Date published: 2025-9-9

021-6093-6350

SCBT Portrait Logo
Seach Input

group VI iPLA2 抗体 (A-10): sc-137189

4.0(3)
寫評論提問

说明书
  • group VI iPLA2 抗体(A-10)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 免疫human物种的group VI iPLA2的氨基酸1-120
  • 推荐用于 mouse, rat 和 human 来源的calcium-independent PLA2 WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是group VI iPLA2 Antibody (A-10) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与group VI iPLA2 Antibody (A-10) 打包提供(请参阅下面的订购信息)。

    快捷链接

    関連項目

    磷脂酶催化磷脂释放脂肪酸。磷脂酶家族中的一员iPLA2被检测为膜结合蛋白,具有多种较小的亚型,这是由选择性剪接引起的。两种亚型,Ankyrin-iPLA2-1和-2,缺乏催化结构域,被认为参与iPLA2活性的负调控。 SH-iPLA2亚型在细胞质中定位。编码iPLA2的人类基因位于染色体22q13.1。另一种磷脂酶sPLA2属于分泌型磷脂酶A2家族,代表了一个不断扩大的相关酶家族。sPLA2具有膜结合和分泌形式,由单个基因编码。sPLA2参与生物膜中磷脂代谢的调节和类花生酸生物合成。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    group VI iPLA2 抗体 (A-10) 参考文献:

    1. 人类胰岛表达两种不同催化活性的 VI 族磷脂酶 A2 (iPLA2) mRNA,它们是由染色体 22q13.1 上 iPLA2 基因转录本的外显子剪接机制产生的。  |  Ma, Z., et al. 1999. J Biol Chem. 274: 9607-16. PMID: 10092647
    2. 内质网应激诱导的胰岛素分泌细胞凋亡可通过过表达VIA组钙非依赖性磷脂酶A2(iPLA2 beta)而放大,并通过抑制iPLA2 beta而抑制。  |  Ramanadham, S., et al. 2004. Biochemistry. 43: 918-30. PMID: 14744135
    3. 过氧化氢依赖性过氧化还原酶6(Prdx6)的过度氧化通过上调iPLA2活性在细胞毒性中发挥作用。  |  Kim, SY., et al. 2008. J Biol Chem. 283: 33563-8. PMID: 18826942
    4. iPLA2、TRPM8和TRPA1在化学诱导的寒冷过敏中的作用。  |  Gentry, C., et al. 2010. Mol Pain. 6: 4. PMID: 20092626
    5. PRDX6通过其GPx和iPLA2活性促进肺癌进展。  |  Yun, HM., et al. 2014. Free Radic Biol Med. 69: 367-76. PMID: 24512906
    6. 前体素2的缺失与iPLA2活性增强和肺部肿瘤的形成有关。  |  Yun, HM., et al. 2014. Oncogene. 33: 5193-200. PMID: 24858037
    7. 2型糖尿病和慢性牙周炎中人类中性粒细胞的IPLA2 mRNA表达。  |  Ayilavarapu, S., et al. 2014. J Int Acad Periodontol. 16: 121-6. PMID: 25654966
    8. 小鼠模型中携带VIA iPLA2基因缺陷的人类婴儿神经轴索营养不良(INAD)的线粒体干扰了Ca(2+)的调节,降低了Ca(2+)的容量。  |  Strokin, M. and Reiser, G. 2016. Neurochem Int. 99: 187-193. PMID: 27395788
    9. 对精神分裂症中钙非依赖性磷脂酶A2(iPLA2)和细胞质磷脂酶A2(cPLA2)的研究。  |  Xu, C., et al. 2019. Psychiatry Res. 273: 782-787. PMID: 31207866
    10. 帕金森病相关的iPLA2-VIA/PLA2G6通过膜重塑调节神经元功能和α-突触核蛋白的稳定性。  |  Mori, A., et al. 2019. Proc Natl Acad Sci U S A. 116: 20689-20699. PMID: 31548400

    订购信息

    产品名称产品编号规格价格数量收藏夹

    group VI iPLA2 抗体 (A-10)

    sc-137189
    200 µg/ml
    RMB2377.00

    group VI iPLA2 (A-10): m-IgG Fc BP-HRP 套装

    sc-537417
    200 µg Ab; 10 µg BP
    RMB2662.00

    group VI iPLA2 (A-10): m-IgGκ BP-HRP 套装

    sc-534674
    200 µg Ab; 40 µg BP
    RMB2662.00

    group VI iPLA2 (A-10): m-IgG1 BP-HRP 套装

    sc-545177
    200 µg Ab; 20 µg BP
    RMB2662.00

    Hi, I am interested in you group VI iPLA2 Antibody (A-10): sc-137189 antibody against iPLA2 and was wondering whether you provide a free sample to test on my cells. Thanks, Nada

    Asked by: Nada AlSaffar
    Thank you for your question. Please contact Technical Service for information on how to obtain a sample.
    Answered by: SCBT Heidelberg Support
    Date published: 2018-12-14

    I need to use an antibody to detect the protein in samples of avian origin. Do you know if sc-137189: group VI iPLA2 (A-10) mouse monoclonal antibody will work?

    Asked by: Germaine
    Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
    Answered by: Technical Support
    Date published: 2017-03-06
    • y_2025, m_9, d_7, h_4CST
    • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasquestionsanswers, tq_2
    • loc_zh_CN, sid_137189, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getContent, 104ms
    • QUESTIONS, PRODUCT
    Rated 4 out of 5 by from Bands seen in WB using Hs 181 Tes and NTERABands seen in WB using Hs 181 Tes and NTERA-2 cl.D1 whole cell lysates. -SCBT QC
    Date published: 2015-03-04
    Rated 4 out of 5 by from Strong band seen in WB using rat testis tissueStrong band seen in WB using rat testis tissue extract. -SCBT QC
    Date published: 2015-02-08
    Rated 4 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB. -SCBT QC
    Date published: 2014-10-22
    • y_2025, m_9, d_7, h_4
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_3
    • loc_zh_CN, sid_137189, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getReviews, 18ms
    • REVIEWS, PRODUCT
    group VI iPLA 2 抗体 (A-10) is rated 4.0 out of 5 by 3.
    • y_2025, m_9, d_7, h_4
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_3
    • loc_zh_CN, sid_137189, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getAggregateRating, 112ms
    • REVIEWS, PRODUCT