Date published: 2025-9-7

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granzyme B 抗体 (GB7): sc-56119

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说明书
  • granzyme B 抗体 GB7 是小鼠单克隆 IgG2a, 在2篇文献中引用,提供 100 µg/ml
  • 针对全长granzyme B,human起源
  • 推荐用于 human 来源的granzyme B WB, IP, IF 和 IHC(P)检测
  • 看 granzyme B (2C5): sc-8022,可查看有标记的 granzyme B 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前,我们还没有完成granzyme B 抗体 (GB7)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

颗粒酶B抗体(GB7)是一种IgG2a小鼠单克隆颗粒酶B抗体,可通过WB、IF和IHC(P)检测人源颗粒酶B。颗粒酶B抗体(GB7)可作为非偶联抗颗粒酶B抗体。Granzyme A和Granzyme B是丝氨酸蛋白酶,可以介导细胞毒性T淋巴细胞(CTL)和天然杀伤细胞(NK)中的凋亡信号传导。Granzyme A和Granzyme B都以不活性的前酶的形式合成,它们储存在细胞毒性颗粒中,并在效应细胞脱颗粒期间释放出来。在激活的CTLs中,Granzyme A和Granzyme B由猫科肽C加工和激活,然后通过两种不同的途径诱导凋亡。Granzyme B以蛋白酶的方式剪切和激活包括caspase-3、caspase-6、caspase-7和caspase-9在内的硫氨酸蛋白酶家族成员。被剪切后,这些caspases组装成活性全酶,然后通过涉及核层蛋白和PARP(多聚(ADP核糖)聚合酶)的定义蛋白酶级联介导凋亡。Granzyme A介导凋亡的激活,通过诱导单链DNA断裂、膜扰动和核凝聚,这是一种独立于caspase激活或caspase蛋白酶级联的替代途径。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

granzyme B 抗体 (GB7) 参考文献:

  1. 颗粒酶B诱导的细胞死亡。  |  Andrade, F., et al. 2004. Acta Haematol. 111: 28-41. PMID: 14646343
  2. 颗粒酶B作为参与心血管疾病的新因子。  |  Saito, Y., et al. 2011. J Cardiol. 57: 141-7. PMID: 21168312
  3. 颗粒酶B在皮肤炎症和疾病中的作用。  |  Turner, CT., et al. 2019. Matrix Biol. 75-76: 126-140. PMID: 29247692
  4. 颗粒酶B在炎症性皮肤病中的病理功能。  |  Hiroyasu, S., et al. 2021. J Dermatol Sci. 104: 76-82. PMID: 34772583
  5. Th17 极化细胞对人类少突胶质细胞的接触依赖性颗粒酶 B 介导的细胞毒性  |  Jamann, H., et al. 2022. Front Immunol. 13: 850616. PMID: 35479072
  6. 在HSV-2生殖器感染期间,NK细胞分泌的细胞外颗粒酶B可导致上皮溃疡。  |  Lim, YS., et al. 2023. Cell Rep. 42: 112410. PMID: 37071533
  7. 颗粒酶B在免疫反应中的成像和监测。  |  Li, X., et al. 2024. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 16: e1928. PMID: 37715320
  8. 颗粒酶B降解细胞外基质并促进炎症和脉络膜新生血管形成。  |  Obasanmi, G., et al. 2024. Angiogenesis. 27: 351-373. PMID: 38498232
  9. 颗粒酶B在衰老和与年龄相关的病理中的作用。  |  Richardson, KC., et al. 2024. Trends Mol Med. 30: 1165-1179. PMID: 39181801
  10. 颗粒酶B PET/CT成像可评估胃癌对免疫疗法的早期反应。  |  Liu, Q., et al. 2024. J Nucl Med. 65: 1695-1701. PMID: 39389628

订购信息

产品名称产品编号规格价格数量收藏夹

granzyme B 抗体 (GB7)

sc-56119
100 µg/ml
RMB2377.00

Is sc-56119 disposable or not?

Asked by: SPark
Thank you for your question. Please consult your local/regional laboratory safety guidelines for how to dispose of the antibody.
Answered by: Technical Support
Date published: 2019-01-25

Can sc-56119: granzyme B (GB7) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: jenniferc
Thank you for your question. Yes, sc-56119: granzyme B (GB7) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 4 out of 5 by from Performed well in WB in NKPerformed well in WB in NK-92 whole cell lysate. -SCBT QC
Date published: 2015-03-03
Rated 4 out of 5 by from Robust band of interest detected in WB inRobust band of interest detected in WB in human granzyme B transfected 293T whole cell lysate. -SCBT QC
Date published: 2014-06-14
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granzyme B 抗体 (GB7) is rated 4.0 out of 5 by 2.
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