Date published: 2025-9-6

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IFN-αR1 抗体 (MAR1-5A3): sc-53591

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说明书
  • IFN- alpha R1 抗体 MAR1-5A3 是小鼠单克隆 IgG1 κ,IFN-αR1抗体, 在5篇文献中引用,规格为200 µg/ml
  • 针对IFN-αR1的胞外结构域,源自mouse
  • IFN- alpha R1 抗体 (MAR1-5A3) 推荐用于WB, IP, IF, IHC(P) 和 FCM,检测mouse 来源的 IFN-αR1
  • 抗IFN- alpha R1抗体(MAR1-5A3)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 还提供无叠氮化物的中和剂,sc-53591 L,200 µg/0.1 ml
  • 关于如何获取IFN-αR1 (MAR1-5A3): sc-53591免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 IFN-αR1 抗体 (MAR1-5A3) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与IFN-αR1 抗体 (MAR1-5A3) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

IFN-αR1 抗体(MAR1-5A3)是一种小鼠单克隆 IgG1 kappa 轻链抗体,可通过免疫印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组织化学(IHCP)和流式细胞术(FCM)检测小鼠 IFN-αR1 蛋白。抗 IFN-αR1 抗体 (MAR1-5A3) 有非共轭型和多种共轭型,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 共轭物。IFN-αR1 作为 I 型干扰素的受体,在免疫反应中发挥着至关重要的作用,而 I 型干扰素对于介导抗病毒活性和调节免疫反应至关重要。具体来说,IFN-αR1 参与了干扰素-α 和干扰素-β 的结合和信号传导,而干扰素-α 和干扰素-β 对于激活免疫细胞和在组织中建立抗病毒状态至关重要。IFN-αR1 与细胞质酪氨酸激酶 JAK1 的相互作用能力尤为重要,因为这种相互作用促进了下游信号通路,导致干扰素刺激基因的表达,从而增强宿主对病毒感染的防御能力。此外,IFN-αR1 还存在剪接变体,如 IFN-αR1a,这凸显了其在不同细胞环境中调控和功能的复杂性。IFN-αR1 单克隆抗体(MAR1-5A3)是研究人员研究免疫信号转导机制和干扰素在疾病中作用的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IFN-αR1 抗体 (MAR1-5A3) 参考文献:

  1. 人类干扰素-γ 受体。抗体的纯化, 表征和制备。  |  Novick, D., et al. 1987. J Biol Chem. 262: 8483-7. PMID: 2954953
  2. 人类干扰素-γ 受体的分子克隆和表达。  |  Aguet, M., et al. 1988. Cell. 55: 273-80. PMID: 2971451
  3. I 型和 II 型干扰素受体。  |  Orchansky, P., et al. 1984. J Interferon Res. 4: 275-82. PMID: 6086780
  4. 有证据表明 I 型和 II 型干扰素具有不同的受体。  |  Branca, AA. and Baglioni, C. 1981. Nature. 294: 768-70. PMID: 6172715
  5. 鉴定激活人类干扰素γ受体所需的辅助因子及其序列。  |  Soh, J., et al. 1994. Cell. 76: 793-802. PMID: 8124716
  6. 干扰素受体家族的一个新成员补充了鼠干扰素γ受体在人体细胞中的功能。  |  Hemmi, S., et al. 1994. Cell. 76: 803-10. PMID: 8124717
  7. 人类干扰素α/β受体:特征描述和分子克隆。  |  Novick, D., et al. 1994. Cell. 77: 391-400. PMID: 8181059

订购信息

产品名称产品编号规格价格数量收藏夹

IFN-αR1 抗体 (MAR1-5A3)

sc-53591
200 µg/ml
$316.00

IFN-αR1 (MAR1-5A3): m-IgG Fc BP-HRP 套装

sc-526831
200 µg Ab; 10 µg BP
$354.00

IFN-αR1 (MAR1-5A3): m-IgG1 BP-HRP 套装

sc-532204
200 µg Ab; 20 µg BP
$354.00

IFN-αR1 抗体 (MAR1-5A3) L

sc-53591 L
200 µg/0.1 ml
$316.00

IFN-αR1 抗体 (MAR1-5A3) AC

sc-53591 AC
500 µg/ml, 25% agarose
$416.00

IFN-αR1 抗体 (MAR1-5A3) HRP

sc-53591 HRP
200 µg/ml
$316.00

IFN-αR1 抗体 (MAR1-5A3) FITC

sc-53591 FITC
200 µg/ml
$330.00

IFN-αR1 抗体 (MAR1-5A3) PE

sc-53591 PE
200 µg/ml
$343.00

IFN-αR1 抗体 (MAR1-5A3) Alexa Fluor® 488

sc-53591 AF488
200 µg/ml
$357.00

IFN-αR1 抗体 (MAR1-5A3) Alexa Fluor® 546

sc-53591 AF546
200 µg/ml
$357.00

IFN-αR1 抗体 (MAR1-5A3) Alexa Fluor® 594

sc-53591 AF594
200 µg/ml
$357.00

IFN-αR1 抗体 (MAR1-5A3) Alexa Fluor® 647

sc-53591 AF647
200 µg/ml
$357.00

IFN-αR1 抗体 (MAR1-5A3) Alexa Fluor® 680

sc-53591 AF680
200 µg/ml
$357.00

IFN-αR1 抗体 (MAR1-5A3) Alexa Fluor® 790

sc-53591 AF790
200 µg/ml
$357.00

Dear Sirs. I kindly ask for the sequence of the MAR1-5A3 antibody, if public. Many thanks in advance for your support Best Regards, Piera

Asked by: piera
Thank you for your question. IFN-αR1 Antibody (MAR1-5A3): sc-53591 was raised against the extracellular domain of IFN-αR1 of mouse origin. We have not performed epitope mapping on this product, so we do not have information on its exact binding site.
Answered by: Tech Support Europe
Date published: 2025-04-08

Can IFN-αR1 (MAR1-5A3): sc-53591 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Randy McDonald
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, IFN-αR1 (MAR1-5A3): sc-53591 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-03-01
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Rated 2 out of 5 by from Tested on HFFF by FACSThis antibody was tested on HFFF cells by FACS and did not show a signal, even at dilution 1:25. Therefore, it does not cross react with human IFN-aR1
Date published: 2018-11-16
Rated 5 out of 5 by from Excellent!This antibody is recommended for detection of IFN-αR1 of mouse origin by WB, IP and FCM.
Date published: 2017-01-26
Rated 5 out of 5 by from IFN-alpha R1,perfect.I useanti- IFN-alpha R1 to study the expression of IFN-alpha R on NK cells,T cells in FCM.The result is perfect.
Date published: 2016-11-20
Rated 4 out of 5 by from This antibody was used in a publication forThis antibody was used in a publication for WB on human RD and SK-N-SH cells - SCBT Publication Review
Date published: 2015-02-16
Rated 4 out of 5 by from FACS publishable data with mouse germ cellsFACS publishable data with mouse germ cells - SCBT Publication Review
Date published: 2014-01-30
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IFN-αR1 抗体 (MAR1-5A3) is rated 4.0 out of 5 by 5.
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