Date published: 2025-9-6

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hnRNP Q 抗体 (I8E4): sc-56703

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说明书
  • hnRNP Q 抗体 I8E4 是小鼠单克隆 IgG1 κ,hnRNP Q抗体, 在14篇文献中引用,规格为200 µg/ml
  • 针对human来源的重组hnRNP-Q
  • hnRNP Q 抗体 (I8E4) 推荐用于WB, IP 和 IF ,检测 mouse, rat, human 和 Xenopus来源的hnRNP Q
  • 抗hnRNP Q抗体(I8E4)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取hnRNP Q (I8E4): sc-56703免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP是hnRNP Q Antibody (I8E4) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与hnRNP Q Antibody (I8E4) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGκ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。

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関連項目

hnRNP Q 抗体(I8E4)是一种小鼠单克隆 IgG1 kappa 轻链抗体,可通过免疫印迹(WB)、免疫沉淀(IP)和免疫荧光(IF)检测小鼠、大鼠和人源 hnRNP Q 蛋白。抗 hnRNP Q 抗体 (I8E4) 有非共轭型和多种共轭型,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 共轭物。hnRNP Q 与几种关键蛋白相互作用,包括对运动神经元健康至关重要的存活运动神经元蛋白(SMN)。基因突变导致的 hnRNP Q 与 SMN 相互作用的中断会导致脊髓性肌肉萎缩,这是一种严重的神经退行性疾病。此外,hnRNP Q 表现出一种独特的表达模式,即在午夜后上调,这与负责合成褪黑激素的酶 AANAT 的衰退有关。hnRNP Q 对 AANAT mRNA 降解的这种节律性调控表明,它在昼夜节律调节中起着重要作用,进一步强调了 hnRNP Q 在 RNA 处理和生物节律维持方面的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

hnRNP Q 抗体 (I8E4) 参考文献:

  1. 小鼠单克隆抗心磷脂抗体结合蛋白的二维电泳和质谱鉴定:表征单一自身抗体交叉反应的强大技术。  |  Thebault, S., et al. 2000. Electrophoresis. 21: 2531-9. PMID: 10939468
  2. SMN 与新型 hnRNP 和剪接体蛋白家族相互作用。  |  Mourelatos, Z., et al. 2001. EMBO J. 20: 5443-52. PMID: 11574476
  3. 脊髓性肌萎缩症决定基因产物 Smn 与 hnRNP-R 和 gry-rbp/hnRNP-Q 的特异性相互作用:Smn 在运动轴突的 RNA 处理中的作用?  |  Rossoll, W., et al. 2002. Hum Mol Genet. 11: 93-105. PMID: 11773003
  4. 核蛋白质组中过度磷酸化的 C 端重复域相关蛋白将转录与 DNA/染色质修饰和 RNA 处理联系起来。  |  Carty, SM. and Greenleaf, AL. 2002. Mol Cell Proteomics. 1: 598-610. PMID: 12376575
  5. 有证据表明,SMA 不和谐家族中存在一种调节途径:SMN 水平降低会减少其相互作用伙伴和 Htra2-beta1 的数量。  |  Helmken, C., et al. 2003. Hum Genet. 114: 11-21. PMID: 14520560
  6. 通过二维凝胶电泳和质谱分析鉴定人内皮细胞中的转化生长因子-β1调节蛋白。  |  Lomnytska, M., et al. 2004. Proteomics. 4: 995-1006. PMID: 15048981
  7. HRP-2是一种异质核核糖核蛋白,对于秀丽隐杆线虫的胚胎发生和卵子发生至关重要。  |  Kinnaird, JH., et al. 2004. Exp Cell Res. 298: 418-30. PMID: 15265690
  8. 节律性血清素 N-乙酰转移酶 mRNA 降解对维持其昼夜节律摆动至关重要。  |  Kim, TD., et al. 2005. Mol Cell Biol. 25: 3232-46. PMID: 15798208
  9. 半乳糖凝集素-3稳定异质核糖核蛋白Q,从而维持人类结肠癌细胞的增殖。  |  Yoo, BC., et al. 2009. Cell Mol Life Sci. 66: 350-64. PMID: 19137262
  10. 异质核糖核蛋白 Q 是含 SH2 结构域的磷酸酶-2 的新型底物。  |  Watanabe, N., et al. 2013. J Biochem. 154: 475-80. PMID: 23946508
  11. 眼咽肌营养不良突变将RNA结合蛋白HNRNPQ与自噬体生物发生联系起来。  |  Ishtayeh, H., et al. 2023. Aging Cell. 22: e13949. PMID: 37559347
  12. hnRNP H 是剪接增强子复合物的一个组成部分,它能激活神经细胞中的 c-src 替代外显子。  |  Chou, MY., et al. 1999. Mol Cell Biol. 19: 69-77. PMID: 9858532

订购信息

产品名称产品编号规格价格数量收藏夹

hnRNP Q 抗体 (I8E4)

sc-56703
200 µg/ml
RMB2377.00

hnRNP Q (I8E4): m-IgGκ BP-HRP 套装

sc-521042
200 µg Ab, 40 µg BP
RMB2662.00

hnRNP Q 抗体 (I8E4) AC

sc-56703 AC
500 µg/ml, 25% agarose
RMB3129.00

hnRNP Q 抗体 (I8E4) HRP

sc-56703 HRP
200 µg/ml
RMB2377.00

hnRNP Q 抗体 (I8E4) FITC

sc-56703 FITC
200 µg/ml
RMB2482.00

hnRNP Q 抗体 (I8E4) PE

sc-56703 PE
200 µg/ml
RMB2580.00

hnRNP Q 抗体 (I8E4) Alexa Fluor® 488

sc-56703 AF488
200 µg/ml
RMB2685.00

hnRNP Q 抗体 (I8E4) Alexa Fluor® 546

sc-56703 AF546
200 µg/ml
RMB2685.00

hnRNP Q 抗体 (I8E4) Alexa Fluor® 594

sc-56703 AF594
200 µg/ml
RMB2685.00

hnRNP Q 抗体 (I8E4) Alexa Fluor® 647

sc-56703 AF647
200 µg/ml
RMB2685.00

hnRNP Q 抗体 (I8E4) Alexa Fluor® 680

sc-56703 AF680
200 µg/ml
RMB2685.00

hnRNP Q 抗体 (I8E4) Alexa Fluor® 790

sc-56703 AF790
200 µg/ml
RMB2685.00

Are there any issues with using sc-56703: hnRNP Q (I8E4) mouse monoclonal primary antibody on mouse samples?

Asked by: Professor Griffin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-56703 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 4 out of 5 by from Good antibody for immunoprecipitationThis hnRNPQ antibody (I8E4, sc-56703) works well for immunoprecipitation from human cells.
Date published: 2022-06-07
Rated 5 out of 5 by from Working very wellThis antibody is working very well. I can get strong bands for Western blotting.
Date published: 2020-02-15
Rated 5 out of 5 by from work wellThe antibody works really well for WB of cell lysates from THP1
Date published: 2017-11-14
Rated 5 out of 5 by from Great for WB and IFThe antibody works really well for WB of cell lysates from human origin, as well as for immunofluorescence analysis.
Date published: 2017-02-09
Rated 5 out of 5 by from Specific and robust in WBThis is an extremely strong and sensitive antibody, it detects hnRNP Q with a very high affinity! Smart choice if you are looking for a great reagent to detect hnRNP Q!
Date published: 2017-02-01
Rated 5 out of 5 by from Works well with HuhWorks well with Huh-7 cells in Western Blot -SCBT Publication Review
Date published: 2015-02-16
Rated 5 out of 5 by from Great Western Blot detection in A549 andGreat Western Blot detection in A549 and WI 38 whole cell lysates -SCBT QC
Date published: 2013-12-15
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hnRNP Q 抗体 (I8E4) is rated 4.9 out of 5 by 7.
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