Date published: 2025-9-6

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Histone Lysine Methyltransferase Inhibitor 抑制剂 (CAS 935693-62-2 free base)

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备用名:
BIX-01294
应用:
Histone Lysine Methyltransferase Inhibitor 是一种 HMT 酶抑制剂,名为 BIX-01294 三盐酸盐
CAS号码:
935693-62-2 free base
纯度:
>97%
分子量:
600
分子式:
C28H38N6O23HCl
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

快捷链接

组蛋白赖氨酸甲基转移酶抑制剂(BIX-01294)是一种G9a(组蛋白赖氨酸甲基转移酶(HMTase))抑制剂,特别显示可抑制G9a介导的H3K9me2(组蛋白H3赖氨酸9二甲基化)的产生,不与S-腺苷-甲硫氨酸辅因子竞争。去除组蛋白赖氨酸甲基转移酶抑制剂后,H3K9me2水平得以恢复。该分子可瞬时调节HMTase行为,为研究对基因表达和染色质组织的影响提供了工具。组蛋白赖氨酸甲基转移酶抑制剂是EHMT的抑制剂。


Histone Lysine Methyltransferase Inhibitor 抑制剂 (CAS 935693-62-2 free base) 参考文献

  1. 一种小分子 G9a 组蛋白甲基转移酶抑制剂可逆转 H3K9me2。  |  Kubicek, S., et al. 2007. Mol Cell. 25: 473-81. PMID: 17289593
  2. 用化学和遗传相结合的方法生成诱导多能干细胞。  |  Shi, Y., et al. 2008. Cell Stem Cell. 2: 525-8. PMID: 18522845
  3. 小分子化合物大大改善了多能干细胞的诱导。  |  Huangfu, D., et al. 2008. Nat Biotechnol. 26: 795-7. PMID: 18568017
  4. BIX-01294诱导的细胞自噬调节原纤毛的伸长。  |  Shin, JH., et al. 2015. Biochem Biophys Res Commun. 460: 428-33. PMID: 25796328
  5. BIX-01294 通过改善体细胞核的表观遗传重编程,提高了猪的克隆效率。  |  Huang, J., et al. 2016. Reproduction. 151: 39-49. PMID: 26604326
  6. BIX-01294通过诱导GSDME介导的热解作用增强胃癌的化疗效果。  |  Deng, BB., et al. 2020. Cell Biol Int. 44: 1890-1899. PMID: 32437063
  7. BIX-01294对鼻咽癌化疗敏感性的增强取决于自噬诱导的热解。  |  Li, Q., et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52: 1131-1139. PMID: 33085742
  8. BIX-01294 是一种 G9a 抑制剂,它通过抑制鼻咽癌细胞的自噬通量来抑制细胞增殖。  |  Li, Q., et al. 2021. Invest New Drugs. 39: 686-696. PMID: 33387131
  9. EHMT2 抑制剂 BIX-01294 可诱导弥漫大 B 细胞淋巴瘤细胞发生由内质网应激介导的凋亡和自噬。  |  Xu, L., et al. 2021. J Cancer. 12: 1011-1022. PMID: 33442400
  10. BIX-01294 通过抑制干性基因的表达,增强了化疗对结直肠癌的效果。  |  Liu, S., et al. 2022. Biochem Biophys Res Commun. 590: 169-176. PMID: 34979318

订购信息

产品名称产品编号规格价格数量收藏夹

Histone Lysine Methyltransferase Inhibitor, 5 mg

sc-202651
5 mg
RMB1670.00

How is this manufactured – synthetically or has an animal/human been used to obtain the chemical? We need to know to get the correct customs form for importation to Australia.

Asked by: AnitaP
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact your local distributor or our Technical Service Department to inquire about the source information for the biochemical.
Answered by: Tech Service
Date published: 2019-02-11
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Rated 5 out of 5 by from Shi et alShi et al. (PubMed ID 18522845) used Histone Lysine Methyltransferase Inhibitor (BIX-01294) to inhibit G9a histone methyltrasferase and found this to improve reprograming efficiency in neural progenitor cells transduced with Oct3/4-Klf4. -SCBT Publication Review
Date published: 2015-04-27
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Histone Lysine Methyltransferase Inhibitor 抑制剂 is rated 5.0 out of 5 by 1.
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