Date published: 2025-9-6

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Histone H2A.X 抗体 (938CT5.1.1): sc-517336

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  • Histone H2A.X 抗体 938CT5.1.1 是小鼠单克隆 IgG1 κ,Histone H2A.X抗体, 在43篇文献中引用,规格为100 µg/ml
  • 针对与human来源的Histone H2A.X C端区域氨基酸115-143对应的合成肽
  • Histone H2A.X 抗体(938CT5.1.1)推荐用于通过 WB, IP, IF 和 IHC(P) 检测 Histone H2A.X 的 human 来源
  • 关于如何获取Histone H2A.X (938CT5.1.1): sc-517336免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 Histone H2A.X 抗体 (938CT5.1.1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Histone H2A.X 抗体 (938CT5.1.1) 组合成套装提供。 (请参阅下面的订购信息)。

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组蛋白H2A.X抗体(938CT5.1.1)是一种小鼠单克隆IgG1 kappa轻链抗体,专门针对组蛋白H2A.X,也称为X变异组蛋白H2A或H2AX。组蛋白H2A.X是组蛋白H2A家族的一员,参与染色质的核小体组织,与其他H2A变体不同,它具有高度保守的C端基序。组蛋白H2A.X在DNA损伤反应中起着至关重要的作用。在电离辐射或DNA双链断裂时,H2A.X会迅速磷酸化形成γ-H2A.X,从而促进受损DNA的识别和修复。γ-H2A.X会启动Rad50、Rad51和BRCA1等修复因子的募集,并在免疫球蛋白基因的类转换重组过程中形成核聚变。抗组蛋白H2A.X抗体(938CT5.1.1)针对人类组蛋白H2A.X C末端区域115-143位氨基酸的合成肽进行免疫,在蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和石蜡包埋切片免疫组织化学(IHCP)应用中可与人类来源的H2A.X发生反应。这种未结合的组蛋白H2A.X(938CT5.1.1)抗体可在各种研究环境中广泛使用,特别是研究染色质组织和DNA修复机制的研究。通过靶向基因组稳定性的关键参与者,组蛋白H2A.X单克隆抗体(938CT5.1.1)成为研究细胞对DNA损伤和基因组维持过程的反应的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Histone H2A.X 参考文献:

  1. 细胞凋亡过程中 DNA 断裂的引发剂会诱导 H2AX 组蛋白在丝氨酸 139 处发生磷酸化。  |  Rogakou, EP., et al. 2000. J Biol Chem. 275: 9390-5. PMID: 10734083
  2. 组蛋白 H2AX 在 DNA 损伤后将修复因子招募到核病灶中起着至关重要的作用。  |  Paull, TT., et al. Curr Biol. 10: 886-95. PMID: 10959836
  3. 组蛋白 H2AX 在复制压力下以 ATR 依赖性方式磷酸化。  |  Ward, IM. and Chen, J. 2001. J Biol Chem. 276: 47759-62. PMID: 11673449
  4. AID 是引发 Nbs1/gamma-H2AX 病灶形成和类切换位点突变的必要条件。  |  Petersen, S., et al. 2001. Nature. 414: 660-665. PMID: 11740565
  5. 组蛋白变异体H2A.X是上皮-间质转化的调节因子。  |  Weyemi, U., et al. 2016. Nat Commun. 7: 10711. PMID: 26876487
  6. 外周血单核细胞中组蛋白H2A.X的磷酸化可能是监测非糖尿病个体心脏代谢风险的有用指标。  |  Yoon, SR., et al. 2017. Dis Markers. 2017: 2050194. PMID: 28572698
  7. 组蛋白伴侣FACT协调H2A.X依赖性信号传导和DNA损伤修复。  |  Piquet, S., et al. 2018. Mol Cell. 72: 888-901.e7. PMID: 30344095
  8. 组蛋白变异体H2A.X的磷酸化状态控制着人类干细胞和祖细胞的命运决定。  |  Orlando, L., et al. 2021. Cell Rep. 34: 108818. PMID: 33691101
  9. 晚期红细胞生成中组蛋白H2A.X的磷酸化与Caspase启动的染色质凝结。  |  Jeffery, NN., et al. 2021. Epigenetics Chromatin. 14: 37. PMID: 34330317
  10. 组蛋白H2A变体的聚焦:从B到X再到Z。  |  Herchenröther, A., et al. 2023. Semin Cell Dev Biol. 135: 3-12. PMID: 35365397
  11. 小鼠 H2A.X 基因的结构及与 9 号染色体上 UPS 基因座的物理联系:通过序列分析将人类 H2A.X 基因分配到 11q23 上。  |  Porcher, C. and Grandchamp, B. 1995. Genomics. 25: 312-3. PMID: 7774939
  12. 人类组蛋白 H2A.X 基因的特征。其启动子与其他 H2A 基因启动子的比较。  |  Ivanova, VS., et al. 1994. J Biol Chem. 269: 24189-94. PMID: 7929075

订购信息

产品名称产品编号规格价格数量收藏夹

Histone H2A.X 抗体 (938CT5.1.1)

sc-517336
100 µg/ml
RMB2377.00

Histone H2A.X (938CT5.1.1): m-IgG Fc BP-HRP 套装

sc-541102
100 µg Ab; 10 µg BP
RMB2662.00

Histone H2A.X (938CT5.1.1): m-IgG1 BP-HRP 套装

sc-542581
100 µg Ab; 20 µg BP
RMB2662.00

Has this antibody been tested in mouse cells?

Asked by: jefffrancis
Thank you for your question. This antibody has not yet been tested in mouse and so that is not a recommended species at this time. We are still gathering data to show on our website. Check back for updates!
Answered by: Tech Service
Date published: 2019-12-12
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Rated 5 out of 5 by from Ottimo funzionamentoL'anticorpo da un buon segnale pulito in WB dei lisati totali di cellule di neuroblastoma
Date published: 2025-01-08
Rated 5 out of 5 by from Good for Western BlotAntibody works well in human cell lines HEK293, CCRF-CEM, HepG2, and Raji. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from IHC is very goodWe used this antibody for IHC on Gastric Cancer tissues ,the result is very good !
Date published: 2021-11-12
Rated 5 out of 5 by from Good in western blottingovernight incubation at 4°C 1:100 dilution. Good signal
Date published: 2020-11-06
Rated 5 out of 5 by from Good antibodyUsed for immunofluorescence and it worked very well!
Date published: 2019-10-26
Rated 5 out of 5 by from Great AntibodyThanks to Santa Cruz for giving the trial sample. The antibody worked great with clean band in SH-SY5Y cells
Date published: 2018-06-20
Rated 5 out of 5 by from Good antibody!works for WB with 1:1000 and band is very clear. Good
Date published: 2018-04-06
Rated 5 out of 5 by from Good antibodyDecent band detected in HepG2 cells, at just a little above 15kD protein marker
Date published: 2018-03-30
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Histone H2A.X 抗体 (938CT5.1.1) is rated 4.9 out of 5 by 12.
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