Date published: 2026-10-24

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HSF1 Antibody (C-5) - Western Blotting - Image 354574
HSF1 抗体 (C-5): sc-17756. HeLa (A), K-562 (B), MDA-MB-231 (C), A2058 (D) 和 MCF7 (E) 全细胞裂解液中 HSF1 表达的 Western 印迹分析.
HSF1 抗体 (C-5): sc-17756. HeLa (A), K-562 (B), MDA-MB-231 (C), A2058 (D) 和 MCF7 (E) 全细胞裂解液中 HSF1 表达的 Western 印迹分析.

HSF1 抗体 (C-5): sc-17756

5.0(7)
寫評論提問
说明书
  • HSF1抗体(C-5)是小鼠单克隆IgG2b κ, 在11篇文献中引用，规格为200 µg/ml
  • 免疫human物种的heat shock transcription factor 1 (HSF1)的氨基酸219-529
  • 推荐用于 mouse, rat 和 human 来源的HSF1 WB, IP, IF, IHC(P) 和 ELISA检测
  • 可用于凝胶迁移和ChIP的TransCruz试剂(sc-17756 X, 200 µg/0.1 ml)
  • 看 HSF1 (E-4): sc-17757，可查看有标记的 HSF1 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 2b BP-HRP">m-IgG2b BP-HRP是HSF1 Antibody (C-5) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。该试剂现与HSF1 Antibody (C-5) 打包提供（请参阅下面的订购信息）。
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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

额外HSF抗体，包括HSF1, HSF2, HSF4和HSF2BP

原核细胞和真核细胞通过诱导一组统称为热休克基因的基因来应对热应激和化学应激。在真核生物中，这种基因表达主要在转录水平上受到调控。热休克转录因子1和2（HSF1和HSF2），也称为HSTF1和HSTF2，参与了这种调控。HSF1和HSF2在mRNA和蛋白质水平上均被雌激素上调。HSF1通常以单体形式存在，其转录活性受到组成型磷酸化的抑制。激活后，HSF1形成三聚体，获得DNA结合活性并转移到细胞核。HSF2的活性与分化和发育有关，与HSF1一样，以三聚体形式结合DNA。已知HSF1和HSF2均受泛素途径的蛋白酶体抑制剂诱导。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

HSF1 抗体 (C-5) 参考文献:

  1. HSF1蛋白稳定性的调节：最新综述。  |  Huang, C., et al. 2018. Eur J Pharmacol. 822: 69-77. PMID: 29341886
  2. Hsf1与热休克反应的调节。  |  Pincus, D. 2020. Adv Exp Med Biol. 1243: 41-50. PMID: 32297210
  3. HSF1激活可限制HIV复制。  |  Nekongo, EE., et al. 2020. ACS Infect Dis. 6: 1659-1666. PMID: 32502335
  4. HSF1在细胞死亡中的多方面作用：最新综述。  |  Zhang, B., et al. 2021. Biochim Biophys Acta Rev Cancer. 1876: 188591. PMID: 34273469
  5. 癌症中的热休克蛋白和HSF1。  |  Cyran, AM. and Zhitkovich, A. 2022. Front Oncol. 12: 860320. PMID: 35311075
  6. HSF1激活的非编码应激反应：卫星lncRNA及其他，一个复杂场景中的新兴故事。  |  Vourc'h, C., et al. 2022. Genes (Basel). 13: PMID: 35456403
  7. HSF1 是急性髓性白血病中白血病干细胞自我更新的驱动因素。  |  Dong, Q., et al. 2022. Nat Commun. 13: 6107. PMID: 36245043
  8. HSF1通过抑制败血症模型中NLRP3诱导的脓毒症减轻脑损伤  |  He, YF., et al. 2023. Mediators Inflamm. 2023: 2252255. PMID: 36741074
  9. Mint3耗竭引起的能量应激通过HSF1失活使三阴性乳腺癌对化疗敏感。  |  Tanaka, N., et al. 2023. Cell Death Dis. 14: 815. PMID: 38081808
  10. BAP1调节胰腺癌中HSF1的活性和癌症免疫。  |  Yuan, W., et al. 2024. J Exp Clin Cancer Res. 43: 275. PMID: 39350280

订购信息

产品名称产品编号规格价格数量收藏夹

HSF1 抗体 (C-5)

sc-17756
200 µg/ml
CNY2422.00

HSF1 (C-5): m-IgG2b BP-HRP 套装

sc-551923
200 µg Ab; 10 µg BP
CNY2715.00

HSF1 抗体 (C-5) X

sc-17756 X
200 µg/0.1 ml
CNY2422.00

When should the TransCruz reagent sc-17756 X be used instead of the standard form sc-17756?

Asked by: jerojero
Thank you for your question. We recommend using the TransCruz reagent form when performing ChIP or GelShift assays. This form can also be used in other applications such as Western Blot or IHC, but the dilution should be adjusted by a factor of 10 to account for the higher original concentration.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by MAO123 from very good in WBUse: western blotting Dilution: 1:1000 cells: CFBE (human bronchial cells) Clear signal at the expected molecular weight
Date published: 2026-02-26
Rated 5 out of 5 by SM from Published for WB and IF in mouse NSC34 cell linesPublished for WB and IF in mouse NSC34 cell lines. -SCBT Publication Review
Date published: 2015-05-04
Rated 5 out of 5 by SS from Robust signal in WB in HeLa whole cell lysateRobust signal in WB in HeLa whole cell lysate. -SCBT QC
Date published: 2015-04-16
Rated 5 out of 5 by JM from Good publishable data in WB in human astrocytomaGood publishable data in WB in human astrocytoma cells, U-251 MG. -SCBT Publication Review
Date published: 2015-03-11
Rated 5 out of 5 by SM from Good specificity in WB in mouse transfectedGood specificity in WB in mouse transfected 293T and HeLa whole cell lysates. -SCBT QC
Date published: 2015-03-09
Rated 5 out of 5 by CJ from Strong band in WB in human HeLa cervicalStrong band in WB in human HeLa cervical carcinoma cells. -SCBT Publication Review
Date published: 2015-02-15
Rated 5 out of 5 by LF from Great immunoperoxidase nuclear and cytoplasmicGreat immunoperoxidase nuclear and cytoplasmic staining in formalin fixed, paraffin-embedded human urinary bladder tissue. -SCBT QC
Date published: 2015-02-07
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HSF1 抗体 (C-5) is rated 5.0 out of 5 by 7.
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