Date published: 2025-9-7

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ICK 抗体 (G-8): sc-365244

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说明书
  • ICK 抗体 G-8 是小鼠单克隆 IgM (kappa轻链),ICK抗体,规格为200 µg/ml
  • 特异性抗原位于mouse物种的ICK的C-terminus附近的氨基酸579-611之间
  • 推荐用于 mouse, rat 和 human 来源的ICK WB, IP, IF, IHC(P) 和 ELISA检测; 也和以下物种反应,包括: 和 equine, canine, bovine and porcine
  • 关于如何获取ICK (G-8): sc-365244免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP 是 ICK 抗体 (G-8) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与ICK 抗体 (G-8) 组合成套装提供。 (请参阅下面的订购信息)。其他m-IgGκ BP 偶联产品,请参阅我们的小鼠 IgG 结合蛋白完整列表。

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    関連項目

    ICK抗体(G-8)是一种IgM κ小鼠单克隆ICK抗体(也称为ICK抗体),可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人源的ICK蛋白。ICK抗体(G-8)为非偶联抗ICK抗体。肠细胞激酶(ICK),也被称为MRK、LCK2、KIAA0936和MGC46090,是一种核Cdc2相关激酶。ICK与男性生殖细胞相关激酶(MAK)的N端催化结构域几乎完全相同,但肠细胞激酶的C端非催化结构域与MAK不同。ICK的催化结构域也与丝裂原活化蛋白激酶(MAPKs)相关,并具有相应的TDY模序,其双重磷酸化可激活ICK。TDY模序中Tyr 159的磷酸化需要ICK自激酶活性,但仅赋予基础激酶活性;该蛋白的完全激活需要TDY模序中Thr 157的额外磷酸化。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    ICK 抗体 (G-8) 参考文献:

    1. 肠细胞激酶(ICK)定域于隐窝区,需要一个在图谱激酶中发现的双重磷酸化位点。  |  Togawa, K., et al. 2000. J Cell Physiol. 183: 129-39. PMID: 10699974
    2. 人类外周血淋巴细胞中 GM3 与 CD4-Ick 复合物之间的关联。  |  Sorice, M., et al. 2000. Glycoconj J. 17: 247-52. PMID: 11201797
    3. 一种抗 CD20-IL-2 免疫细胞因子对已确诊人类 B 淋巴瘤的 SCID 小鼠模型疗效显著。  |  Gillies, SD., et al. 2005. Blood. 105: 3972-8. PMID: 15692062
    4. 通过自身磷酸化和细胞周期蛋白依赖性蛋白激酶激活激酶,激活丝裂原活化蛋白激酶样 TDY 矩阵内的核 Cdc2 相关激酶。  |  Fu, Z., et al. 2005. Mol Cell Biol. 25: 6047-64. PMID: 15988018
    5. 幼年肌阵挛性癫痫患者 6p12-p11 上基因的突变分析。  |  Suzuki, T., et al. 2006. Neurosci Lett. 405: 126-31. PMID: 16876319
    6. Ick 蛋白酪氨酸激酶并不参与抗体介导的 CD4(CDR3-环)信号转导,从而抑制 HIV-1 的转录。  |  Coudronnière, N., et al. 1998. Eur J Immunol. 28: 1445-57. PMID: 9603449

    订购信息

    产品名称产品编号规格价格数量收藏夹

    ICK 抗体 (G-8)

    sc-365244
    200 µg/ml
    $316.00

    ICK (G-8): m-IgGκ BP-HRP 套装

    sc-522176
    200 µg Ab, 40 µg BP
    $354.00

    ICK (G-8) 中和勝肽

    sc-365244 P
    100 µg/0.5 ml
    $68.00

    What application is the blocking peptide sc-365244 P appropriate for?

    Asked by: Professor Griffin
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 5 out of 5 by from Excellent results obtained by Western blot.This antibody could be used without BSA or milk powder. It is sufficient to dilute it 1:1000 in TBST and incubate membrane for 1 hour at room temperature with moderate agitation.
    Date published: 2016-12-17
    Rated 5 out of 5 by from Excellent antibody for Western blotting.This product has been independently tested and validated in-house at Kinexus Bioinformatics Corporation as a very potent and highly specific antibody for Western blotting with a mixture of mouse brain, testes and thymus tissue lysates. In immunoblots, tt very strongly detects a protein of about 60 kDa, which is lower than the predicted molecular mass of 71 kDa.
    Date published: 2016-10-13
    Rated 5 out of 5 by from Excellent immunoperoxidase cytoplasmic stainingExcellent immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human colon tissue. -SCBT QC
    Date published: 2015-05-02
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    ICK 抗体 (G-8) is rated 5.0 out of 5 by 4.
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