GSK-J4 的分子结构, CAS编号: 1373423-53-0
GSK-J4 (CAS 1373423-53-0)
备用名:
ethyl 3-((2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoate
CAS号码:
1373423-53-0
分子量:
417.513
分子式:
C24H27N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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GSK-J4 (CAS 1373423-53-0) 参考文献
- GSK-J4介导的胚状体分化过程中的转录组变化 | Mandal, C., et al. 2017. Mol Cells. 40: 737-751. PMID: 29047260
- GSK-J4 与多柔比星在 KRAS 突变性甲状腺癌中的协同作用 | Lin, B., et al. 2020. Front Pharmacol. 11: 632. PMID: 32477122
- GSK-J4通过ER应激诱导细胞周期停滞和凋亡，以及GSK-J4和地西他滨在急性髓性白血病KG-1a细胞中的协同作用。 | Chu, X., et al. 2020. Cancer Cell Int. 20: 209. PMID: 32514253
- GSK-J4 对小鼠前列腺癌异种移植物中 JMJD3 组蛋白去甲基化酶的影响 | Sanchez, A., et al. 2022. Cancer Genomics Proteomics. 19: 339-349. PMID: 35430567
- 特异性组蛋白赖氨酸去甲基化酶 6A 抑制剂 GSK-J4 通过保护 H3K27 甲基化和减少铁变态反应改善心肌细胞的脂肪毒性 | Xu, K., et al. 2022. Front Cardiovasc Med. 9: 907747. PMID: 35722096
- 组蛋白去甲基化酶抑制剂 GSK-J4 是通过 DKK1 调节糖尿病肾病肾脏纤维化的治疗靶点 | Hung, PH., et al. 2022. Int J Mol Sci. 23: PMID: 36012674
- CCL17mAb/GSK-J4阻断CCL17可改善大鼠术后疼痛模型中的痛觉过敏。 | Zhang, Z., et al. 2023. Biol Pharm Bull. 46: 533-541. PMID: 36792181
- GSK-J4:一种H3K27组蛋白去甲基化酶抑制剂,可作为潜在的抗癌药物。 | Dalpatraj, N., et al. 2023. Int J Cancer. 153: 1130-1138. PMID: 37165737
- 多纳非尼和GSK-J4通过上调HMOX1表达协同诱导肝癌铁死亡。 | Zheng, C., et al. 2023. Adv Sci (Weinh). 10: e2206798. PMID: 37330650
- GSK-J4抑制KDM6B组蛋白去甲基化酶通过调节NF-κB信号传导阻断套细胞淋巴瘤细胞与基质细胞的粘附。 | Sadeghi, L. and Wright, APH. 2023. Cells. 12: PMID: 37566089
抑制剂：
2400001E08Rik, ALKBH3, ALKBH4, ALKBH5, ALKBH6, ANKRD24, ANKS4B, BC066135, BC068157, BC094916, BC100530, BC106175, BCORL1, CHD (chromodomain helicase), CHD7, COL20A1, D5Ertd577e, DBC1, E130012A19Rik, E430029J22Rik, EG408191, EG432502, EG434797, FBXW18, HEB, Histone cluster 1 H2AA, Histone cluster 1 H2AE, Histone cluster 1 H2AH, Histone cluster 1 H2AI, Histone cluster 1 H2AJ, Histone cluster 1 H2AK, Histone cluster 1 H2AL, Histone cluster 1 H2AM, Histone cluster 1 H2BA, Histone cluster 1 H2BB, Histone cluster 1 H2BC, Histone cluster 1 H2BE, Histone cluster 1 H2BF, Histone cluster 1 H2BG, Histone cluster 1 H2BH, Histone cluster 1 H2BI, Histone cluster 1 H2BJ, Histone cluster 1 H2BL, Histone cluster 1 H2BM, Histone cluster 1 H2BO, Histone cluster 1 H3A, Histone cluster 1 H3C, Histone cluster 1 H3F, JMJD1A, JMJD1B, JMJD2B, JMJD2C, JMJD2D, KDM (lysine demethylase), KRTAP13-3, KTELC1, Mel-18, Mi2-β, MSL-1, NO66, Olfr64, OTTMUSG00000016785, OTTMUSG00000016788, PCDHGA10, PLU-1, PRDM16, SETD6, Six1, TADA2L, Tomm20l, TRIM27, UNQ6126, UTY, XAGE-1C, 和 ZSCAN4B.激活剂：
AF-10, ARID2, CARM1, D5Ertd577e, DXBay18, E130311K13Rik, E230019M04Rik, EG278167, ELL, FGF-19, SLUG, 和 SUV420H1.订购信息
| 产品名称 | 产品编号 | 规格 | 价格 | 数量 | 收藏夹 | |
GSK-J4, 100 mg | sc-507551 | 100 mg | RMB14385.00 |