Date published: 2025-9-11

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HSV-1 ICP0 抗体 (11060): sc-53070

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说明书
  • HSV-1 ICP0 抗体 11060 是小鼠单克隆 IgG2b κ,HSV-1 ICP0抗体, 在65篇文献中引用,规格为200 µg/ml
  • 针对重组Vmw110蛋白,在氨基酸20-105内进行表位图谱分析
  • HSV-1 ICP0 抗体 (11060) 推荐用于WB, IP 和 IF,检测viral 来源的 HSV-1 ICP0
  • 抗HSV-1 ICP0抗体(11060)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取HSV-1 ICP0 (11060): sc-53070免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP2b BP-HRP">m-IgG2b BP-HRP是HSV-1 ICP0 Antibody (11060) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与HSV-1 ICP0 Antibody (11060) 打包提供(请参阅下面的订购信息)。

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関連項目

HSV-1 ICP0抗体(11060)是一种小鼠单克隆IgG2b kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)和免疫荧光(IF)检测病毒来源的HSV-1 ICP0蛋白。HSV-1 ICP0 (11060) 抗体有非结合型和多种结合型可供选择,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。感染细胞蛋白0(ICP0)作为所有三类单纯疱疹病毒(HSV)基因的通用转激活因子发挥着至关重要的作用,对于病毒的复制和感染至关重要。ICP0对于克服宿主的抗病毒防御至关重要,因为它会破坏人类BHC共抑制复合物,从而防止病毒DNA沉默。这一功能尤为重要,因为ICP0能够使病毒从潜伏状态中重新激活并转变为裂解状态,从而促进病毒基因的表达和复制。此外,ICP0与人类中心粒蛋白CENP-A相互作用,导致CENP-A降解,这进一步强调了ICP0在操纵宿主细胞机制以促进病毒繁殖方面的作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

HSV-1 ICP0 抗体 (11060) 参考文献:

  1. 由单纯疱疹病毒 1 型蛋白 ICP0 诱导的核糖体缔合作用中心粒组蛋白 H3 样蛋白 CENP-A 的降解。  |  Lomonte, P., et al. 2001. J Biol Chem. 276: 5829-35. PMID: 11053442
  2. 在受 HSV-1 感染的细胞中,REST/CoREST/组蛋白去乙酰化酶抑制复合物的成分发生了破坏, 改变和易位。  |  Gu, H., et al. 2005. Proc Natl Acad Sci U S A. 102: 7571-6. PMID: 15897453
  3. ICP0 和单纯疱疹病毒 1 的 US3 蛋白激酶可独立阻断组蛋白去乙酰化,使基因得以表达。  |  Poon, AP., et al. 2006. Proc Natl Acad Sci U S A. 103: 9993-8. PMID: 16785443
  4. 1 型单纯疱疹病毒潜伏感染的神经元不同程度地表达潜伏期缔合作用和 ICP0 转录本。  |  Maillet, S., et al. 2006. J Virol. 80: 9310-21. PMID: 16940542
  5. 单纯疱疹病毒 1 型 ICP0 定位于受感染兔角膜的基质层,主要分布在兔角膜细胞的细胞质和/或核周区域。  |  Morishige, N., et al. 2006. J Gen Virol. 87: 2817-2825. PMID: 16963739
  6. ICP22 是野生型 1 型单纯疱疹病毒病毒组成和感染性所必需的。  |  Orlando, JS., et al. 2006. J Virol. 80: 9381-90. PMID: 16973544
  7. 1 型单纯疱疹病毒 IE110 基因的特征。  |  Perry, LJ., et al. 1986. J Gen Virol. 67 (Pt 11): 2365-80. PMID: 3023529

订购信息

产品名称产品编号规格价格数量收藏夹

HSV-1 ICP0 抗体 (11060)

sc-53070
200 µg/ml
RMB2377.00

HSV-1 ICP0 (11060): m-IgG Fc BP-HRP 套装

sc-525573
200 µg Ab; 10 µg BP
RMB2662.00

HSV-1 ICP0 (11060): m-IgG2b BP-HRP 套装

sc-549587
200 µg Ab; 10 µg BP
RMB2662.00

HSV-1 ICP0 抗体 (11060) AC

sc-53070 AC
500 µg/ml, 25% agarose
RMB3129.00

HSV-1 ICP0 抗体 (11060) HRP

sc-53070 HRP
200 µg/ml
RMB2377.00

HSV-1 ICP0 抗体 (11060) FITC

sc-53070 FITC
200 µg/ml
RMB2482.00

HSV-1 ICP0 抗体 (11060) PE

sc-53070 PE
200 µg/ml
RMB2580.00

HSV-1 ICP0 抗体 (11060) Alexa Fluor® 488

sc-53070 AF488
200 µg/ml
RMB2685.00

HSV-1 ICP0 抗体 (11060) Alexa Fluor® 546

sc-53070 AF546
200 µg/ml
RMB2685.00

HSV-1 ICP0 抗体 (11060) Alexa Fluor® 594

sc-53070 AF594
200 µg/ml
RMB2685.00

HSV-1 ICP0 抗体 (11060) Alexa Fluor® 647

sc-53070 AF647
200 µg/ml
RMB2685.00

HSV-1 ICP0 抗体 (11060) Alexa Fluor® 680

sc-53070 AF680
200 µg/ml
RMB2685.00

HSV-1 ICP0 抗体 (11060) Alexa Fluor® 790

sc-53070 AF790
200 µg/ml
RMB2685.00

Have the conjugated antibodies been used for flow cytometry?

Asked by: Pooja
Thank you for contacting Santa Cruz Biotechnology. For assistance please contact technical service by phone or email. Please call 800-457-3801or email [email protected]
Answered by: BlakeJ
Date published: 2025-02-21

Is it possible to use the HRP conjugated form sc-53070 HRP in both Western Blot and IP?

Asked by: jenniferc
Thank you for your inquiry. We do not recommend the use of the HRP conjugated form in IP. The unconjugated form of the antibody is the best choice when working in multiple applications that do not use the same conjugation (Agarose, Biotin, HRP, FITC, etc.).
Answered by: Technical Support 15
Date published: 2017-01-19
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Rated 4 out of 5 by from OK could be betterUsed in HeLa and HEK293T cells infected with WT HSV-1. It worked very well for immunostain detection, the WB was very poor and required a lot of cell extract to get a faint detection.
Date published: 2021-06-22
Rated 5 out of 5 by from Excellent!This antibody works great in Western blot analysis of HSV-1 ICP0 expression in HSV-1 (MacIntyre strain) infected African Green monkey kidney, HSV-1 (17 syn + strain) infected baby hamster kidney and mock infected control baby hamster kidney tissue extracts.
Date published: 2017-01-11
Rated 5 out of 5 by from Nice Western blot of HSVNice Western blot of HSV-1 ICP0 expression in HSV-1 (MacIntyre strain) infected African Green monkey kidney, HSV-1 (17 syn + strain) infected baby hamster kidney and mock infected control baby hamster kidney tissue extracts. -SCBT QC
Date published: 2015-02-11
Rated 5 out of 5 by from Antibody was published for use in IF andAntibody was published for use in IF and WB on human HEL cells - SCBT Publication Review
Date published: 2014-08-31
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HSV-1 ICP0 抗体 (11060) is rated 4.8 out of 5 by 5.
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