Date published: 2025-9-8

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GPD2 抗体 (D-12): sc-390830

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说明书
  • GPD2 抗体 D-12 是小鼠单克隆 IgM κ,GPD2抗体, 在4篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的GPD2的内部区域内的氨基酸463-492之间
  • 推荐用于 mouse, rat, human 和 来源的GPD2 WB, IP, IF, IHC(P) 和 ELISA检测; 也和以下物种反应,包括: 和 equine, canine, bovine, porcine and avian
  • 关于如何获取GPD2 (D-12): sc-390830免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP 是 GPD2 抗体 (D-12) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与GPD2 抗体 (D-12) 组合成套装提供。 (请参阅下面的订购信息)。其他m-IgGκ BP 偶联产品,请参阅我们的小鼠 IgG 结合蛋白完整列表。

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関連項目

GPD2抗体(D-12)是一种IgM κ小鼠单克隆GPD2抗体(也称为GPD2抗体),它通过WB、IP、IF、IHC(P)和ELISA技术检测小鼠、大鼠和人类来源的GPD2蛋白。GPD2抗体(D-12)可以作为非偶联的抗GPD2抗体。GPD2(甘油-3-磷酸脱氢酶2,线粒体),也称为GDH2或GPDM,是一种727个氨基酸的蛋白质,属于FAD依赖性甘油-3-磷酸脱氢酶家族。GPD2参与甘油-3-磷酸(G-3-P)转化为二羟丙酮磷酸(DHAP),同时减少酶结合的FAD。GPD2定位于线粒体内膜的外表面,与GPD1(一种细胞质NAD连接的GPD)结合形成甘油磷酸穿梭,最终导致糖酵解过程中形成的NADH再氧化。GPD2在成人和胎儿组织中广泛表达,在人胰岛中含量最高,对胰岛B细胞葡萄糖传感功能至关重要。GPD2水平降低导致非胰岛素依赖型糖尿病中葡萄糖刺激的胰岛素释放受损。GPD2以两种选择性剪接的同工酶形式存在,含有两个EF手结构域,并映射到人类染色体2q24.1。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

GPD2 抗体 (D-12) 参考文献:

  1. 人类线粒体甘油磷酸脱氢酶基因两个启动子的功能分析。  |  Gong, Q., et al. 2000. J Biol Chem. 275: 38012-21. PMID: 10954707
  2. 缺乏线粒体甘油磷酸脱氢酶的小鼠甲状腺产热正常,但生存能力和脂肪含量降低。  |  Brown, LJ., et al. 2002. J Biol Chem. 277: 32892-8. PMID: 12093799
  3. 同时缺乏线粒体和细胞质甘油磷酸脱氢酶的小鼠出现致命性低血糖酮症和甘油尿。  |  Brown, LJ., et al. 2002. J Biol Chem. 277: 32899-904. PMID: 12093800
  4. 非综合征性智力低下患者GPD2基因的半合子不足。  |  Daoud, H., et al. 2009. Hum Genet. 124: 649-58. PMID: 19011903
  5. 智力障碍和半合子GPD2突变。  |  Barge-Schaapveld, DQ., et al. 2013. Am J Med Genet A. 161A: 1044-50. PMID: 23554088
  6. 七叶素通过结合肿瘤PGK2、GPD2和GPI来抑制癌细胞的糖酵解。  |  Wu, ST., et al. 2020. Front Pharmacol. 11: 379. PMID: 32292350
  7. SPARC通过调节GPD2介导的线粒体呼吸来控制肝癌细胞的迁移和侵袭。  |  Liu, L., et al. 2024. Biochem Genet. 62: 4518-4535. PMID: 38334876
  8. 人类线粒体甘油磷酸脱氢酶(GPDm)同工酶。  |  Shaw, MA., et al. 1982. Ann Hum Genet. 46: 11-23. PMID: 6808887
  9. 线粒体甘油-3-磷酸脱氢酶。克隆替代剪接的人胰岛细胞 cDNA, 组织分布, 物理图谱和多态遗传标记的鉴定。  |  Ferrer, J., et al. 1996. Diabetes. 45: 262-6. PMID: 8549872
  10. 通过胰岛素治疗使 GK 大鼠胰岛线粒体甘油磷酸脱氢酶和丙酮酸羧化酶偏低的情况恢复正常。  |  MacDonald, MJ., et al. 1996. Diabetes. 45: 886-90. PMID: 8666138
  11. 人类线粒体甘油磷酸脱氢酶编码基因和假基因的结构组织和图谱。  |  Brown, LJ., et al. 1996. Gene. 172: 309-12. PMID: 8682323
  12. 一个糖尿病患者家族的线粒体甘油磷酸脱氢酶基因钙结合域发生突变。  |  Novials, A., et al. 1997. Biochem Biophys Res Commun. 231: 570-2. PMID: 9070847

订购信息

产品名称产品编号规格价格数量收藏夹

GPD2 抗体 (D-12)

sc-390830
200 µg/ml
RMB2377.00

GPD2 (D-12): m-IgGκ BP-HRP 套装

sc-551109
200 µg Ab; 40 µg BP
RMB2662.00

GPD2 (D-12) 中和勝肽

sc-390830 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-390830 P appropriate for?

Asked by: Randy McDonald
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from strong signalWe use dilution 1:500 got specific band,strong western blot with low background, .
Date published: 2017-05-28
Rated 5 out of 5 by from results is goodI used this antibody in western blot (dilution 1:500), second antibody is 1:5000. The results is good.
Date published: 2017-02-26
Rated 5 out of 5 by from satisfied with the resultWe are very satisfied with GPD2 is really good and I have used it on my recent research, very good WB, signal strong at 1:500 dilution.
Date published: 2017-02-08
Rated 5 out of 5 by from Superb immunoperoxidase cytoplasmic stainingSuperb immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human heart muscle tissue. -SCBT QC
Date published: 2015-05-21
Rated 5 out of 5 by from Good Western Blot data of GPD2 expressionGood Western Blot data of GPD2 expression in Hs 181 Tes whole cell lysate. -SCBT QC
Date published: 2014-05-17
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GPD2 抗体 (D-12) is rated 5.0 out of 5 by 5.
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