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ICAM-2 抗体 (CBR-IC2/2): sc-23935

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说明书
  • ICAM-2抗体(CBR-IC2/2)是小鼠单克隆IgG2a κ, 在3篇文献中引用,规格为200 µg/ml
  • 针对转染了重组human的细胞 ICAM-2
  • 推荐用于 human 来源的ICAM-2 WB, IP, IF 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是ICAM-2 Antibody (CBR-IC2/2) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与ICAM-2 Antibody (CBR-IC2/2) 打包提供(请参阅下面的订购信息)。

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関連項目

细胞粘附分子是一组密切相关的细胞表面糖蛋白,它们参与生长过程中的细胞间相互作用,并被认为在胚胎发生和发育中发挥着重要且独立的作用。细胞内粘附分子-1(ICAM-1),也被称为CD54,是免疫球蛋白超家族的一种整体膜蛋白,能识别β2α1和β2αM整合素。ICAM-2作为淋巴细胞功能相关抗原-1(LFA-1)的配体,参与白细胞粘附。ICAM-3在人类嗜酸性粒细胞表面高度表达,与配体结合可能抑制嗜酸性粒细胞的炎症反应和存活。ICAM-4,也被称为LW糖蛋白,与整合素αLβ2、αMβ2、α4β1、αV家族和αIIbβ3相互作用,选择性结合不同的整合素可能与多种红细胞相关疾病的病理有关。最后,在端脑神经元上表达的ICAM-5与CD11α/CD18结合,因此可能在中枢神经系统中作为白细胞结合的粘附分子。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ICAM-2 抗体 (CBR-IC2/2) 参考文献:

  1. T细胞的共刺激作用可产生不同的IL-10和TNF-α细胞因子谱,具体取决于与ICAM-1、ICAM-2或ICAM-3的结合。  |  Bleijs, DA., et al. 1999. Eur J Immunol. 29: 2248-58. PMID: 10427988
  2. 血小板上 ICAM-2 的硅烷基化会影响白细胞通过 LFA-1 和 DC-SIGN 的粘附。  |  Weber, KS., et al. 2004. Inflammation. 28: 177-88. PMID: 15673159
  3. 特发性肺纤维化患者血清中的ICAM-1、ICAM-2和ICAM-3。  |  Tsoutsou, PG., et al. 2004. Inflammation. 28: 359-64. PMID: 16245079
  4. 抑制ICAM2可诱导口腔鳞状细胞癌细胞对放射线敏感。  |  Ishigami, T., et al. 2008. Br J Cancer. 98: 1357-65. PMID: 18349842
  5. 上皮细胞ICAM-1和ICAM-2调节人类T细胞穿过支气管上皮。  |  Porter, JC. and Hall, A. 2009. FASEB J. 23: 492-502. PMID: 18842965
  6. ICAM-2通过ezrin-radixin-moesin(ERM)蛋白和Rac-1信号传导调节血管通透性和N-cadherin定位。  |  Amsellem, V., et al. 2014. Cell Commun Signal. 12: 12. PMID: 24593809
  7. ICAM-2通过与α-肌动蛋白相互作用,赋予神经母细胞瘤细胞非转移表型。  |  Feduska, JM., et al. 2015. Oncogene. 34: 1553-62. PMID: 24704826
  8. 麻风病中的内皮粘附分子ICAM-1、ICAM-2、VCAM-1和VLA-4表达。  |  de Sousa, J., et al. 2017. Microb Pathog. 104: 116-124. PMID: 28088473
  9. ICAM2在转移性三阴性乳腺癌的软脑膜转移中启动跨血脑脊液屏障迁移和干细胞特性。  |  Pan, JK., et al. 2023. Oncogene. 42: 2919-2931. PMID: 37620448
  10. ICAM-1 和 ICAM-2 以及 CD11/CD18 交替配体在中性粒细胞跨内皮迁移中的作用。  |  Issekutz, AC., et al. 1999. J Leukoc Biol. 65: 117-26. PMID: 9886254

订购信息

产品名称产品编号规格价格数量收藏夹

ICAM-2 抗体 (CBR-IC2/2)

sc-23935
200 µg/ml
RMB2377.00

ICAM-2 (CBR-IC2/2): m-IgG Fc BP-HRP 套装

sc-536690
200 µg Ab; 10 µg BP
RMB2662.00

ICAM-2 (CBR-IC2/2): m-IgGκ BP-HRP 套装

sc-533850
200 µg Ab; 40 µg BP
RMB2662.00

ICAM-2 (CBR-IC2/2): m-IgG2a BP-HRP 套装

sc-547846
200 µg Ab; 10 µg BP
RMB2662.00

ICAM-2 抗体 (CBR-IC2/2) FITC

sc-23935 FITC
200 µg/ml
RMB2482.00

ICAM-2 抗体 (CBR-IC2/2) PE

sc-23935 PE
200 µg/ml
RMB2580.00

How can ICAM-2 (CBR-IC2/2): sc-23935 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: Professor Griffin
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to phycoerythrin (sc-23935 PE) or fluoroscein (sc-23935 FITC).
Answered by: Technical Support
Date published: 2017-02-27
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Rated 4 out of 5 by from Strong pulldown in IP in HLStrong pulldown in IP in HL-60 whole cell lysate. -SCBT QC
Date published: 2015-04-11
Rated 4 out of 5 by from Good publishable data in WB and IP in human HUVECsGood publishable data in WB and IP in human HUVECs. -SCBT Publication Review
Date published: 2015-03-02
Rated 4 out of 5 by from Produced great FCM data for human peripheralProduced great FCM data for human peripheral blood leukocytes. -SCBT QC
Date published: 2014-01-24
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ICAM-2 抗体 (CBR-IC2/2) is rated 4.0 out of 5 by 3.
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