFBP2 抗体 (G-4) Alexa Fluor® 790

sc-515134 AF790
200 µg/ml
RMB2685.00

IGFBP2 (G-4) 中和勝肽

sc-515134 P
100 µg/0.5 ml
RMB511.00

What is the optimal concentration of IGFBP2 (G-4) antibody for immunofluorescence staining on frozen sections?

Asked by: Book
Thank you for your question. The recommended dilution ratio is 1:50 to 1:500, starting dilution 1:50. If you have any other question, please contact our Technical Service Department. Our Asian Technical Service team is available at (+86) 021-60936350 or [email protected] or by live chat on our website.
Answered by: Sen Li
Date published: 2025-08-07

What application is the blocking peptide sc-515134 P appropriate for?

Asked by: TinTin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Nice specificityI used it to detect endometrial cells growing on the colorectal tissue in endometriosis biopsies.
Date published: 2023-07-04
Rated 3 out of 5 by from primary hepatocytes - western blot analysisThis antibody detected Igfbp2 below the 37kDa marker band in whole cell lysates of primary hepatocytes from C57Bl6 mice. Unfortunately a second (unspecific) band appered above the Igfbp2 band in all lysates tested. A dilution of 1:500 in 5% milk powder in TBS-T was used. Secondary anti-mouse antibody was diluted 1:1000.
Date published: 2018-03-22
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IGFBP2 抗体 (G-4) is rated 4.0 out of 5 by 2.
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