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HTLV-1 Tax 抗体 (1A3): sc-57872

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说明书
  • HTLV-1 Tax 抗体 1A3 是小鼠单克隆 IgG2a，HTLV-1 Tax抗体, 在14篇文献中引用，规格为50 µg/500 µl
  • 全长抗原 HTLV-1 Tax
  • 推荐用于WB, IF, IHC(P)和ELISA检测HTLV-1
  • 关于如何获取HTLV-1 Tax (1A3): sc-57872的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG2a BP-HRP 是 HTLV-1 Tax 抗体 (1A3) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与HTLV-1 Tax 抗体 (1A3) 组合成套装提供。 (请参阅下面的订购信息)。

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研究信息

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此外 HTLV-1 抗体包括 HTLV-1 gp46, HTLV-1 p19, HTLV-1 p24 和 HTLV-1 Tax

HTLV-1 Tax 抗体 (1A3) 是一种 IgG2a 小鼠单克隆 HTLV-1 Tax 抗体（也称为 HTLV-1 Tax 抗体），可通过 WB、IF、IHC(P) 和 ELISA 检测 HTLV-1 起源的 HTLV-1 Tax 蛋白。HTLV-1 Tax 抗体 (1A3) 作为非偶联抗 HTLV-1 Tax 抗体提供。HTLV-1 导致两种不同的人类疾病，HTLV-1 相关脊髓病/热带痉挛性瘫痪 (HAM/TSP) 和成人 T 细胞白血病/淋巴瘤 (ATL)。HTLV-1 env 基因编码的糖蛋白对于与靶细胞表面未鉴定受体的相互作用至关重要，并在感染过程中起关键作用。由 HTLV-1 Tax 编码的磷酸化癌蛋白起着转录激活剂的作用。Tax 能够调节许多细胞基因的表达和功能，对于理解 HTLV-1 介导的细胞转化至关重要。在激活细胞基因表达时，Tax 会影响多个细胞信号转导通路，包括 CREB/ATF 和 NFkB 通路。此外，Tax 会下调下游基因的表达，这些基因介导细胞周期控制。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

HTLV-1 Tax 抗体 (1A3) 参考文献:

  1. 源自 gp21 跨膜糖蛋白外端域的合成肽在结合后阶段抑制无细胞的人类 T 细胞白血病病毒 1 型感染。  |  Jinno, A., et al. 1999. J Virol. 73: 9683-9. PMID: 10516085
  2. HTLV 1 型表面包膜糖蛋白的氨基端和羧基端的序列变异可诱导特异性中和抗体。  |  Tallet, B., et al. 2001. AIDS Res Hum Retroviruses. 17: 337-48. PMID: 11242520
  3. 人类 T 细胞白血病病毒 I 型 Tax 致癌蛋白的功能活动：通过 NF-kappa B 发出细胞信号。  |  Jeang, KT. 2001. Cytokine Growth Factor Rev. 12: 207-17. PMID: 11325603
  4. 税转化蛋白对 NF-kappa B 的持续激活涉及 IkappaB 激酶亚基 IKKbeta 和 IKKgamma 的慢性磷酸化。  |  Carter, RS., et al. 2001. J Biol Chem. 276: 24445-8. PMID: 11325957
  5. 通过泛素-蛋白酶体途径调节HTLV-1 tax稳定性、细胞运输和NF-κB激活。  |  Lavorgna, A. and Harhaj, EW. 2014. Viruses. 6: 3925-43. PMID: 25341660
  6. 将 HTLV-1 Tax 蛋白招募到 IKKε 和 TBK1 激酶复合物中可增强 IFN-I 的表达。  |  Diani, E., et al. 2015. Virology. 476: 92-99. PMID: 25531185
  7. 由HTLV-1 Tax和HBZ介导的NF-κB和MicroRNA失调。  |  Fochi, S., et al. 2019. Pathogens. 8: PMID: 31835460
  8. HTLV-1相关性脊髓病/热带痉挛性截瘫患者中HTLV-1 Tax反应元件的多态性与病毒前体载量降低有关，但与疾病进展无关。  |  Gomes, YCP., et al. 2021. J Gen Virol. 102: PMID: 34494950
  9. 侵袭性T细胞白血病/淋巴瘤长期存活者的HTLV-1 Tax特异性记忆细胞毒性T淋巴细胞。  |  Jo, T., et al. 2022. Cancer Med. 11: 3238-3250. PMID: 35315593
  10. 选择性 APC 靶向新型 Fc 融合多免疫显性重组蛋白（tTax-tEnv:mFcγ2a）以开发 HTLV-1 疫苗。  |  Shafifar, M., et al. 2022. Life Sci. 308: 120920. PMID: 36044973
  11. PCBP1与HTLV-1 Tax致癌蛋白相互作用，增强NF-κB的活性。  |  Su, R., et al. 2024. Front Immunol. 15: 1375168. PMID: 38690287
  12. 人类 CD4+ T 淋巴细胞能识别受 HLA DRB1*0101 限制的高度保守的人类 T 淋巴细胞病毒 1 型（HTLV-1） env gp21 表位。  |  Kitze, B., et al. 1998. Clin Exp Immunol. 111: 278-85. PMID: 9486393

订购信息

产品名称产品编号规格价格数量收藏夹

HTLV-1 Tax 抗体 (1A3)

sc-57872
50 µg/500 µl
RMB2504.00

HTLV-1 Tax (1A3): m-IgG Fc BP-HRP 套装

sc-539071
50 µg Ab; 10 µg BP
RMB2662.00

HTLV-1 Tax (1A3): m-IgG2a BP-HRP 套装

sc-546663
50 µg Ab; 10 µg BP
RMB2662.00

Hello, have you ever tested this antibody for confocal microscopy staining? Thanks in advance. Kind regards,

Asked by: clementheymann
Thank you for your question. HTLV-1 Tax Antibody (1A3): sc-57872 is recommended for detection of HTLV-1 by WB, IF, IHC(P) and ELISA and can be used in fluorescence-based microscopy.
Answered by: Tech Support Europe
Date published: 2024-08-26

Bonjour, Pourriez-vous me dire à quel pH avez-vous fait le démasquage svp pour IHC(P)? merci d'avance

Asked by: Anonymous
Thank you for your question. For antigen retrieval we recommend Heat treatment: Place slides in a container and cover with 10 mM sodium citrate buffer, pH 6.0 (sc-294091); or with 50 mM glycine-HCl buffer (sc-29096), pH 3.5, with 0.01% (w/v) EDTA (sc-29092). Heat at 95° C for 5 minutes. Top off with fresh buffer and heat at 95° C for 5 minutes (optimal incubation time may vary for each tissue type). Allow slides to cool in the buffer for approximately 20 minutes. Wash in deionized H2O three times for 2 minutes each. Aspirate excess liquid from slides.
Answered by: Tech Support Europe
Date published: 2024-08-08

I'm working with a mutant Tax we generated. Do you have information on the eptiope this antibody recognizes

Asked by: Dillon305
Thank you for your question. The exact epitope recognized by this mouse monoclonal antibody has not yet been determined.
Answered by: Technical Support
Date published: 2019-01-26

I would like to ask you about the posibility to send me a very small sample of HTLV-1 TAX monoclonal antibody (HTLV-1 Tax Antibody (1A3): sc-57872 ) to test it in my laboratory?

Asked by: Anetas
Thank you very much for your inquiry and interest in our products. Unfortunately, we don't offer samples for this antibody, however if you decide to purchase it, please remember we offer a product warranty valid for one year since the date of purchase (on the recommended application/species), which means that we would offer you a cost-free replacement (for example a different antibody lot or another antibody) should the antibody not perform as described in our product literature.
Answered by: Tech Service
Date published: 2017-03-17

Can this antibody be used in IHC with paraffin-embedded samples?

Asked by: TinTin
Thank you for your question. Yes, this HTLV-1 Tax (1A3): sc-57872 monoclonal antibody is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support 10
Date published: 2017-01-17
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Rated 3 out of 5 by from Efficace mais ...efficace seulement pour une utilisation. La sauce est au 1/1000e et n'a fonctionné qu'une seule fois
Date published: 2018-02-09
Rated 5 out of 5 by from Good Antibody for WBHTLV-1 Tax (1A3) is cited for Western blot (WB) in various scientific journals.
Date published: 2017-01-23
Rated 4 out of 5 by from This antibody was used in a publication forThis antibody was used in a publication for WB on human embryonic kidney (HEK) 293, HEK293T cells - SCBT Publication Review
Date published: 2014-07-26
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HTLV-1 Tax 抗体 (1A3) is rated 4.0 out of 5 by 3.
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