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GPNMB 抗体 (G-8): sc-271416

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说明书
  • GPNMB抗体(G-8)是小鼠单克隆IgG2a (kappa轻链),规格为200 µg/ml
  • 免疫原氨基酸序列38-158位于human物种的GPNMB的N-terminus附近
  • 推荐用于 human 来源的GPNMB isoforms 1 and 2 WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP和 2a BP-HRP">m-IgG2a BP-HRP是GPNMB Antibody (G-8) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与GPNMB Antibody (G-8) 打包提供(请参阅下面的订购信息)。
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    跨膜糖蛋白NMB(GPNMB),也被称为造血生长因子诱导性神经激肽-1(HGFIN),是一种单次跨膜I型膜蛋白。GPNMB属于Pmel-17/NMB蛋白家族,作为一种黑色素生成酶。GPNMB的表达不仅限于黑色素细胞系细胞,在低转移性黑色素瘤细胞系中表达最高。而在高转移性黑色素瘤细胞系中无表达。GPNMB可能在淋巴造血干细胞的成熟过程中发挥重要作用。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    GPNMB 抗体 (G-8) 参考文献:

    1. Gpnmb/骨活素,癌症免疫治疗中极具吸引力的靶点。  |  Zhou, LT., et al. 2012. Neoplasma. 59: 1-5. PMID: 22017590
    2. Gpnmb/骨活素:肿瘤和非肿瘤病变的指标和治疗靶点。  |  Zhuo, H. and Zhou, L. 2016. Pharmazie. 71: 555-561. PMID: 29441921
    3. 糖蛋白 GPNMB 可通过 CD44 受体减轻星形胶质细胞的炎症反应。  |  Neal, ML., et al. 2018. J Neuroinflammation. 15: 73. PMID: 29519253
    4. GPNMB在炎症中的作用。  |  Saade, M., et al. 2021. Front Immunol. 12: 674739. PMID: 34054862
    5. GPNMB通过与α-突触核蛋白相互作用增加帕金森病的风险。  |  Diaz-Ortiz, ME., et al. 2022. Science. 377: eabk0637. PMID: 35981040
    6. GPNMB:一种有效的癌症免疫抑制剂。  |  Lazaratos, AM., et al. 2022. Oncogene. 41: 4573-4590. PMID: 36050467
    7. 整合的单细胞转录组分析显示,GPNMB高表达的巨噬细胞促进PN-MES转化,并阻碍GBM中的T细胞激活。  |  Xiong, A., et al. 2022. EBioMedicine. 83: 104239. PMID: 36054938
    8. 单核吞噬细胞的高分辨率分析揭示了GPNMB作为人类结肠肝转移的预后标志物。  |  Cortese, N., et al. 2023. Cancer Immunol Res. 11: 405-420. PMID: 36652202
    9. 糖蛋白非转移性蛋白B(GPNMB):溶酶体与肥胖之间的缺失环节。  |  Bianco, V. and Kratky, D. 2023. Exp Clin Endocrinol Diabetes. 131: 639-645. PMID: 37956971
    10. 神经退行性疾病中神经胶质细胞内溶酶体功能和炎症中的Progranulin和GPNMB相互作用。  |  Gillett, DA., et al. 2023. J Neuroinflammation. 20: 286. PMID: 38037070

    订购信息

    产品名称产品编号规格价格数量收藏夹

    GPNMB 抗体 (G-8)

    sc-271416
    200 µg/ml
    CNY2422.00

    GPNMB (G-8): m-IgG Fc BP-HRP 套装

    sc-540238
    200 µg Ab; 10 µg BP
    CNY2715.00

    GPNMB (G-8): m-IgG2a BP-HRP 套装

    sc-546874
    200 µg Ab; 10 µg BP
    CNY2715.00

    Does it detect mouse GPNMB with IHC-P in mouse tissue ?

    Asked by: lionelB
    Thank you for your question. Based on our test results we can only recommend GPNMB Antibody (G-8): sc-271416 for detection of GPNMB isoforms 1 and 2 of human origin by WB, IP, IF and ELISA.
    Answered by: Tech Support Europe
    Date published: 2025-11-06

    I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with GPNMB (G-8): sc-271416?

    Asked by: TinTin
    We recommend using one of our our exclusive Mouse IgG Binding Proteins conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 5 out of 5 by QZ from Produced nice Western blot data of GPNMBProduced nice Western blot data of GPNMB expression in SK-MEL-28 whole cell lysate. -SCBT QC
    Date published: 2013-04-07
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    GPNMB 抗体 (G-8) is rated 5.0 out of 5 by 1.
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